Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Troschel, Fabian M.; Ramroth, Christian; Lemcke, Lars; Clasing, Jens; Troschel, Amelie S.; Dugas, Martin; Stummer, Walter; Wiewrodt, Rainer; Brandt, Ralf; Wiewrodt, Dorothee

doi:10.3390/jcm9041006

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…This points to a high patient-specific depressive symptom burden and is a 5–10% higher ratio than pre-COVID brain tumor patient studies found [ 25 , 26 , 27 , 28 ]. Interestingly, the same is not true for anxiety, where our findings match the range defined by these previous studies [ 28 , 29 , 30 ]. Independent from this, absolute HADS values continue to be widely elevated relative to the general population [ 14 ] and point to a need for broad psychooncological screening among brain tumor patients.…”

Section: Discussionsupporting

confidence: 84%

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Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic

Troschel

Ahndorf

Wille

et al. 2021

Cancers

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The COVID-19 pandemic is associated with significant morbidity, mortality, and restrictions on everyday life worldwide. This may be especially challenging for brain tumor patients given increased vulnerability due to their pre-existing condition. Here, we aimed to investigate the quality of life (QoL) in brain tumor patients and relatives in this setting. Over twelve weeks during the first wave of the pandemic (04–07/2020), brain tumor patients and their families from two large German tertiary care centers were asked to complete weekly questionnaires for anxiety, depression, distress, and well-being. Information regarding social support and living conditions was also collected. One hundred participants (63 patients, 37 relatives) completed 729 questionnaires over the course of the study. Compared to relatives, patients showed more depressive symptoms (p < 0.001) and reduced well-being (p = 0.013). While acceptance of lockdown measures decreased over time, QoL remained stable. QoL measures between patients and their families were weakly or moderately correlated. The number of social contacts was strongly associated with QoL. Age, living conditions, ongoing therapy, employment, and physical activity were other predictors. QoL is correlated between patients and their families and heavily depends on social support factors, indicating the need to focus on the entire family and their social situation for QoL interventions during the pandemic.

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Section: Discussionsupporting

confidence: 84%

“…Finally, well-being was decreased by about 10% compared to pre-intervention levels of a previous QoL study at one of our centers [ 29 ].…”

Section: Discussionmentioning

confidence: 74%

Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic

Troschel

Ahndorf

Wille

et al. 2021

Cancers

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Sarcopenia is associated with chemoradiotherapy discontinuation and reduced progression-free survival in glioblastoma patients

Troschel,

Kloss

et al. 2024

Strahlenther Onkol

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Purpose Sarcopenia may complicate treatment in cancer patients. Herein, we assessed whether sarcopenia measurements derived from radiation planning computed tomography (CT) were associated with complications and tumor progression during radiochemotherapy for glioblastoma. Methods Consecutive patients undergoing radiotherapy planning for glioblastoma between 2010 and 2021 were analyzed. Retrocervical muscle cross-sectional area (CSA) was measured via threshold-based semi-automated radiation planning CT analysis. Patients in the lowest sex-specific quartile of muscle measurements were defined as sarcopenic. We abstracted treatment characteristics and tumor progression from the medical records and performed uni- and multivariable time-to-event analyses. Results We included 363 patients in our cohort (41.6% female, median age 63 years, median time to progression 7.7 months). Sarcopenic patients were less likely to receive chemotherapy (p < 0.001) and more likely to be treated with hypofractionated radiotherapy (p = 0.005). Despite abbreviated treatment, they more often discontinued radiotherapy (p = 0.023) and were more frequently prescribed corticosteroids (p = 0.014). After treatment, they were more often transferred to inpatient palliative care treatment (p = 0.035). Finally, progression-free survival was substantially shorter in sarcopenic patients in univariable (median 5.1 vs. 8.4 months, p < 0.001) and multivariable modeling (hazard ratio 0.61 [confidence interval 0.46–0.81], p = 0.001). Conclusion Sarcopenia is a strong risk factor for treatment discontinuation and reduced progression-free survival in glioblastoma patients. We propose that sarcopenic patients should receive intensified supportive care during radiotherapy and during follow-up as well as expedited access to palliative care.

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Cervical body composition on radiotherapy planning computed tomography scans predicts overall survival in glioblastoma patients

Troschel¹,

cand²,

cand³

et al. 2023

Clinical and Translational Radiation Oncology

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Feasibility, Safety and Effects of a One-Week, Ski-Based Exercise Intervention in Brain Tumor Patients and Their Relatives: A Pilot Study

Cited by 4 publications

References 41 publications

Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic

Quality of Life in Brain Tumor Patients and Their Relatives Heavily Depends on Social Support Factors during the COVID-19 Pandemic

Sarcopenia is associated with chemoradiotherapy discontinuation and reduced progression-free survival in glioblastoma patients

Cervical body composition on radiotherapy planning computed tomography scans predicts overall survival in glioblastoma patients

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