ROS‐Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide‐Containing Recombinant Apoferritin

Ji, Peng; Huang, Haiqin; Yuan, Shirui; Wang, Le; Wang, Siqi; Chen, Yiwei; Feng, Na; Veroniaina, Hanitrarimalala; Wu, Ziheng; Wu, Zhenghong; Qi, Xiaole

doi:10.1002/adhm.201900911

Cited by 46 publications

(38 citation statements)

References 57 publications

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“…In recent years, artemisinin and its derivatives (e.g., dihydroartemisinin and artesunate) have been recognized as effective antimalarial agents [119]. They also have anticancer and anti-angiogenic properties with cytotoxic effects against several cancer types in vitro and in vivo [120][121][122]. Dihydroartemisinin inhibited the proliferation of HeLa and Caski cells in a dose-and time-dependent manner with IC 50 values of 22.08 and 18.20 µmol/L, respectively.…”

Section: Sesquiterpenoidsmentioning

confidence: 99%

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

2021

Biomolecules

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Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects.

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Section: Sesquiterpenoidsmentioning

confidence: 99%

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

2021

Biomolecules

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“…Direct conjugation of ARTs to transferrin may lead to some drawbacks such as limited loading efficiency and potential suppressive effect to the intrinsic biological functions of transferrin. To overcome the drawbacks, some much advanced nanosystems have been presented (Zhang et al, 2015a,b;Ji et al, 2019;Luo et al, 2019). For example, in a recent study, Xing's group reported a system for pH-triggered cancer chemotherapy by coating graphene oxide (GO) with both transferrin and DHA, where transferrin served as not only a cancer cell-targeting ligand but also an iron carrier (Liu et al, 2015).…”

Section: Iron-containing Soft Matters For Arts Delivery and Activationmentioning

confidence: 99%

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Zeng

et al. 2020

Front. Chem.

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Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect. To solve the issues regarding poor solubility and limited bioavailability of ARTs, nanoformulation of ARTs has thus emerged as a promising strategy for cancer treatment. A common consideration on nanoARTs design lies on ARTs' delivery and controlled release, where ARTs are commonly regarded as hydrophobic drugs. Based on the mechanism that ARTs' activation relies on ferrous ions (Fe 2+ ) or Fe 2+ -bonded complexes, new designs to enhance ARTs' activation have thus attracted great interests for advanced cancer nanotherapy. Among these developments, the design of a nanoparticle that can accelerate ARTs' activation has become the major consideration, where ARTs have been regarded as radical precursors. This review mainly focused on the most recent developments of ARTs nanotherapeutics on the basis of advanced drug activation. The basic principles in those designs will be summarized, and a few excellent cases will be also discussed in detail.

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“…ROS can function as an important signaling molecule, mediating a myriad of bioactivities, on the other hand, ROS could interact with pivotal cellular targets, including lipid, protein and DNA, leading to serious damage to cellular homeostasis [21]. Various researches demonstrated that ROS could facilitate the anti-neoplastic effect of numerous chemicals, including sodium butyrate [22], artesunate [23], ginsenoside, and so on [24]. Nevertheless, the way TQ regulates the level of intracellular ROS varies among different tissue and cell types [13], and whether TQ can exert its anti-cancer effect via regulating the level of ROS is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

Zhou¹,

Wang²,

Wu³

et al. 2021

Int. J. Biol. Sci.

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Bladder carcinoma is among the top 10 most frequently diagnosed cancer types in the world. As a phytochemical active metabolic, thymoquinone (TQ) is extracted from seeds of Nigella sativa, possessing various biological properties in a wide range of diseases. Moreover, the outstanding anti-cancer effect of TQ is attracting increasing attentions. In certain circumstances, moderate autophagy is regarded to facilitate the adaptation of malignant cells to different stressors. Conversely, closely linked with the mitochondrial membrane potential (MMP) loss, the upregulation of intracellular reactive oxygen species (ROS) is reported to activate the cell apoptosis in many cancer types. Furthermore, the vital effects of microRNAs in the pathological processes of cancer cells have also been confirmed by previous studies. The present research confirms that TQ restrains the viability, proliferation, migration and invasion through activating caspase-dependent apoptosis in bladder carcinoma cells, which is mediated by TQ induced ROS increase in bladder carcinoma cells. Furthermore, TQ is proved to block the fusion of autophagosomes and lysosomes, causing the accumulation of autophagosomes and subsequent cell apoptosis. In addition, TQ is also found to initiate the miR-877-5p/PD-L1 axis, which suppresses the epithelial mesenchymal transition (EMT) and invasion of bladder carcinoma cells. Taken together, TQ induces the apoptosis through upregulating ROS level and impairing autophagic flux, and inhibiting the EMT and cell invasion via activating the miR-877-5p/PD-L1 axis in bladder carcinoma cells.

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ROS‐Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide‐Containing Recombinant Apoferritin

Cited by 46 publications

References 57 publications

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

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