Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

He, Meizhu; Li, Xia; Li, Jinyao

doi:10.3390/biom11101539

Cited by 20 publications

(13 citation statements)

References 183 publications

(180 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excess free radicals were removed in certain doses. Puerarin as reported improved the tissue damage induced via ROS, then increased the ability to fight tumors (He et al, 2021).…”

Section: Flavoniodsmentioning

confidence: 94%

Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways

Zhou

Long

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Inflammation is a protective response of the body to an irritant. When an inflammatory response occurs, immune cells are recruited to the injury, eliminating the irritation. The excessive inflammatory response can cause harm to the organism. Inflammation has been found to contribute to cervical cancer if there is a problem with the regulation of inflammatory response. Cervical cancer is one of the most common malignant tumors globally, and the incidence tends to be younger. The harm of cervical cancer cannot be ignored. The standard treatments for cervical cancer include surgery, radiotherapy and chemotherapy. However, the prognosis for this treatment is poor, so it is urgent to find a safer and more effective treatment. Natural products are considered excellent candidates for the treatment of cervical cancer. In this review, we first describe the mechanisms by which inflammation induces cervical cancer. Subsequently, we highlight natural products that can treat cervical cancer through inflammatory pathways. We also introduce natural products for the treatment of cervical cancer in clinical trials. Finally, methods to improve the anticancer properties of natural products were added, and the development status of natural products was discussed.

show abstract

“…Excess free radicals were removed in certain doses. Puerarin as reported improved the tissue damage induced via ROS, then increased the ability to fight tumors (He et al, 2021).…”

Section: Flavoniodsmentioning

confidence: 94%

Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways

Zhou

Long

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Methyl jasmonate treatment significantly increased the total anthocyanin and phenol contents in blackberry fruits; inhibited cell proliferation in human lungs, A549 cells, and HL-60 leukemia cells; and induced the apoptosis of HL-60 cells [ 21 ]. Cyanidin 3-O-glucoside (C3G) may increase cisplatin’s antitumor activity to reduce the adverse effects of chemotherapy in cervical cancer [ 22 ]. Several mechanisms have been proposed to mediate the anticancer properties of anthocyanins.…”

Section: Introductionmentioning

confidence: 99%

Research on Anthocyanins from Rubus “Shuofeng” as Potential Antiproliferative and Apoptosis-Inducing Agents

Zhao

Wang

et al. 2023

Foods

View full text Add to dashboard Cite

Blackberries have high nutritional value and strong biological activities, such as antiproliferative activity. Anthocyanins are important functional components in blackberries. We collected 25 kinds (lines) of blackberries from our nursery to investigate antiproliferative agents in natural foods. Among them, the Shuofeng variety had the highest anthocyanin content, with 2.54 mg/g of fresh fruit, which increased to 357.75 mg/g of dried powder through ultrasound-assisted solvent extraction and macroporous resin adsorption. Additional experiments showed that Shuofeng’s anthocyanin content had high anti-HepG2 activity in vitro and in vivo, as well as activity against Hela (68.62 μg/mL), HepG2 (55.85 μg/mL), MCF-7 (181.21 μg/mL), and A549 cells (82.01 μg/mL), as determined by MTT assay. It also had no apparent toxic effects. The combination of DDP and DOX significantly enhanced the antiproliferative activity of the four cell lines. The IC50 value of Shuofeng’s anthocyanin content combined with DOX in HepG2 cells was the lowest at only 0.08 μg/mL, indicating that the combination of drugs had additive and synergistic effects. Shuofeng’s anthocyanin content might intercalate into DNA and alter or destroy DNA, causing apoptosis and inhibiting cell proliferation. Our results show that blackberry anthocyanins can inhibit the proliferation of cancer cells and their possible mechanisms. However, we must study the deeper mechanism and explore its targeting effects in the future.

show abstract

“…Several compounds derived from natural products, such as Genistein, Puerarin, Formononetin, Cyanidin Anthocyanins, Curcumin, Emodin, Epifriedelanol, Mitomycin C, and Piperine, induce apoptosis in cervical cancers [6,43]. Activation of apoptosis is used as an anticancer mechanism in cancer therapy research [6].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Cytotoxic and Apoptosis Induction Potential of Two Plant Extracts on HeLa Cells

Ozsoylemez¹,

Özcan²

2023

Cytotoxicity - Understanding Cellular Damage and Response

View full text Add to dashboard Cite

Natural products are commonly used for developing anticancer drugs that are beneficial for various cancer types. The aim of this study is to apply Colchicum umbrosum Steven and Colchicum baytopiorum CD Brickell (one of the endemic species in Turkey) extracts on HeLa cell lines and determine changes in cytotoxicity and viability. For this aim, kinetic parameters such as proliferation rate have been determined by MTT assay, and apoptotic index (AI) has been researched by fluorescence microscopies using DAPI staining. Also, some apoptosis-related genes have been examined by the RT-PCR method. Five different concentrations of both extracts from the two Colchicum species have cytotoxic effects and it has been understood that HeLa cells were more sensitive to the most effective concentration of the C. baytopiorum extract, which is 0.1 mg/ml, and it showed antitumor effects by causing apoptosis for 48 h. The cytotoxic activity and apoptotic effects of Colchicum umbrosum Steven and Colchicum baytopiorum (Colchicaceae/Liliaceae) have been studied for the first time on HeLa cell lines. We suggested that the medicines derived from natural products seem to be a new promising treatment for cancer.

show abstract

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

Cited by 20 publications

References 183 publications

Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways

Therapeutic Effects of Natural Products on Cervical Cancer: Based on Inflammatory Pathways

Research on Anthocyanins from Rubus “Shuofeng” as Potential Antiproliferative and Apoptosis-Inducing Agents

In Vitro Cytotoxic and Apoptosis Induction Potential of Two Plant Extracts on HeLa Cells

Contact Info

Product

Resources

About