Sedentary behavior and cancer–an umbrella review and meta-analysis

Hermelink, Rafael; Leitzmann, Michael F.; Tsilidis, Kostas; Pukrop, Tobias; Berger, Felix; Baurecht, Hansjörg; Jochem, Carmen

doi:10.1007/s10654-022-00873-6

Cited by 41 publications

(30 citation statements)

References 88 publications

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“…Additionally, the sample size of this study was large enough to provide sufficient statistical validity for the detection of a convincing association. Notably, in addition to poor dietary habits, other risk factors such as obesity, smoking, alcohol consumption, sedentary behavior, and exposure to pesticides are also associated with an increased risk of CRC [ 71 , 72 , 73 , 74 , 75 ]. We excluded the effect of these risk factors mainly by adjusting them as confounding factors in the multivariable models.…”

Section: Discussionmentioning

confidence: 99%

Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China

Zhou

et al. 2022

Nutrients

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Associations of dietary fatty acids with the risk of colorectal cancer (CRC) remain controversial. The objective of this study was to examine whether dietary-derived fatty acid patterns were related to CRC risk among Chinese people. A total of 2806 CRC patients and 2806 frequency-matched controls were interviewed in this case-control study between July 2010 and May 2021. A food frequency questionnaire was used to gather information on dietary intake. Four fatty acid patterns were identified using factor analysis. The even-long-chain fatty acid pattern had no statistically significant association with CRC risk (adjusted Odds ratio (aOR), 1.16; 95% confidence interval (CI), 0.97–1.39; ptrend = 0.129). However, significant inverse associations were found between the medium-chain and long-chain saturated fatty acid (SFA) pattern (aOR, 0.34; 95%CI, 0.27–0.42), the highly unsaturated fatty acid pattern (aOR, 0.73; 95%CI, 0.60–0.88), the odd-chain fatty acid pattern (aOR, 0.69; 95%CI, 0.57–0.83), and CRC risk. The interaction between fatty acid patterns and sex was observed, and the association between the highly unsaturated fatty acid pattern and CRC risk differed by subsite. In conclusion, increasing the intakes of foods rich in medium-chain SFAs, highly unsaturated fatty acids, and odd-chain fatty acids may be related to a lower risk of CRC.

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Section: Discussionmentioning

confidence: 99%

Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China

Zhou

et al. 2022

Nutrients

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“…found sedentary time measured by the ActiGraph GT3X was not associated with fatigue. Several reviews have suggested sedentary time is associated with increased cancer mortality 35,36 but consistent evidence implicating sedentary time in adverse QOL and other PROs has not emerged. Inconsistent results across these studies may be due to key methodological differences.…”

Section: Discussionmentioning

confidence: 99%

Associations of device‐measured physical activity and sedentary time with quality of life and fatigue in newly diagnosed breast cancer patients: Baseline results from the AMBER cohort study

Vallance

Friedenreich

Wang

et al. 2022

Cancer

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Background This study examined associations of device‐measured physical activity and sedentary time with quality of life (QOL) and fatigue in newly diagnosed breast cancer patients in the Alberta Moving Beyond Breast Cancer (AMBER) cohort study. Methods After diagnosis, 1409 participants completed the SF‐36 version 2 and the Fatigue Scale, wore an ActiGraph device on their right hip to measure physical activity, and an activPAL device on their thigh to measure sedentary time (sitting/lying) and steps. ActiGraph data was analyzed using a hybrid machine learning method (R Sojourn package, Soj3x) and activPAL data were analyzed using activPAL algorithms (PAL Software version 8). Quantile regression was used to examine cross‐sectional associations of QOL and fatigue with steps, physical activity, and sedentary hours at the 25th, 50th, and 75th percentiles of the QOL and fatigue distributions. Results Total daily moderate and vigorous physical activity (MVPA) hours was positively associated with better physical QOL at the 25th (β = 2.14, p = <.001), 50th (β = 1.98, p = <.001), and 75th percentiles (β = 1.25, p = .003); better mental QOL at the 25th (β = 1.73, p = .05) and 50th percentiles (β = 1.07, p = .03); and less fatigue at the 25th (β = 4.44, p < .001), 50th (β = 3.08, p = <.001), and 75th percentiles (β = 1.51, p = <.001). Similar patterns of associations were observed for daily steps. Total sedentary hours was associated with worse fatigue at the 25th (β = −0.58, p = .05), 50th (β = −0.39, p = .06), and 75th percentiles (β = −0.24, p = .02). Sedentary hours were not associated with physical or mental QOL. Conclusions MVPA and steps were associated with better physical and mental QOL and less fatigue in newly diagnosed breast cancer patients. Higher sedentary time was associated with greater fatigue symptoms.

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“…In recent years, researchers have begun to focus on the significance of modifiable behavioral factors in cancer development and progression, particularly the potential associations among SB, PA, and cancer. Numerous epidemiological studies have found that appropriate PA reduces the risk and improves the prognosis of several cancers, while SB has the exact opposite effect ( 10 , 11 ). Nevertheless, SB and low PA levels are becoming increasingly common in modern lifestyles, both in the healthy population and among cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of global research on physical activity and sedentary behavior in the context of cancer

Chen

et al. 2023

Front. Oncol.

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ObjectiveNumerous studies focusing on sedentary behavior (SB) and physical activity (PA) in the context of cancer have been reported in recent years. We analyzed and visualized studies on SB and PA in patients with cancer over the last 20 years using scientometric methods, to provide insights on gaps and deficiencies in the literature, and to inform future research guidelines.MethodsAll relevant studies in the field from 2001 to October 2022 were reviewed using bibliometric tools, including VOSviewer, Bibliometric online analysis platform, and biblioshiny, to determine the most influential countries, institutions, journals, and authors. We explored current research hotpots and potential research trends, based on keyword clustering and dynamic changes. Our research focuses on PA, SB, and cancer across the entire cancer continuum, from primary prevention to treatment to cancer survivorship.ResultsScientometric analysis identified 4,382 relevant manuscripts on SB and PA in the context of cancer, with a 10-fold increase in articles over the past 20 years. The United States, Canada, and Australia were the most influential countries. The journal, Supportive Care in Cancer, had the highest number of publications, while Clinical Oncology had the highest H-index. K.S. Courneya was the most influential author in this field, with the highest number of publications, total citations, and H-index. Keyword analysis revealed that current research is focused on PA and SB in patients with breast cancer, quality of life, and aerobic exercise. Future frontiers include cancer prehabilitation programs and cardiorespiratory fitness, and remote intervention and social support.ConclusionBy using bibliometrics, we conducted a comprehensive review of SB and PA in cancer-related studies. The current research focused on exercise and sedentariness in breast cancer patients and the role of PA in improving quality of life in survivorship. Emerging research foci were generally around cancer prehabilitation programs and remote intervention issues for PA. In addition, some publication deficits are noted: studies of PA and SB in less common cancers; the recommended doses and intensities of exercise for cancer; the timing of interventions for prehabilitation and the establishment of individualized exercise protocols. These deficiencies align with the needs for future research topics.

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Sedentary behavior and cancer–an umbrella review and meta-analysis

Cited by 41 publications

References 88 publications

Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China

Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China

Associations of device‐measured physical activity and sedentary time with quality of life and fatigue in newly diagnosed breast cancer patients: Baseline results from the AMBER cohort study

Bibliometric analysis of global research on physical activity and sedentary behavior in the context of cancer

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