Role of interleukin‐6 and pentraxin 3 as an early marker in Peyronie's disease

Atar, Arda; Kural, Alev; Yenice, Gurkan; Comez, Ilker; Tuğcu, Volkan

doi:10.1016/j.kjms.2017.01.007

Cited by 12 publications

(13 citation statements)

References 31 publications

(37 reference statements)

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“…Here, our data suggest that PPARγ, whose activity has been shown to be modulated by lipid ingestion (den Besten et al., 2015), could stimulate IL-6 expression through the activation of other proteins. In turn, IL-6 can induce the production of other pro-inflammatory proteins like PTX3 (Figure 6; Atar et al., 2017). Co-incidence of elevated IL-6 and lower GSH levels was previously reported (Valles et al., 2013), while obesogenic diets were shown to induce both of these effects in mice (Han et al., 2017) and rats (Govindaraj and Sorimuthu Pillai, 2015).…”

Section: Discussionmentioning

confidence: 99%

A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats

et al. 2019

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Obesity and ensuing disorders are increasingly prevalent worldwide. High-fat diets (HFD) and diet-induced obesity have been shown to induce oxidative stress and inflammation while altering metabolic homeostasis in many organs, including the skeletal muscle. We previously observed that 14 days of HFD impairs contractile functions of the soleus (SOL) oxidative skeletal muscle. However, the mechanisms underlying these effects are not clarified. In order to determine the effects of a short-term HFD on skeletal muscle glutathione metabolism, young male Wistar rats (100–125 g) were fed HFD or a regular chow diet (RCD) for 14 days. Reduced (GSH) and disulfide (GSSG) glutathione levels were measured in the SOL. The expression of genes involved in the regulation of glutathione metabolism, oxidative stress, antioxidant defense and inflammation were measured by RNA-Seq. We observed a significant 25% decrease of GSH levels in the SOL muscle. Levels of GSSG and the GSH:GSSG ratio were similar in both groups. Further, we observed a 4.5 fold increase in the expression of pro-inflammatory cytokine interleukin 6 (IL-6) but not of other cytokines or markers of inflammation and oxidative stress. We hereby demonstrate that a short-term HFD significantly lowers SOL muscle GSH levels. This effect could be mediated through the increased expression of IL-6. Further, the skeletal muscle antioxidant defense could be impaired under cellular stress. We surmise that these early alterations could contribute to HFD-induced insulin resistance observed in longer protocols.

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Section: Discussionmentioning

confidence: 99%

A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats

et al. 2019

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“…Written informed consent was obtained from the study participants. For the power analysis, the study of Atar et al was got as reference (Atar et al., 2017 ). In that study, while the IL‐6 level was 33.8 + 29.8 ng/ml in the ED (‐) group, it was 56.9 + 26 ng/ml in the ED (+) group (Atar et al., 2017 ).…”

Section: Methodsmentioning

confidence: 99%

The effect of interleukin‐6 level at the time of hospitalisation on erectile functions in hospitalised patients with COVID‐19

et al. 2021

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We evaluated the relationship between erectile dysfunction (ED) and IL‐6 levels in males with COVID‐19. The study included 80 male patients aged 30–45 years who were hospitalised due to COVID‐19. The International Index of Erectile Function (IIEF‐5) questionnaire was used to assess erectile function. The IIEF‐5 questionnaire was re‐administered at a 3‐month control visit after discharge, and the change score from baseline was recorded. The patients were divided into three groups according to the IIEF‐5 score at 3 months as Group 1 (severe ED), Group 2 (moderate ED) and Group 3 (no ED), and into two groups according to IL‐6 level at the time of admission as Group A (IL‐6 ≤ 50 ng/ml) and Group B (IL‐6 > 50 ng/ml). The change in the IIEF‐5 score (p < .001) was significantly greater in Group B than in Group A. There was also significant difference in IL‐6 between Group 1 and Group 2 (p = .008). The correlation analysis revealed a moderate correlation between IL‐6 level and the change in IIEF‐5 score and D‐dimer level (r:0.529, p < .001) and a weak correlation between IL‐6 level and FSH (r:0.309, p = .005). The present study suggests that elevated IL‐6 levels in male patients hospitalised due to COVID‐19 might be related to the risk of developing ED.

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“…Agrawal et al 67 showed that endothelium-dependent flow-mediated dilation (FMD) is impaired in patients with PD who do not have risk factors such as atherosclerosis. Atar et al 68 showed that patients with early PD have more abundant IL-6 and pentraxin 3, and that this does not correlate with disease duration, degree of curvature, age, and level of C-reactive protein. These cytokines are released by endothelial cells, fibroblasts, monocytes as a result of traumatic events.…”

Section: Introductionmentioning

confidence: 99%

New insights into the pathogenesis of Peyronie's disease: A narrative review

Krakhotkin¹,

Chernylovskyi²,

Mottrie

et al. 2020

Chronic Diseases and Translational Medicine

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Peyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis. A growing body of literature has shown that PD is a chronically impaired, localized, wound healing process within the TA and the Smith space. It is caused by the influence of different pathological stimuli, most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features, imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP), and suppressed antioxidant systems during chronic inflammation. Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling. The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.

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Role of interleukin‐6 and pentraxin 3 as an early marker in Peyronie's disease

Cited by 12 publications

References 31 publications

A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats

A Short-Term High-Fat Diet Alters Glutathione Levels and IL-6 Gene Expression in Oxidative Skeletal Muscles of Young Rats

The effect of interleukin‐6 level at the time of hospitalisation on erectile functions in hospitalised patients with COVID‐19

New insights into the pathogenesis of Peyronie's disease: A narrative review

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