Role of Maternal Serum Glycodelin as Predictor of Ectopic Pregnancy in First Trimester

Ibrahim, Wasan Wajdi; Al-Naddawi, Afraa Mahjoob; Fawzi, Hayder Adnan

doi:10.15296/ijwhr.2019.77

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…However, this explanation is now deemed untenable. The occurrence of vasodilatation during spontaneous migraine attacks, if present, is likely to be an epiphenomenon that arises from instability in the central neurovascular control mechanism (12)(13)(14)(15).…”

Section: Hamzah and Kassabmentioning

confidence: 99%

Frovatriptan succinate intranasal delivery for brain targeting – in vivo study.‎

Hamzah,

Kassab

2023

Iraqi J. Vet. Med.

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Muco-adhesive gel formulations are advantageous in extending the stay at the nasal ‎absorption place, promoting drug absorption. Frovatriptan succinate (FVT) exhibits a 35% ‎oral bioavailability and undergoes hepatic metabolism, making it a viable candidate for ‎nasal delivery. This study aimed to assess novel FVT intranasal formulation for brain ‎targeting in rat animal models. A total of 78 female rats (Rattus norvegicus domestica, ‎Wister albino rats) were randomly divided into three groups: group A (considered a ‎negative control), group B (includes 36 rats given FVT IV solution), and group C (includes ‎‎36 rats given FVT binary ethosome in situ gel intranasally). Drug levels in plasma and brain ‎tissue were measured using HPLC methods. In all periods, for both brain tissue ‎concentrations of FVT and the brain-to-plasma ratio of FVT, it was significantly higher in ‎Group C compared to Group B. Nasal administration of FVT showed higher brain Tmax, ‎Cmac, and AUC compared to IV administration, with 239.83% higher accumulation of FVT ‎when nasal formulation used compared to IV administration. In conclusion, in situ gel has ‎demonstrated its efficacy in facilitating the delivery of frovatriptan succinate via the nasal ‎route. The convenience of the administration process, combined with reduced frequency of ‎administration, contributes to improved patient adherence‎‎‎.

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Section: Hamzah and Kassabmentioning

confidence: 99%

Frovatriptan succinate intranasal delivery for brain targeting – in vivo study.‎

Hamzah,

Kassab

2023

Iraqi J. Vet. Med.

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The evaluation of maternal serum glycodelin level as a marker for the presence and severity of preeclampsia

Fawzi,

Rifat

2023

MJBL

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Background: Preeclampsia (PE) is a common multisystemic disorder of pregnancy. Glycodelin is a glycoprotein belongs to the lipocalin superfamily. It acts as a regulator of immunosuppression activity, fertilization, implantation, and placentation. Objectives: To analyze serum glycodelin levels in PE and evaluate whether it correlates with the severity of the disease. Materials and Methods: A prospective case–control study included 60 women diagnosed with PE (subdivided into 30 pregnant women with mild PE and 30 pregnant women with severe PE) and 30 healthy normotensive pregnant women. Patient with multiple pregnancies, gestational trophoblastic diseases, in active labor, a history of medical diseases, or taking treatment were excluded from the study. Blood samples were taken for biochemical study; serum glycodelin levels were measured using an enzyme-linked immunosorbent assay. Results: Patients with PE had significantly higher mean glycodelin levels as compared to the normal group. The glycodelin level ≥37.9 ng/mL had 96.70% sensitivity, 100% specificity, and 98% accuracy for the prediction of PE. The mean glycodelin was significantly higher in severe PE (102.3 ± 51.3) as compared to mild PE (45.2 ± 7.3) in pregnant women (P < 0.001). The glycodelin level ≥50.1 ng/mL had 86.7% sensitivity, 80% specificity, and 85% accuracy for the prediction of severe PE. Conclusions: Glycodelin is an appropriate marker for the diagnosis of PE and the categorization of disease according to severity.

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Role of Maternal Serum Glycodelin as Predictor of Ectopic Pregnancy in First Trimester

Cited by 2 publications

References 11 publications

Frovatriptan succinate intranasal delivery for brain targeting – in vivo study.‎

Frovatriptan succinate intranasal delivery for brain targeting – in vivo study.‎

The evaluation of maternal serum glycodelin level as a marker for the presence and severity of preeclampsia

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