Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.

Global Urinary Volatolomics with (GC×)GC-TOF-MS

“…While the addition of HCl might compromise the recovery of basic compounds, short chain fatty acid imbalances have been associated with numerous health conditions and particularly with pancreatic ductal adenocarcinoma . The effect of HCl addition and extraction under similar conditions has been studied extensively in our previously published work.…”

“…While the addition of HCl might compromise the recovery of basic compounds, short chain fatty acid imbalances have been associated with numerous health conditions and particularly with pancreatic ductal adenocarcinoma. 10 The effect of HCl addition and extraction under similar conditions has been studied extensively in our previously published work. We showed there that multiple VOC categories of key chemical classes were benefited by extraction under the same conditions with the present study and that there was no evidence of artifact formation.…”