Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis

Abstract

Sedentary behaviour is an emerging risk factor for several site-specific cancers. Ovarian cancers are often detected at late disease stages and the role of sedentary behaviour as a modifiable risk factor potentially contributing to ovarian cancer risk has not been extensively examined. We systematically searched relevant databases from inception to February 2020 for eligible publications dealing with sedentary behaviour in relation to ovarian cancer risk. We conducted a systematic review and meta-analysis, calculating summary relative risks (RR) and 95% confidence intervals (CI) using a random-effects model. We calculated the E-Value, a sensitivity analysis for unmeasured confounding. We tested for publication bias and heterogeneity. Seven studies (three prospective cohort studies and four case–control studies) including 2060 ovarian cancer cases were analysed. Comparing highest versus lowest levels of sedentary behaviour, the data indicated a statistically significant increase in the risk of ovarian cancer in relation to prolonged sitting time (RR = 1.29, 95% CI = 1.07–1.57). Sub-analyses of prospective cohort studies (RR = 1.33, 95% CI = 0.92–1.93) and case–control studies (RR = 1.28, 95% CI = 0.98–1.68) showed statistically non-significant results. Sensitivity analysis showed that an unmeasured confounder would need to be related to sedentary behaviour and ovarian cancer with a RR of 1.90 to fully explain away the observed RR of 1.29. Our analyses showed a statistically significant positive association between sedentary behaviour and ovarian cancer risk.

Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model

“…For neoplasms, we only found suggestive evidence about the associations of sedentary time with lung, breast and endometrium cancer before multiple correction, which were generally similar to a recent review that sedentary time, independent of physical activity, has been shown to increase the risk of colon, endometrial, and lung cancers. 27 Previous studies also demonstrated no significant associations with multiple site-specific cancer, such as ovary, 28 prostate, 29 oesophago gastric, 30 colorectal cancer. 13 Moreover, a meta-analysis including 43 observational studies almost presented consistent associations between sedentary time and site-specific cancers.…”

Sedentary behavior and cancer–an umbrella review and meta-analysis

“…For cancer incidence of individual sites, we included ten [ 7 – 9 , 11 , 35 , 49 – 53 ] meta-analyses with a total of 212,707 cancer cases and 17 different cancer sites from 77 individual studies (50 cohort and 27 case–control studies). Of those eleven meta-analyses, ten showed a statistically significant association with cancer incidence.…”

Risks of Digital Screen Time and Recommendations for Mitigating Adverse Outcomes in Children and Adolescents

“…5 Increased BMI in childhood has been demonstrated to increase the likelihood of obesity in adulthood, 68 which in turn increases the risk of developing noncommunicable diseases. Sedentary behavior has been positively associated with increased risk of disease later in life, 69 including type 2 diabetes, 70 diabetic retinopathy, 71 cancer, [72][73][74] dementia, 75 and cardiovascular disease. 70 Low levels of physical activity, low cardiorespiratory fitness, and sedentary behavior are significantly associated with the development of metabolic syndrome.…”