Role of Liposomes-Based Stem Cell for Multimodal Cancer Therapy

Mandpe, Pankaj; Prabhakar, Bala; Shende, Pravin

doi:10.1007/s12015-019-09933-z

Cited by 15 publications

(6 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because their phospholipids are close to the components of cell membranes, they are extremely suitable for drug delivery. 26 The liposome is divided into a hydrophilic shell Notes: Data were presented as mean±SD. *Significantly different from the BA group at P < 0.05, **Extremely significant different from the I/R group at P < 0.01.…”

Section: Discussionmentioning

confidence: 99%

<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>

Zhang¹,

Liu²,

Wan³

et al. 2020

IJN

View full text Add to dashboard Cite

Baicalin (BA) has a good neuroprotective effect, but it is eliminated quickly in the body and does not easily reach the brain. In this experiment, borneol (BO) was used as an auxiliary drug to prepare borneol-baicalin-liposomes (BO-BA-LP) to prolong the efficacy time of BA, synergistically synergize, introduce drugs into the brain, and better exert the therapeutic effect on cerebral ischemia-reperfusion (I/R) injury. Methods: Through single-factor inspection and response surface optimization analysis, obtained the best preparation process of BO-BA-LP and characterized by various analytical techniques. Validated the long-term effectiveness of BA-BO-LP through pharmacokinetic studies and conducted pharmacodynamic studies on the middle cerebral artery occlusion (MCAO) rat model to verify the therapeutic effect of BO-BA-LP on cerebral I/R injury. Results: The optimum preparation conditions of BO-BA-LP were as follows: the dosage of BO was 9.55 mg, the ratio of phospholipid to drug was 4.02:1, the ratio of phospholipid to cholesterol was 7.25:1, the entrapment efficiency (EE) was 41.49%, and the drug loading (DL) was 4.29%. The particle size range of the liposomes was 167.1 nm, and the polydispersity index (PDI) range was 0.113. The results of pharmacokinetic experiments showed that the combination of BA and BO liposomes effectively improved the pharmacokinetic parameters of BA and prolonged the half-life of BA. Pharmacodynamic studies have found that, compared with BA-LP, BO-BA-LP can significantly improve neurological deficits, cerebral infarction volume, and brain pathological states on MCAO rats. Conclusion: These results demonstrated that BO-BA-LP can improve the circulation of drugs in the blood, and the addition of BO can enhance the therapeutic effect of BA and effectively improve cerebral I/R.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>

Zhang¹,

Liu²,

Wan³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…222,223 Preparation of aspirincontaining liposomes by a thin film dispersion method and integration into DOPA3d printed PCL scaffold 238 bisphosphate-encapsulated liposomes in rats exhibited a strong binding effect, which increased drug retention. 240 Long-circulating polyethylene glycolyzed poly (tritiated ester) liposomes induce CSCs apoptosis in mice and are effective therapeutic agents for further inhibition of CSCs growth. 241 Cross-linked multilayer liposomes composed of adriamycin (Dox) and salicin (Sal) interact with breast cancer tumor cells as well as CSCs and effectively inhibit the cancer cells.…”

Section: Liposomes and Nanoliposomesmentioning

confidence: 99%

Application of stem cells in regeneration medicine

Jin

et al. 2023

MedComm

View full text Add to dashboard Cite

Regeneration is a complex process affected by many elements independent or combined, including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive cells with the potentiality of differentiation, regenerate with self‐replication, multidirectional differentiation, and immunomodulatory functions. Stem cells and their cytokines not only inextricably linked to the regeneration of ectodermal and skin tissues, but also can be used for the treatment of a variety of chronic wounds. Stem cells can produce exosomes in a paracrine manner. Stem cell exosomes play an important role in tissue regeneration, repair, and accelerated wound healing, the biological properties of which are similar with stem cells, while stem cell exosomes are safer and more effective. Skin and bone tissues are critical organs in the body, which are essential for sustaining life activities. The weak repairing ability leads a pronounced impact on the quality of life of patients, which could be alleviated by stem cell exosomes treatment. However, there are obstacles that stem cells and stem cells exosomes trough skin for improved bioavailability. This paper summarizes the applications and mechanisms of stem cells and stem cells exosomes for skin and bone healing. We also propose new ways of utilizing stem cells and their exosomes through different nanoformulations, liposomes and nanoliposomes, polymer micelles, microspheres, hydrogels, and scaffold microneedles, to improve their use in tissue healing and regeneration.

show abstract

“…Al-Attar and collaborators evaluated a combination of drug delivery devices composed of holo-transferrin conjugated liposomes for siRNA (targeting BCR-ABL) delivery, and electrospun polycaprolactone-gelatin microfibers for resveratrol release [215]. For additional applications on liposomes for gene therapy see [50,209,[216][217][218][219].…”

Section: Lipid Basedmentioning

confidence: 99%

Gene Therapy in Cancer Treatment: Why Go Nano?

et al. 2020

View full text Add to dashboard Cite

The proposal of gene therapy to tackle cancer development has been instrumental for the development of novel approaches and strategies to fight this disease, but the efficacy of the proposed strategies has still fallen short of delivering the full potential of gene therapy in the clinic. Despite the plethora of gene modulation approaches, e.g., gene silencing, antisense therapy, RNA interference, gene and genome editing, finding a way to efficiently deliver these effectors to the desired cell and tissue has been a challenge. Nanomedicine has put forward several innovative platforms to overcome this obstacle. Most of these platforms rely on the application of nanoscale structures, with particular focus on nanoparticles. Herein, we review the current trends on the use of nanoparticles designed for cancer gene therapy, including inorganic, organic, or biological (e.g., exosomes) variants, in clinical development and their progress towards clinical applications.

show abstract

Role of Liposomes-Based Stem Cell for Multimodal Cancer Therapy

Cited by 15 publications

References 82 publications

<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>

<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>

Application of stem cells in regeneration medicine

Gene Therapy in Cancer Treatment: Why Go Nano?

Contact Info

Product

Resources

About