Role of kisspeptin in polycystic ovary syndrome (PCOS)

Özay, Özlen Emekçi; Özay, Ali Cenk; Acar, Berrin; Çağlıyan, Erkan; Seçil, Mustafa; Küme, Tuncay

doi:10.3109/09513590.2016.1161019

Cited by 47 publications

(38 citation statements)

References 21 publications

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“…The present results are in agreement with previous studies of Chen et al [ 17 ], Jeon et al [ 18 ], and Yilmaz et al [ 19 ], who reported elevated mean serum kisspeptin levels in PCOS women and Ozay et al [ 20 ] who reported the positive correlations between kisspeptin, LH and leptin levels in PCOS patients. None of the previous studies took in consideration the clinical aspect of the intermenstrual intervals of their PCOS patients.…”

Section: Discussionsupporting

confidence: 94%

Kisspeptin and LH pulsatile temporal coupling in PCOS patients

et al. 2018

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PurposeTo evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients.MethodsWe examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), cortisol, 17-hydroksy-progesterone (17OHP), testosterone (T), free testosterone index (FTI, and insulin levels were also measured. Detect and Specific Concordance (SC) algorithms were used to evaluate the temporal coupling associations between spontaneous episodic secretion of kisspeptin and LH.ResultsAll PCOS patients demonstrated LH and kisspeptin pulsatile secretions. When the SC index was calculated across the sample of PCOS patients (n = 71), no temporal coupling was observed between kisspeptin and LH pulses. When PCOS patients were subdivided according to their menstrual cyclicity, oligomenorrheic patients demonstrated elevated kisspeptin pulse frequency. Additionally, the SC index reveled a temporal coupling between kisspeptin and LH secretory peaks only in eumenorrheic patients (n = 30, intermenstrual interval < 45 days). Oligomenorrheic PCOS patients (intermenstrual interval > 45 days) did not demonstrate temporal coupling between kisspeptin and LH secretory peaks.ConclusionsThe study of the endogenous kisspeptin and LH pulsatile release revealed the temporal coupling of kisspeptin with LH secretory pulses only in eumenorrheic. This data supports the hypothesis that neuroendocrine impairments in PCOS affect the coupling of kisspeptin with LH pulses and potentially worsen as the disease progresses, becoming unequivocally evident in oligomenorrheic PCOS patients.

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Section: Discussionsupporting

confidence: 94%

Kisspeptin and LH pulsatile temporal coupling in PCOS patients

et al. 2018

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“…[34] Furthermore, a prospective study by Ozay et al . [35] carried out in a larger group did not find any difference between kisspeptin levels of PCOS group and controls.…”

Section: Discussionmentioning

confidence: 85%

Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study

Umayal

Jayakody

Chandrasekharan

et al. 2019

Journal of Postgraduate Medicine

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“…In mice, KISS1 has been identified as one of the differentially expressed genes of ESR2-mutant young adult females with the failure of follicular maturation [37]. In humans, compared to the normal women, the infertile women with polycystic ovary syndrome have increased serum kisspeptin levels [38], and serum kisspeptin has a positive correlation with the serum levels of LH and leptin [39]. These observations suggest that ovarian KISS1 may play a critical role in regulating the follicle maturation.…”

Section: Discussionmentioning

confidence: 99%

KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells

Xin

Zhong

et al. 2019

Animals

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Previous studies have strongly recommended that KISS-1 metastasis suppressor (KISS1) plays an essential gatekeeper of the initiation of reproductive maturation in mammals. However, KISS1 has been recently reported to highly express in ovarian granulosa cells (GCs). But the biological functionalities of KISS1 on cell apoptosis, cell cycle, and synthesis of estradiol-17β (E2) have not been explored in GCs. In this study, using porcine GCs as a cellular model, the overexpression plasmid of KISS1 was built to explore the biological effects of KISS1 on the PI3K signaling pathway, estrogen signaling pathway, cell apoptosis, cell cycle, and E2 secretion. We found that mRNA of KISS1 highly expressed in the ovary and significantly increased from immature to mature follicles in gilts. Overexpression of KISS1 could significantly increase the mRNA expression of PIK3CG, PIK3C1, and PDK1, and significantly decreased the mRNA levels of FOXO3, TSC2, and BAD of PI3K signaling pathway. Furthermore, results of the flow cytometry showed that overexpression of KISS1 significantly inhibited the apoptosis of GCs and decreased the percentage of GCs at G0/G1 phase of the cell cycle. Additionally, overexpression of KISS1 could increase the mRNA levels of Star, CYP17, 3B-HSD, 17B-HSD of estrogen synthesis signaling pathway, significantly increase the concentration of E2 in the supernatant of the cultured GCs, and up-regulate the mRNA expression levels of ESR1 and ESR2. These results suggested that KISS1 might suppress cell apoptosis through activating the PI3K signaling pathway and stimulate synthesis of E2 via boosting the estrogen synthesis signaling pathway. This study would be of great interests for exploring the biological functionalities of KISS1 in the folliculogenesis and sex steroid production of the ovaries in mammals.

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Role of kisspeptin in polycystic ovary syndrome (PCOS)

Cited by 47 publications

References 21 publications

Kisspeptin and LH pulsatile temporal coupling in PCOS patients

Kisspeptin and LH pulsatile temporal coupling in PCOS patients

Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study

KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells

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