Role of nitric oxide in wound repair

Witte, Maria; Barbul, Adrian

doi:10.1016/s0002-9610(02)00815-2

Cited by 438 publications

(292 citation statements)

References 60 publications

Supporting

Mentioning

280

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, some of these effects are likely to be similar to the activities of natural ROS and/or NO during wound healing, particularly cold plasma's effects on the proliferation of both fibroblasts and endothelial cells 19 . Therefore, the aim of this study was to assess the effects of cold plasma on acute cutaneous wound healing in an in vivo scenario with a focus on re-epithelialization and wound contraction.…”

Section: Introductionmentioning

confidence: 99%

“…The former is central to wound closure, which is closely connected to granulation tissue formation in a spatiotemporal manner 16 , and the latter may account for up to a 40% decrease in wound size, correlated with the expression of myofibroblasts 17 . It is well established that these processes are influenced by the presence of growth factors like epidermal 4 growth factor (EGF), keratinocyte growth factor (KGF) and transforming growth factor (TGF) 15 , which are likely mediated by reactive oxygen species (ROS) and NO [18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

View full text Add to dashboard Cite

We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1 minute, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by one day. Plasma may promote the late phase of inflammation, accelerate reepithelialization and increase wound contraction.3

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

View full text Add to dashboard Cite

show abstract

“…Synthesis of NO has been reported during the proliferative phase after wound formation. Increased iNOS expression release NO regulates collagen formation, cell proliferation, and wound contraction (Witte and Barbul, 2002). Moreover, iNOS regulates keratinocytes proliferation (Frank et al, 1998).…”

Section: Wound Healing Mechanisms Of Medicinal Plantsmentioning

confidence: 99%

Medicinal plants with wound healing potential

Firdous¹,

Sautya²

2018

Bangladesh J Pharmacol

View full text Add to dashboard Cite

show abstract

“…[3][4][5]17,[20][21][22][23][24] It has also been reported that nitric oxide (NO) produced by activation of the iNOS enzyme in monocytes participates in signaling for deposition of granulation tissue and collagen and for wound contraction (scar formation) via distinct pathways in animal models of wound healing. 3,14,15,17,21,24 Some authors also show biostimulation effects of LLLT on inflammatory cytokines through gene expression modulation of various growth factors such as platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), which are also potentially involved in the healing of skin wounds. 24.25 These regulatory effects of oxidative stress in skin, biomodulation of inflammatory cytokines and growth factors could be related to the histological findings observed in this study, in relation to the isolated treatment with LLLT (He -Ne).…”

Section: Photomicrograph Montage Of Skin Wounds In Micementioning

confidence: 99%

Uso combinado da laserterapia de baixa potência e da inibição da ciclooxigenase-2 na reepitelização de ferida incisional em pele de camundongos: um estudo pré-clínico

Santuzzi

Buss

Pedrosa³

et al. 2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

Abstract:BACKGROUND: Low level laser therapy and cyclooxygenase-2 (ICOX2) selective inhibitors have been widely used to modulate inflammatory response; however, their effect on wound reepithelialization are not well understood. OBJECTIVE: To evaluate the isolated and combined effects of low level laser therapy and ICOX2 in the reepithelization of skin incisional wounds in mice. METHODS: We induced a 1-cm wound on the back of each mouse, which were divided into four groups (N = 20): control, laser therapy, treated with celecoxib and combined therapy. The animals in the celecoxib and combined therapy groups were treated with celecoxib for 10 days before skin incision. The experimental wounds were irradiated with He-Ne low power laser (632nm, dose: 4J/cm2) in scanning for 12 seconds during three consecutive days in the laser therapy and combined therapy groups. The animals were sacrificed 3 days after surgery. Samples of the wounds were collected and stained (Masson's Trichrome) for histomorphometric analysis. RESULTS: Both the laser therapy group and the celecoxib group showed an increase in skin reepithelialization compared to the control group; however, the combined therapy group showed no differences. As for keratinization, the laser therapy and combined therapy groups showed a reduction in keratinocytes compared with the control group. CONCLUSION: The results show that the use of low level laser therapy and ICOX2 in isolation increases epithelial cells, but only low level laser therapy reduced skin keratinocytes. The combined treatment restores innate epithelialization and decreases keratinization in spite of accelerating wound contraction with improvement in the organization of the wound in the skin of mice. Keywords: Cyclooxygenase 2 inhibitors; Epithelial cells; Keratinocytes; Laser therapy; Wound healing Resumo: FUNDAMENTOS: A laserterapia de baixa potência e os inibidores seletivos da ciclooxigenase-2 (ICOX2) vem sendo muito utilizados para modular a resposta inflamatória, entretanto, os seus efeitos na reepitelização de feridas não são bem compreendidos. OBJETIVO: Avaliar os efeitos isolados e combinados da laserterapia de baixa potência e da ICOX2 na reepitelização de ferida incisional na pele de camundongos. MÉTODO: Foi induzida uma ferida de 1 cm no dorso de cada camundongo, que foram divididos em quatro grupos (N=20): Controle, Laserterapia, Tratados com celecoxib e Terapia conjugada. Os animais dos grupos celecoxib e Terapia conjugada foram tratados com celecoxib por 10 dias antes da incisão cutânea. As feridas experimentais foram irradiadas com laserterapia de baixa potência He-Ne (632nm, dose: 4J/cm2) em varredura, por 12 segundos durante três dias consecutivos nos grupos Laserterapia e Terapia conjugada. Os animais foram sacrificados no 3º dia de pós-operatório. Amostras das feridas foram coletadas e coradas (Tricromio de Masson) para análise histomorfométrica. RESULTADOS: Tanto o grupo Laserterapia, quanto o grupo celecoxib, mostrou aumento da reepitelização cutânea em relação ao grupo Controle,...

show abstract

Role of nitric oxide in wound repair

Cited by 438 publications

References 60 publications

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Medicinal plants with wound healing potential

Uso combinado da laserterapia de baixa potência e da inibição da ciclooxigenase-2 na reepitelização de ferida incisional em pele de camundongos: um estudo pré-clínico

Contact Info

Product

Resources

About