Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior

Hibler, Elizabeth A.

doi:10.1007/s11888-015-0296-z

Cited by 14 publications

(11 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prospective and population-based studies have demonstrated a direct relationship between a sedentary lifestyle and the risk of developing breast cancer [23,27,29,30]. However, this correlation may vary with age, menopausal status, and tumor biology [23,27,28,29,30,31,32,33,34,35]. In this study, the association was strongly inversed for both menopausal status and age.…”

Section: Discussionmentioning

confidence: 52%

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

et al. 2019

View full text Add to dashboard Cite

Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.

show abstract

Section: Discussionmentioning

confidence: 52%

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…However, recent data point to epigenetic factors, that is DNA modifications that do not alter the nucleotide sequence but still influence gene expression and may also be heritable as important factors specifically for colorectal neoplasia. These mechanisms include modifications of histones, non-coding RNA such as microRNA (miRNA) expressions, and DNA methylation variations [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway

et al. 2018

View full text Add to dashboard Cite

BackgroundSedentary behavior is thought to pose different risks to those attributable to physical inactivity. However, few studies have examined the association between physical activity and sitting time with cancer incidence within the same population.MethodsWe followed 38,154 healthy Norwegian adults in the Nord-Trøndelag Health Study (HUNT) for cancer incidence from 1995–97 to 2014. Cox proportional hazards regression was used to estimate risk of site-specific and total cancer incidence by baseline sitting time and physical activity.ResultsDuring the 16-years follow-up, 4,196 (11%) persons were diagnosed with cancer. We found no evidence that people who had prolonged sitting per day or had low levels of physical activity had an increased risk of total cancer incidence, compared to those who had low sitting time and were physically active. In the multivariate model, sitting ≥8 h/day was associated with 22% (95% CI, 1.05–1.42) higher risk of prostate cancer compared to sitting <8 h/day. Further, men with low physical activity (≤8.3 MET-h/week) had 31% (95% CI, 1.00–1.70) increased risk of colorectal cancer (CRC) and 45% (95% CI, 1.01–2.09) increased risk of lung cancer compared to participants with a high physical activity (>16.6 MET-h/week). The joint effects of physical activity and sitting time the indicated that prolonged sitting time increased the risk of CRC independent of physical activity in men.ConclusionsOur findings suggest that prolonged sitting and low physical activity are positively associated with colorectal-, prostate- and lung cancer among men. Sitting time and physical activity were not associated with cancer incidence among women. The findings emphasizing the importance of reducing sitting time and increasing physical activity.

show abstract

“…Epigenetic variation could therefore be a potential mechanism allowing for independent or synergistic effects of physical inactivity on platelet function. Hibler et al recently described indications for epigenetic variation (by miRNA expression) as a link between physical activity and sedentary lifestyle [139]. An epigenetic adaptation to habitual exercise has been described [140,141].…”

Section: Physical Activity/inactivity-specific Mirnamentioning

confidence: 99%

Platelets: Functional Biomarkers of Epigenetic Drift

Twomey¹,

Wallace²,

Mangone³

et al. 2019

Homeostasis - An Integrated Vision

View full text Add to dashboard Cite

Cardiovascular disease (CVD) risk factors can be classed as modifiable or non-modifiable. Physical inactivity and obesity represent major behavioural risk factors for the initiation, development and progression of CVD. Platelet dysfunction is pivotal to the aetiology of CVD, a chronic vascular inflammatory condition, which is characterised by a lag time between onset and clinical manifestation. This indicates the role of epigenetic drift, defined by stochastic patterns of gene expression not dependent on dynamic changes in coding DNA. The epigenome, a collection of chemical marks on DNA and histones, is established during embryogenesis and modified by age and lifestyle. Biogenesis and effector function of non-coding RNA, such as microRNA, play a regulatory role in gene expression and thus the epigenetic mechanism. In this chapter, we will focus on the effect of the modifiable risk factors of physical activity/inactivity and overweight/obesity on platelet function, via epigenetic changes in both megakaryocytopoiesis and thrombopoiesis. We will also discuss the role of acute exercise on platelet function and the impact of cardiorespiratory fitness (CRF) on platelet responses to acute exercise. This chapter will highlight the potential role of platelets as circulating functional biomarkers of epigenetic drift to implement, optimise and monitor CVD preventive management strategies.

show abstract

Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior

Cited by 14 publications

References 95 publications

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway

Platelets: Functional Biomarkers of Epigenetic Drift

Contact Info

Product

Resources

About