The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway

Rangul, Vegar; Sund, Erik R.; Mork, Paul Jarle; Røe, Oluf Dimitri; Bauman, Adrian

doi:10.1371/journal.pone.0206015

Cited by 28 publications

(24 citation statements)

References 43 publications

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“…Myriad of cardiometabolic risks, alterations in physiological systems determining future chronic diseases were found. [9][10][11][12][13][14] Four reviews 9,10,12,13 and two randomized controlled trials 11,15 have established cardiometabolic risks such as hyperglycemia, hypertension, altered triglycerides and body mass index due to sedentary behaviour.…”

Section: Resultsmentioning

confidence: 99%

Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review

Chandrasekaran

Ganesan

2020

Scott Med J

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Background & Aims Though viewed as a critical measure to prevent the spread of the virus, a prolonged homestay may result in unfavourable sedentary behaviour and chronic disease risk. This systematic review focuses on sedentary behaviour resulting from this quarantine period which may elevate the cardiovascular disease risk, obesity, hypertension, cancer and mental health illness. Methods Evidence of breaking sedentary behaviour and global recommendations were investigated. Potential unanswered questions regarding sedentary behaviour and physical activity during lockdown were explored. Results Five systematic reviews and six prospective trials explored the effect of sedentarism affecting chronic disease through potential pathophysiological mechanisms. Sedentary behaviour especially prolonged sitting is found to be a pleiotropic risk factor with altered energy expenditure, adipogenic signalling, immunomodulation, autonomic stability and hormonal dysregulation perpetuating underlying chronic diseases such as obesity, cardiovascular disease, cancer and mental health disorders. Conclusion Breaking sitting and physical activity are found to reverse the adverse effects associated with excessive sitting during the lockdown.

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Section: Resultsmentioning

confidence: 99%

Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review

Chandrasekaran

Ganesan

2020

Scott Med J

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“…We assessed 23 full-text articles for eligibility. Of these, seven studies used incompatible study designs (meta-analyses or systematic reviews) [4,[8][9][10][29][30][31], five studies investigated other exposure variables (physical activity or physical inactivity) [32][33][34][35][36], two studies did not provide sufficient data on ovarian cancer risk [37,38] and two studies were updated by a more recent publication [39,40] (Online Resource 3). After exclusion of these studies, a total of seven eligible articles, containing three prospective cohort studies [14,16,18] and four case-control studies [13,15,17,19], were included in our systematic review and meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis

et al. 2021

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Sedentary behaviour is an emerging risk factor for several site-specific cancers. Ovarian cancers are often detected at late disease stages and the role of sedentary behaviour as a modifiable risk factor potentially contributing to ovarian cancer risk has not been extensively examined. We systematically searched relevant databases from inception to February 2020 for eligible publications dealing with sedentary behaviour in relation to ovarian cancer risk. We conducted a systematic review and meta-analysis, calculating summary relative risks (RR) and 95% confidence intervals (CI) using a random-effects model. We calculated the E-Value, a sensitivity analysis for unmeasured confounding. We tested for publication bias and heterogeneity. Seven studies (three prospective cohort studies and four case–control studies) including 2060 ovarian cancer cases were analysed. Comparing highest versus lowest levels of sedentary behaviour, the data indicated a statistically significant increase in the risk of ovarian cancer in relation to prolonged sitting time (RR = 1.29, 95% CI = 1.07–1.57). Sub-analyses of prospective cohort studies (RR = 1.33, 95% CI = 0.92–1.93) and case–control studies (RR = 1.28, 95% CI = 0.98–1.68) showed statistically non-significant results. Sensitivity analysis showed that an unmeasured confounder would need to be related to sedentary behaviour and ovarian cancer with a RR of 1.90 to fully explain away the observed RR of 1.29. Our analyses showed a statistically significant positive association between sedentary behaviour and ovarian cancer risk.

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“…Engagement in outdoor activity influences levels of inactivity and sedentarism, both of which are contributors to chronic diseases [ 35 , 36 ] The joint association between PA and sedentary behaviour has been intensively explored in the past decade [ 37 ]. Rangul et al [ 38 ] found no evidence that people who spend prolonged periods seated or who have low levels of PA have an increased risk of total cancer incidence when compared to people who spend short periods seated or who are physically active. Autenrieth et al [ 39 ] found that PA during leisure time is associated with cancer-related mortality, and vigorous activity with CVD-related mortality.…”

Section: Discussionmentioning

confidence: 99%

Association of engagement in cultural activities with cause-specific mortality determined through an eight-year follow up: The HUNT Study, Norway

et al. 2021

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Participation in cultural activities may protect against cause-specific mortality; however, there is limited knowledge regarding this association. The present study examines the association between participation in a range of receptive and creative cultural activities and risk of cardiovascular disease- and cancer-related mortality. We also examined whether participation in such activities and influence by gender have on this association. We followed 35,902 participants of the Nord-Trøndelag Health Study (HUNT3) of Cardiovascular-Disease and Cancer Mortality from 2006–08 to 2016. Cox proportional-hazards regression was used to estimate the risk of specific mortality based on baseline cultural participation. During the eight-year follow-up, there were 563 cardiovascular-disease- and 752 cancer-related deaths among the sample (292,416 person years). Risk of cardiovascular-disease mortality was higher among non-participants in associations/club meetings (22%) and outdoor activities (23%), respectively, as well as non-attendees of art exhibitions (28%). People who engaged in music, singing, and theatre had a 27% reduced risk of cancer-related mortality when compared to non-participants. Among women, participating in associations/club meetings reduced the risk of cardiovascular-disease mortality by 36%. Men who participated in music, singing, and theatre had a 33% reduced risk of cancer mortality. Overall, a reduced risk of cardiovascular-disease mortality was associated with engaging in creative activities on weekly basis to less than twice per week. For both genders, participating in creative activities less than once a week reduced cardiovascular-disease mortality risk by 40% and 33%, respectively. For the overall sample, participating > 2 times per week in combined receptive and creative activities reduced cancer-related mortality by 29%. Participating frequently in both receptive and creative activities cultural activities was associated with lower risks of CVD and cancer-related mortality. Our data suggest that, to counteract the public health burden of cardiovascular disease- and cancer mortality, policies and initiatives to increase citizens’ participation in cultural activities should be considered.

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The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway

Cited by 28 publications

References 43 publications

Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review

Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review

Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis

Association of engagement in cultural activities with cause-specific mortality determined through an eight-year follow up: The HUNT Study, Norway

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