Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis

Yeniyol, Cem Özden; Sorguc, Sirri; Minareci, Süleyman; Ayder, Ali Rıza

doi:10.1016/s0090-4295(00)00491-x

Cited by 51 publications

(28 citation statements)

References 6 publications

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“…Results have been variable to date and not strong enough to justify the routine use of this treatment. A study by Yeniyol et al [69] showed testicular atrophy after interferon therapy in 38% of patients. This was confirmed with testicular biopsy during the follow-up.…”

Section: Treatmentmentioning

confidence: 98%

The increasing incidence of mumps orchitis: a comprehensive review

et al. 2010

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There has been a recent increase in mumps orchitis among pubertal and postpubertal males. These outbreaks can be attributed to a reduction in the uptake of measles‐mumps‐rubella (MMR) vaccine during the early to mid‐1990s in children who have now matured. The mumps virus is commonly associated with extra‐salivary complications. Unvaccinated postpubertal males diagnosed with mumps virus frequently develop complications such as mumps orchitis. Therefore, it is important that urologists are familiar with the diagnosis, treatment and complications of this condition. Here we review the epidemiology, clinical presentation, diagnostic methods, treatment options and complications of mumps orchitis, as a complication of mumps virus, with particular emphasis on testicular atrophy, subfertility and infertility.

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Section: Treatmentmentioning

confidence: 98%

The increasing incidence of mumps orchitis: a comprehensive review

et al. 2010

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“…Nausea, vomiting, fever, and fatigue may arise in severe cases [2]. The prevalence of bilateral involvement has been reported at varied rates of 16 and 65% [18,19]. Bilateral involvement was encountered in six of our cases.…”

Section: Discussionmentioning

confidence: 54%

Long-term efficacy and safety of interferon-alpha-2B in patients with mumps orchitis

et al. 2010

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The aim of this study was to determine long-term efficacy and safety subcutaneous injection of interferon-alpha-2B in patients with mumps orchitis in terms of testicular volume and other testicular functions. Mumps orchitis was evaluated in 37 patients. Patients were hospitalized and administered 1 × 3,000,000 IU subcutaneous injection of interferon-alpha-2B daily for 7 days. The testicular volumes of all the patients were measured by ultrasonography in the 18th month following treatment termination. The testes volumes were evaluated by descriptive statistics as percentages. Patients were divided into three groups according to testes volumes and differences between the involved and non-involved testicles. Group I included patients with normal testes volume (> 12 ml) and a difference between testes of less than 2 ml or 20%; Group II (atrophic groups) included patients with testes volume of less than 12 ml; and Group III (hypotrophic groups) included patients with testes volume of greater than 12 ml and a difference between testes of more than 2 ml or 20%. Groups were compared in terms of results of semen analysis and serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels. Patients' ages ranged between 17 and 41 years (mean: 28.3 years). A total of nine atrophy cases were identified. Sixteen patients were determined to have hypotrophic testes with a difference of 2-10 ml or 20% between the involved and non-involved testicles, despite the absence of testicular atrophy. A comparison of groups revealed that sperm density, total sperm count, total motile sperm count, and motility percentage were significantly higher in Group I than in the other groups, while serum FSH and LH levels were lower in Group I than in the other groups. Although the use of interferon-alpha-2B appears to prevent testicular atrophy and protect testicular function, it leads to a considerable difference in the volume between testicles and a significant loss of testicular function. As a result, further studies are required in order to investigate the efficacy of the drug.

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“…Im Hinblick auf spätere Fertilitätsstö rungen ist nach den verfügbaren Studien daten auch der präventive Effekt einer Be handlung der akuten Mumpsorchitis mit IFNα2B limitiert [16]. Pilotstudien zum präventiven Effekt einer DownRegulati on der Spermatogenese mit Gonadotro pinreleasingHormonagonisten bei Pa tienten mit akuter Orchitis bzw.…”

Section: Therapieoptionenunclassified

“…Typischerweise ma nifestiert sich die Orchitis 3-10 Tage nach Beginn der Parotitis, kommt jedoch auch ohne Parotitis vor. Trotz einer Therapie mit IFNα2b in der akuten Phase der Er krankung wiesen in einer FollowupStu die die Hodenbiopsien von 38% der Pati enten eine vollständige Atrophie der Tu buli seminiferi auf, in 16% der Fälle fand sich eine partielle Atrophie [16]. Verläss liche epidemiologische Daten zur Häufig keit einer Azoospermie bzw.…”

Section: Introductionunclassified

Orchitis und Infertilität

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Pilatz

Hossain

et al. 2010

Urologe

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Infections and inflammations of the genital tract are considered the most frequent causes of reduced male fertility, but conclusive epidemiological data are not available. In view of the exposure of germ cells to pathogenic components as well as the cells and mediators involved in the inflammatory processes, irreversible damage to spermatogenesis and corresponding decline of ejaculate quality are to be expected, particularly in cases of chronic orchitis. While the consequences of orchitis and epididymo-orchitis that exhibit clinical symptoms due to systemic or local infections are well known, including testicular atrophy and complete loss of fertility, those cases of inflammatory reactions of the testicles that manifest an asymptomatic or subclinical course, or are not even due to an infection, have received little attention until now. However, systematic histopathological analyses have shown a high prevalence of asymptomatic inflammatory reactions in testicular biopsies from infertile men. The mostly focal lymphocytic infiltrates correlate with the degree of damage to spermatogenesis and corresponding clinical and endocrinological parameters of testicular function. Noninvasive diagnostic techniques are not yet available so that chronic asymptomatic inflammations of the testicles as the primary cause or cofactor of male fertility disorders are underestimated. Except for administration of pathogen-specific antibiotics, treatment recommendations are to a large extent still lacking.

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Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis

Cited by 51 publications

References 6 publications

The increasing incidence of mumps orchitis: a comprehensive review

The increasing incidence of mumps orchitis: a comprehensive review

Long-term efficacy and safety of interferon-alpha-2B in patients with mumps orchitis

Orchitis und Infertilität

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