Role of physical activity and sport in oncology

Bouillet, T.; Bigard, X.; Brami, Cloé; Chouahnia, K.; Copel, Laure; Dauchy, Sarah; Delcambre, Corinne; Descotes, Jean-Marc; Joly, Florence; Lepeu, G.; Marre, A.; Scotte, F.; Spano, Jean Philippe; Vanlemmens, Laurence; Zelek, Laurent

doi:10.1016/j.critrevonc.2014.12.012

Cited by 63 publications

(21 citation statements)

References 84 publications

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“…There were no SAEs and all patients completed the entire, intensive one-week program. Despite fear of epileptic seizures sometimes found in the literature [9,10], none occurred.…”

Section: Feasibility Safety and Adverse Eventsmentioning

confidence: 82%

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Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Troschel

Ramroth

Lemcke

et al. 2020

JCM

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A brain tumor diagnosis poses a significant psychological burden and it severely impacts quality of life (QOL), both in patients and relatives. However, comprehensive strategies addressing QOL in this setting remain rare. Here, we aim to share our findings of a one-week ski exercise intervention, with emphasis on feasibility, safety, QOL, and physical exercise. The intervention consisted of week-long daily ski sessions with professional ski guides as well as dedicated physicians present. The participants were handed questionnaires, including distress and QOL items before, during, and after the intervention. Using fitness watches, exercise intensity was also tracked at these timepoints. During the intervention, patients were checked for adverse events daily. Fifteen participants, nine patients after multidisciplinary treatment, and six relatives were included in the study. Additionally, 13 children participated in the exercise, but not in the study. All of the participants completed the entire program. No severe adverse events were documented during daily checks. There was a strong increase in quantified activity and QOL with a corresponding decrease in distress during the intervention, and, partly, afterwards. This prospective brain tumor rehabilitation study demonstrates the feasibility and safety of challenging ski exercise in brain tumor patients. The findings also underline the exercise-mediated QOL benefits, emphasizing the need for more comprehensive brain tumor rehabilitation programs.

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“…There were no SAEs and all patients completed the entire, intensive one-week program. Despite fear of epileptic seizures sometimes found in the literature [9,10], none occurred.…”

Section: Feasibility Safety and Adverse Eventsmentioning

confidence: 82%

“…Exercise has only rarely been offered to brain tumor patients due to caregivers' fear of epileptic seizures and falls [9,10]. The German GBM guidelines explicitly discourage exercise in this patient cohort [11].…”

Section: Introductionmentioning

confidence: 99%

Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Troschel

Ramroth

Lemcke

et al. 2020

JCM

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“…This agrees with many prospective trials, where less than one-third of eligible patients participate. 4 This pilot’s potential maximum (according to Table 2 , given perceived cancer-related issues precluding participation) includes an additional 37 patients for a total of 72 (35+37) or 58% (72/124). The highest participation rate in the literature was 82% using inpatients in a 4-week program.…”

Section: Discussionmentioning

confidence: 99%

“… 3 Similarly, active individuals with early-stage cancer have a lower risk of cancer relapse. 4 Exercise may have anticancer effects similar to standard systemic treatments; 3 however, this is yet to be proven in prospective randomized trials. The anticancer effect of exercise may be most easily seen in the metastatic setting, similar to the evaluation of investigational systemic treatments.…”

Section: Introductionmentioning

confidence: 99%

A structured group exercise program for patients with metastatic cancer receiving chemotherapy and CTNNB1 (β-catenin) as a biomarker of exercise efficacy

Chiarotto¹,

Akbarali²,

Bellotti³

et al. 2017

CMAR

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IntroductionExercise can improve the symptoms of cancer. However, is it a cancer treatment? We tested the feasibility of group exercise for metastatic cancer patients while on chemotherapy. A biomarker for exercise efficacy in colorectal cancer (CRC), β-catenin, was tested.MethodsPatients undergoing palliative chemotherapy were eligible for a pre–post, single-arm study comprising an indefinite, weekly group exercise intervention using strength and aerobic training. The Functional Assessment of Chronic Illness Therapy (FACIT) and Piper Fatigue Scale (PFS) questionnaires were administered, and aerobic capacity assessed using the 6-minute walk test. Selection bias, as measured by invitation rate, as well as participation, compliance, and attrition rates, was measured. CRC patients had surgical sections stained for β-catenin and correlated to survival. The statistical analysis was primarily exploratory and hypothesis generating.ResultsOf the 124 eligible patients, 53 (43%) patients were invited and 35 (28%) patients participated. The median number of classes attended was 16, the compliance rate was 73.1% (95% confidence interval [CI] 67.0–79.4), and the modified attrition rate was 24%. There were no injuries. No significant improvements were seen in the FACIT or PFS at 30 weeks. Aerobic capacity significantly improved at 30 weeks. Participation of CRC patients in the exercise pilot vs nonparticipation was not associated with a change in survival (hazard ratio [HR] =0.98, 95% CI 0.32–2.97). For all CRC patients, strong nuclear staining for β-catenin, compared to weak, suggested a lower risk of mortality (HR =0.54, 95% CI 0.14–1.96). However, CRC participants in the exercise program with weak nuclear staining for β-catenin had a trend to lower mortality (HR =0.39, 95% CI 0.025–6.1).ConclusionExercise for patients with metastatic cancer receiving chemotherapy is feasible and safe. β-Catenin is a potential biomarker for exercise anticancer effect in CRC.

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“…However, there was a non-significant trend of reduced risk with increasing activity among individuals with three IGFBP promoters methylated (HR 0.90, 95 % CI (0.59–1.38), and HR 0.69 95 %, CI (0.33–1.03) for >30–90 and >90 min of activity per day, respectively; p trend=0.06) [19]. These suggestive results are important as IGF is central to inflammatory process associated with carcinogenesis [72] and should be evaluated in future studies. In addition, Gay et al reported no association between physical activity and MLH1 promoter methylation in a cross-sectional study of 185 colorectal cancer tumors from the EPIC-Norfolk study [73].…”

Section: Observational Studies On Physical Activity and Colorectal Nementioning

confidence: 99%

Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior

Hibler

2015

Curr Colorectal Cancer Rep

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Studies demonstrate that regular physical activity and, more recently, limited sedentary behavior are associated with reduced risk of colorectal neoplasia. However, the biological mechanisms of action for physical activity versus sedentary behavior are not clear. Epigenetic variation is suggested as a potential mechanism that would allow for independent, or possibly even synergistic, effects of activity and inactivity on colorectal epithelium. We describe the evidence for epigenetic variation as a link between physical activity and sedentary behavior in colorectal neoplasia risk. There are few studies that directly evaluate this relationship. However, the growing literature describes a variety of gene targets influenced by activity that are also important to colorectal neoplasia etiology. Future studies may identify epigenetic markers with translational significance in identifying high-risk individuals or those for whom a personalized activity regimen could significantly alter the methylation signature in colon epithelial cells, and thus future risk of colorectal cancer.

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Role of physical activity and sport in oncology

Cited by 63 publications

References 84 publications

Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

A structured group exercise program for patients with metastatic cancer receiving chemotherapy and CTNNB1 (β-catenin) as a biomarker of exercise efficacy

Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior

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Role of physical activity and sport in oncology

Cited by 63 publications

References 84 publications

Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

A structured group exercise program for patients with metastatic cancer receiving chemotherapy and CTNNB1 (&beta;-catenin) as a biomarker of exercise efficacy

Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior

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Product

Resources

About

A structured group exercise program for patients with metastatic cancer receiving chemotherapy and CTNNB1 (β-catenin) as a biomarker of exercise efficacy