Role of polymorphism (rs1024611) in monocyte chemoattractant protein-1 gene in diabetic foot ulcer of Iraqi patients

Obied, Mariam Riyadh; Al-Tu’ma, Fadhil Jawad; Al-Jameel, Hameed Hussein

doi:10.1016/j.genrep.2019.100502

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Different results were shown in the study of Hamed et al in 2019. In Hamed's study, there was no significant difference in the number of blast cells in the TET2 gene polymorphism [9]. In the last two decades, advances in gene sequencing have been able to document gene sequence variations between individuals, implying that phenotypic diversity is formed by 0.5% of epigenetic modifications.…”

Section: Discussionmentioning

confidence: 94%

Effects of the FOXO3a rs 4946936 Gene Polymorphism on the FOXO3a Transcription Factor in Chronic Granulocytic Leukemia Patients

Wardhani

Susianti²,

Rahayu³

et al. 2021

Open Access Maced J Med Sci

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Introduction : FOXO3a has an important role in the maintenance of leukemic stem cells. BCR-ABL inhibition therapy by TKI dasatinib aims to reduce the phosphorylation of the transcription factor FOXO3a, promote localization of FOXO3a in the nucleus and restore transcriptional activity. However, some studies showed that the TKI dasatinib, in addition to increase the relocation of Foxo3a to the intranuclear, also increase the expression of CDKN1c/p57 and Bcl6 genes that became the down target for Foxo3a intra nucleus ATM. Therefore, current therapy is mostly directed at personalized therapy (personalized medicine). The aim of this study was to investigate the effect of the FOXO3a rs4946936 gene polymorphism on the Foxo3a transcription factor in chronic granulocytic leukemia patients treated with Imatinib mesylate. Method : This is a cross-sectional study in patients with chronic granulocytic leukemia (CGL) with positive Bcr-ABL. The aim was to prove the effect of the FOXO3a gene polymorphism rs4946936 on the Foxo3a transcription factor. The data analysis test used was a correlation test and a regression test. Result : There were three polymorphisms of the FOXO3a gene, namely CC polymorphism, TC polymorphism, and TT polymorphism with a p-value of 0.026 and an r of 0.287, so it can be concluded that there was a significant correlation between the FOXO3a gene polymorphism and the Foxo3an transcription factor with a sufficient correlation value. In the regression test between the FOXO3a gene polymorphisms and the transcription factor FOXO3a, the p value was 0.029 and the B value was -0.294. This means that it has a negative and significant effect on the Foxo3a transcription factor variable. Conclusion : There was a significant correlation between the gene polymorphism FOXO3a rs4946936 and the transcription factor FOX3a. The FOXO3a gene polymorphism of the TT genotype had a negative effect on the FOXO3a transcription factor. The TT gene in the FOXO3a gene polymorphism was the most effective in reducing the FOXO3a transcription factor.

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Section: Discussionmentioning

confidence: 94%