2014
DOI: 10.1155/2014/987303
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Role of Lipid Peroxidation Products, Plasma Total Antioxidant Status, and Cu-, Zn-Superoxide Dismutase Activity as Biomarkers of Oxidative Stress in Elderly Prediabetics

Abstract: The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation. Methods. 52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure. During an oral glucose tolerance test (OGTT) fasting (0′) and 120-minute (120′) … Show more

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Cited by 23 publications
(18 citation statements)
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“…Our previous study showed a significant positive correlation between SOD -1 and TAS in normoglycemic patients, while no such correlation was observed in hyperglycemic ones. 30 In this study, we found a similar strong positive correlation between SOD -1 and TAS in the high HDL -C group, whereas in the low HDL -C group, a disintegration between intra-and extracellular antioxidant state was observed. In the low HDL -C group, a positive correlation between TAS and Tg levels might reflect the mobilizing effect of Tg on plasma antioxidant capacity associated with a decrease in HDL -C levels.…”
Section: Resultssupporting
confidence: 72%
“…Our previous study showed a significant positive correlation between SOD -1 and TAS in normoglycemic patients, while no such correlation was observed in hyperglycemic ones. 30 In this study, we found a similar strong positive correlation between SOD -1 and TAS in the high HDL -C group, whereas in the low HDL -C group, a disintegration between intra-and extracellular antioxidant state was observed. In the low HDL -C group, a positive correlation between TAS and Tg levels might reflect the mobilizing effect of Tg on plasma antioxidant capacity associated with a decrease in HDL -C levels.…”
Section: Resultssupporting
confidence: 72%
“…The negative correlation between age and thiol levels, and the positive correlation between disulfide forms determined in our study shows that oxidative stress levels increase with age [18,23,26,27].…”
Section: Discussionsupporting
confidence: 58%
“…Many previous studies have shown that oxidative stress levels increase in prediabetic patients [12,13]. These have been associated with the increase of oxidant radicals [13] or the decrease of antioxidant capacity [18]. There are a limited number of studies showing the thiol/disulfide homeostatic status in prediabetic patients [12].…”
Section: Discussionmentioning
confidence: 99%
“…It is observed that greater SOD activity in newly detected type 2 diabetic patients than normal glucose tolerance patients (Siddiqui et al, 2019). It is also reported that decreased erythrocytic superoxide dismutase activity in elderly prediabetic patients (Dzięgielewska-Gęsiak et al, 2014). The increase in the total SOD activity suggests an adaptive reaction, maybe due to the increased generation of superoxide anion radical, which would lead to an increase in the formation of H2O2 (Bandeira et al, 2012).…”
Section: Discussionmentioning
confidence: 95%