Role of neuron density of the stellate ganglion on regulation of the basilar artery volume in subarachnoid hemorrhage: An experimental study

Kayacı, Selim; Kanat, Ayhan; Aydın, Mehmet Dumlu; Müslüman, Ahmet Murat; Eseoglu, Mete; Karalar, Mustafa; Gündoğdu, Cemal

doi:10.1016/j.autneu.2011.06.008

Cited by 28 publications

(16 citation statements)

References 20 publications

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“…Most available information about neuronal injury after SAH comes from animal studies. 11,14 Our findings can be explained by OMN degeneration secondary to PComA vasospasm. If there is no PComA vasospasm, pupillary diameter changes cannot be seen.…”

Section: Limitations Of the Studymentioning

confidence: 76%

“…Vasospasm indices (VSIs) of PComAs supplying OMNs were estimated as in our former studies. 6,14 The vessel wall surface area value/lumen area volume were accepted as VSI and formulated as VSI ¼ (R 2 À r 2 )/r 2 . The Cavalieri volume estimation method was used to obtain the total number of axons in each OMN.…”

Section: Methodsmentioning

confidence: 99%

“…10,11 The changes of the autonomic nervous system following SAH have been well investigated. 5,6,[10][11][12][13][14][15][16][17][18] However, no study has been published regarding the effect of the posterior communicating artery (PComA) supplying OMN degeneration on pupillary diameter changes following SAH. In the present study, we hypothesized that axon density of OMNs may have an important role on the pupillary diameter following SAH, which has not been mentioned in the literature.…”

Section: Introductionmentioning

confidence: 99%

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How Reliable Is Pupillary Evaluation Following Subarachnoid Hemorrhage? Effect of Oculomotor Nerve Degeneration Secondary to Posterior Communicating Artery Vasospasm: First Experimental Study

Öztürk¹,

Özdemir²,

Kanat

et al. 2017

J Neurol Surg A Cent Eur Neurosurg

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Section: Limitations Of the Studymentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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How Reliable Is Pupillary Evaluation Following Subarachnoid Hemorrhage? Effect of Oculomotor Nerve Degeneration Secondary to Posterior Communicating Artery Vasospasm: First Experimental Study

Öztürk¹,

Özdemir²,

Kanat

et al. 2017

J Neurol Surg A Cent Eur Neurosurg

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“…High neuron density of the stellate ganglion can be considered as sympathetic overactivity that causes basilar vasospasm and neovascularisation, whereas low neuron density of stellate ganglion can be considered as sympathetic hypoactivity that prevents basilar vasospasm and causes vascular wall thinning after bilateral common carotid artery ligation (39).…”

Section: █ Discussionmentioning

confidence: 99%

Predictive role of external carotid artery vasospasm on cerebral ischemia in subarachnoid hemorrhage: experimental study

Ng¹,

Aydın²,

Yolaş³

et al. 2016

Turkish Neurosurgery

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AIm: Cerebral vasospasm after subarachnoid hemorrhage (SAH) may lead to a devastating neurological outcome by inducing cerebral ischemia. However the role of external carotid artery (ECA) vasospasm has been rarely reported in the literature. The aim of this study was to elucidate the effect of ECA vasospasm on cerebral ischemia related neurodegeneration in the cerebral cortex after SAH. mATERIAl and mEThODS:This study was performed on 23 rabbits, divided into three groups: control (n=5), sham (n=5), and SAH (n=13). Experimental SAH was performed by injecting 0.75 mL auricular arterial homologous blood into the cisterna magna. After three weeks, the animals were decapitated and the common carotid arteries with their external and internal branches and the brains were examined histopathologically. Vasospasm indexes (VSI) of ECAs and internal carotid arteries (ICAs) and degenerated glial cell numbers of temporal cortices (n/mm 3 ) were estimated stereologically and the results were compared statistically. CONClUSION: ECA vasospasm was observed to have a more important predictive role on the serious cerebral ischemia and neuronal degeneration after SAH. The mechanism may be related to ischemia of the parasympathetic ganglia of the lower cranial nerves and dorsal root ganglion. RESUlTS

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“…It causes extracranial complications besides intracranial complications (1,11, 25,52). One of the most common physical signs seen in SAH patients is the abnormalities of pupil diameters.…”

Section: █ Introductionmentioning

confidence: 99%

Uncovering of the forgotten effect of superior cervical ganglia on pupil diameter determination in subarachnoid hemorrhage: experimental study

Önen

Yılmaz²,

Ramazanoglu³

et al. 2016

Turkish Neurosurgery

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AIm: To investigate the relationship between neuron density of the superior cervical sympathetic ganglia and pupil diameter in subarachnoid hemorrhage. mATERIAl and mEThODS:This study was conducted on 22 rabbits; 5 for the baseline control group, 5 for the SHAM group and 12 for the study group. Pupil diameters were measured via sunlight and ocular tomography on day 1 as the control values. Pupil diameters were re-measured after injecting 0.5 cc saline to the SHAM group, and autologous arterial blood into the cisterna magna of the study group. After 3 weeks, the brain, superior cervical sympathetic ganglia and ciliary ganglia were extracted with peripheral tissues bilaterally and examined histopathologically. Pupil diameters were compared with neuron densities of the sympathetic ganglia and ciliary ganglia which were examined using stereological methods. RESulTS:Baseline values were; normal pupil diameter 7.180±620 µm and mean neuron density of the superior cervical sympathetic ganglia 6.321±510/mm 3 , degenerated neuron density of ciliary ganglia was 5±2/mm 3 after histopathological examination in the control group. These values were measured as 6.850±578 µm, 5.950±340/mm 3 and 123±39/mm 3 in the SHAM group and 9.910±840 µm, 7.950±764/mm 3 and 650±98/mm 3 in the study group. A linear relationship was determined between neuron density of the superior cervical sympathetic ganglia and pupil diameters (p<0.005). Degenerated ciliary ganglia neuron density had an inverse effect on pupil diameters in all groups (p<0.0001). CONCluSION:Highly degenerated neuron density of the ciliary ganglion is not responsible for pupil dilatation owing to parasympathetic pupilloconstrictor palsy, but high neuron density of the pupillodilatatory superior cervical sympathetic ganglia should be considered an important factor for pupil dilatation.

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Role of neuron density of the stellate ganglion on regulation of the basilar artery volume in subarachnoid hemorrhage: An experimental study

Cited by 28 publications

References 20 publications

How Reliable Is Pupillary Evaluation Following Subarachnoid Hemorrhage? Effect of Oculomotor Nerve Degeneration Secondary to Posterior Communicating Artery Vasospasm: First Experimental Study

How Reliable Is Pupillary Evaluation Following Subarachnoid Hemorrhage? Effect of Oculomotor Nerve Degeneration Secondary to Posterior Communicating Artery Vasospasm: First Experimental Study

Predictive role of external carotid artery vasospasm on cerebral ischemia in subarachnoid hemorrhage: experimental study

Uncovering of the forgotten effect of superior cervical ganglia on pupil diameter determination in subarachnoid hemorrhage: experimental study

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