Role of Omega-3-Fatty Acids in the Management of Diabetes and Associated Complications

Behl, Tapan; Grover, Madhuri; Shah, Karan Bahadur; Makkar, Rashita; Kaur, Loveleen; Sharma, S. B.; Gupta, Jyoti

doi:10.1016/b978-0-12-813822-9.00012-6

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…This may be relevant if an approach of dietary supplementation of relevant parent fatty acids, with or without sEH inhibition, might be used with the former combination testing for potential synergistic effects [ 7 ], [ 81 ]. The type of fat intake may affect diabetes complications [ 12 ], so trials and observational studies should consider intake of specific parent fatty acids (e.g., EPA, DHA, AA) in examining dietary effects on diabetes complications. The Mediterranean diet, which is high in unsaturated fats and nitrogen-rich vegetables, has been associated with the production of nitrolipid species which inhibited sEH to reduce blood pressure [ 91 , 92 ].…”

Section: Synthesis and Clinical Translationmentioning

confidence: 99%

“…Lipid metabolism is altered profoundly in patients with T2DM, while the amount and type of fat intake can also affect diabetes complications [ 5 , 12 ]. Insulin resistance can lead to increased lipolysis in the adipocytes, leading to enhanced availability of fatty acids and subsequent oxidative metabolism into bioactive mediators (oxylipins).…”

Section: Introductionmentioning

confidence: 99%

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Soluble Epoxide Hydrolase and Diabetes Complications

Anita

Swardfager

2022

IJMS

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Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to macrovascular complications, such as heart failure, peripheral arterial disease, and large vessel stroke. T2DM also increases the risks of depression and dementia for reasons that remain largely unclear. Perturbations in the cytochrome P450-soluble epoxide hydrolase (CYP-sEH) pathway have been implicated in each of these diabetes complications. Here we review evidence from the clinical and animal literature suggesting the involvement of the CYP-sEH pathway in T2DM complications across organ systems, and highlight possible mechanisms (e.g., inflammation, fibrosis, mitochondrial function, endoplasmic reticulum stress, the unfolded protein response and autophagy) that may be relevant to the therapeutic potential of the pathway. These mechanisms may be broadly relevant to understanding, preventing and treating microvascular complications affecting the brain and other organ systems in T2DM.

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Section: Synthesis and Clinical Translationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Soluble Epoxide Hydrolase and Diabetes Complications

Anita

Swardfager

2022

IJMS

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“…Diyabette ikincil korumanın sağlanması ve hipertansiyon, atrial fibrilasyon, inme gibi durumların önlenmesinde de omega yağ asitlerinin rol oynadığı düşünülmektedir. Omega-3 desteği ile doğrudan glisemik kontrol etkinliği tespit edilememiş olsa da hayvan deneylerinde insülin duyarlılığını arttırarak glisemik kontrolün sağlandığı da gözlenmiştir [42,43]…”

Section: Kardiyovasküler Sistem üZerine Etkileriunclassified

Omega Yağ Asitleri: Biyolojik Etkileri ve Bitkisel Kaynakları

Salar¹,

Uz²

2021

Hacettepe University Journal of the Faculty of Pharmacy

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Review ArticleÖZET Diyetin önemli bileşenlerinden olan omega yağ asitleri yaygın olarak omega-3, omega-6, omega-9 olarak bilinmektedir. Omega yağ asitlerinin en zengin besin kaynakları bitkisel yağlar ve balık yağlarıdır. Omega-3 ve omega-6 zorunlu olarak dışarıdan alınması gereken esansiyel yağ asitlerindendir. Omega-3, α-linolenik asit (ALA) bitkisel kaynaklı iken; eikosapentaenoik asit (EPA) ve dokosaheksaenoik asit (DHA) balıklarda bol miktarda bulunmaktadır. Bitkilerin tohumları ve özellikle fındık, ceviz gibi sert kabuklu meyveler başlıca omega yağ asidi kaynaklarıdır. Başta omega-3 olmak üzere omega yağ asitlerinin kardiyovasküler hastalıklar, bilişsel fonksiyonlar, metabolik bozukluklar, enflamatuvar hastalıklar, oksidatif stres, cilt rahatsızlıkları, göz hastalıkları, psikiyatrik bozukluklar ve Alzheimer gibi birçok hastalıkta olumlu etkileri vardır ve tedavide kullanılmaktadırlar. Ayrıca fetal gelişimin sağlanmasında da etkin rol oynadıkları bilinmektedir. Sağlık üzerindeki yararlı etkilerin görülebilmesi için omega-6/omega-3 oranının düşük olması gerekmektedir. Biyolojik etkilerinin birçoğunun mekanizması henüz tam olarak aydınlatılamamıştır. Bu makalede, önemli omega yağ asitleri hakkında genel bilgilerin, bulundukları bitkisel kaynakların, biyolojik etkilerinin ve kullanımlarının derlenmesi amaçlanmıştır

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“…In recent decades, scientists have conducted studies on the positive effects of nutrients available to different marine organisms on health, which may be the key to new treatments for diseases such as cancer (Correia et al, 2017;Gómez et al, 2019), neurodegenerative diseases (Gopal et al, 2008), human immunodeficiency virus (Güneş, 2013), or cardiovascular disease (Fidalgo et al, 2019;Norde et al, 2019). In addition, it provides other valuable components such as docosahexaenoic acid and eicosapentaenoic acid, both omega 3 (ω-3), important for optimal neurological development in children (Al-Ghannami et al, 2019;Coelho et al, 2019), diabetes (Behl et al, 2019) and epilepsy (Tejada et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Local Cuban bentonite clay as potential low-cost adsorbent for shark liver oil pool purification

Quero-Jiménez¹,

Felipe²,

García³

et al. 2021

J Pharm Pharmacogn Res

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Context: The shark liver of the species Ginglimostoma cirratun, Carcharhinus longimanus, and Carcharhinus falciformis, captured in the north-central coast of Cuba are a source of oil, that when extracted it must be purified due to its bad smell, taste and the amount of impurities it has. Aims: To evaluate the purification of the shark liver oil (SLO) pool of species Ginglimostoma cirratun, Carcharhinus longimanus, and Carcharhinus falciformis, by Cuban bentonite clay. Methods: The effects of bentonite dose, contact time and speed rate were studied using the 23 factorial designs. The parameters are evaluated in the experiment design: acidity value, p-anisidine value, peroxide value, Totox value and Bleaching performance. Response Surface Methodology modeling techniques were applied to model the process and their performance and predictive capabilities of the response (purification efficiency) was also examined. Results: The experiments showed that the oil is suitable for consumption after the purification process. The best treatment, which could reduce the impurities in the SLO pool, was a treatment with bentonite dose at 80 g/L, time at 15 min, and speed rate at 250 rpm. Cuban bentonite clay is a promising adsorbent candidate for the removal of impurities of the SLO. Conclusions: The local Cuban bentonite clay can be used as potential low-cost adsorbent for shark liver oil pool purification, as showed the experiments.

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Role of Omega-3-Fatty Acids in the Management of Diabetes and Associated Complications

Cited by 11 publications

References 43 publications

Soluble Epoxide Hydrolase and Diabetes Complications

Soluble Epoxide Hydrolase and Diabetes Complications

Omega Yağ Asitleri: Biyolojik Etkileri ve Bitkisel Kaynakları

Local Cuban bentonite clay as potential low-cost adsorbent for shark liver oil pool purification

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