Role of iron in cancer development by viruses

Shoja, Zabihollah; Chenari, Maryam; Jafarpour, Ali; Jalilvand, Somayeh

doi:10.1002/rmv.2045

Cited by 5 publications

(2 citation statements)

References 149 publications

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“…Ferroptosis is a newly found programmed cell death that relies on iron ion that can promote lipid peroxidation, which is different with apoptosis or necrosis [ 17 ]. The former researches have explored that it is common that high levels of iron are related in a variety of cancer cells rather than in normal cells [ 49 – 53 ]. Moreover, cell death, especially ferroptosis, is critical for glioma development, and it affects pathological classification and sensitivity to chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma

Lin¹,

Zhu³

et al. 2023

Cell Biochem Biophys

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Ferroptosis is a newfound mode of regulated cell death that may have potential to associate with prognostic or diagnostic factors in glioma. In this research, 5 genes related to glioma were screened through the FerrDb database, and we analyzed the combination between genes and glioma of survival and prognosis via TCGA, GEPIA, TIMER, and other databases. Survival curve and prognostic analysis showed that the overexpression of NFE2L2 and NOX4, respectively, has a remarkable link with a worse prognosis in glioma. Then, the association between the expression of the two genes and tumor-infiltrating immune cells level was explored based on the GSCA, and the immunity of NFE2L2 and NOX4 based on the TISIDB database was also investigated. In glioma, especially GBM, there is a strong association between gene expression and immune infiltration, even in macrophages, nTreg, and Th2 cells, which play immunosuppressive functions in TME. In conclusion, these results indicate that NFE2L2 and NOX4 could be risk prognosis biomarkers in glioma, and they bound up with immune infiltration and tumor immunity in tumorigenesis.

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Section: Discussionmentioning

confidence: 99%

Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma

Lin¹,

Zhu³

et al. 2023

Cell Biochem Biophys

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“…Cells undergoing ferroptosis gain a round shape before death with its distinctive feature, the smaller mitochondria, and increased mitochondrial membrane density. Previously, many pieces of researches have revealed that cancer cells in several cancers e.g., ovarian, lung, and breast cancers have high levels of iron relative to normal cells [ 40 – 45 ]. Moreover, it is reported that salinomycin can kill cancer stem cells by sequestering iron in lysosomes causing lysosomal membrane permeabilization and ferroptosis, suggesting that therapies targeting ferroptosis might be a possible strategy for cancer [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma

Zhu

Zhou

et al. 2021

Aging

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Background: Glioblastoma (GBM) is the most common type of brain cancer with poor survival outcomes and unsatisfactory response to current therapeutic strategies. Recent studies have demonstrated that ferroptosis-related genes (FRGs) are linked with the occurrence and development of GBM and may become promising biological indicators in GBM therapy. Methods: We systematically assessed the relationship between FRGs expression profiles and prognosis in glioma patients based on the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) datasets to establish a risk score model according to the gene signature of multiple survival-associated DEGs. Further, the differences between the tumor microenvironment score, immune cell infiltration, immune checkpoint expression levels, and drug sensitivity in the high- and low-risk group are analyzed through a variety of algorithms in R software. Results: GBM patients were divided into two subgroups (high- and low-risk) according to the established risk score model. Patients in the high-risk group showed significantly reduced overall survival compared with those in the low-risk group. Also, we found that the high-risk group showed higher ImmuneScore and StromalScore, while different subgroups have significant differences in immune cell infiltration, immune checkpoint expression levels, and drug sensitivity. In summary, we developed and validated an FRGs risk model, which served as an independent prognostic indicator for GBM. Besides, the two subgroups divided by the model have significant differences, which provides novel insights for further studies as well as the personalized treatment of patients.

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ROS‐Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide‐Containing Recombinant Apoferritin

Huang

Yuan

et al. 2019

Adv Healthcare Materials

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Reactive oxygen species (ROS)‐mediated apoptosis is considered a crucial therapeutic mechanisms for artesunate (AS). As an Fe(II)‐dependent drug, the anticancer effect of AS is often limited due to insufficient Fe(II) concentration in targeted cells. To overcome this problem, a recombinant apoferritin nanocarrier containing ferriferous oxide (M‐HFn) is constructed to produce auxiliary exogenous Fe(II) when delivering AS to cancer cells. Here, the newly fabricated AS‐loaded M‐HFn nanoparticles (M‐HFn@AS NPs) can significantly improve the tumor‐specific targeting and intracellular uptake efficiency of AS in human cervical carcinoma cells. After being captured in the acidic cavity of endosomes, M‐HFn@AS NPs can simultaneously release Fe(II) and allow AS to activate satisfactory ROS‐mediated apoptosis. Furthermore, in vivo studies demonstrate that M‐HFn@AS NPs can selectively accumulate in tumors to efficiently inhibit tumor growth. Thus, M‐HFn@AS NPs are a promising system to enhance the therapeutic effect of Fe(II)‐dependent drugs.

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Role of iron in cancer development by viruses

Cited by 5 publications

References 149 publications

Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma

Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma

Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma

ROS‐Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide‐Containing Recombinant Apoferritin

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