Role of increased mean platelet volume (<scp>MPV</scp>) and decreased <scp>MPV</scp>/platelet count ratio as poor prognostic factors in lung cancer

Omar, Muhyettin; Tanrıverdi, Özgür; Cokmert, Suna; Oktay, Esin; Yersal, Özlem; Pilancı, Kezban Nur; Menekşe, Serkan; Kocar, Muharrem; Şen, Cenk Ahmet; Ordu, Çetın; Göksel, Gamze; Meydan, Nezih; Barutça, Sabri

doi:10.1111/crj.12605

Cited by 51 publications

(55 citation statements)

References 33 publications

(117 reference statements)

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“…Most reports have shown that reduced MPV and/or MPV/P were linked to unsatisfactory prognosis in several carcinomas . However, in advanced NSCLC studied by Omar et al, they found elevated MPV and MPV/P could be an indicator of poor prognosis regarding OS, which is consistent with our current study. We conclude that this disparity maybe due to differing choice in cut‐off points and in the type of carcinomas studied.…”

Section: Discussionsupporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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Objectives To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X‐tile, and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis. Results The optimal cut‐off points of 171.4 for PLR, 260 × 109/L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P < .05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P < .05). Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.

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Section: Discussionsupporting

confidence: 92%

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Lau

Hsueh

Chen

et al. 2020

Clinical Otolaryngology

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“…The association between the inflammatory microenvironment and tumor prognosis has long been verified, and the prognostic value of the inflammatory parameters of NLR, PLR, and MLR has recently been revealed . To further investigate the prognostic value of various inflammatory parameters based on CBC, we performed this retrospective research in a single cancer center.…”

Section: Discussionmentioning

confidence: 99%

Elevated pretreatment neutrophil/white blood cell ratio and monocyte/lymphocyte ratio predict poor survival in patients with curatively resected non‐small cell lung cancer: Results from a large cohort

Cheng

Mao

et al. 2017

Thoracic Cancer

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BackgroundThe prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non‐small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in Chinese patients with curatively resected NSCLC.MethodsA total of 1466 consecutive NSCLC patients who received curative surgery from January 1, 2005 to December 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study. Correlations between each blood test parameter and overall survival were examined by Kaplan–Meier method or Cox proportional hazards regression, followed by a stratification analysis of significant variables.ResultsOptimal cut‐off values of 0.55 for neutrophil/white blood cell ratio (NWR), 0.28 for lymphocyte/white blood cell ratio (LWR), 0.09 for monocyte/white blood cell ratio (MWR), 2.06 for NLR, 0.35 for MLR, 204.00 for PLR, and 38.25 for platelet/white blood cell ratio (PWR) were identified using X‐tile software. Univariate analysis suggested that NWR ≥ 0.55, LWR < 0.28, MWR ≥ 0.09, NLR ≥ 2.06, MLR ≥ 0.35, and PLR ≥ 204.00 predicted a poor prognosis in NSCLC patients. However, only NWR and MLR were identified as independent significant prognostic factors in multivariable analysis, especially in tumor node metastasis stage I and I/II/III NSCLCs.ConclusionPretreatment NWR, MWR, LWR, NLR, MLR, and PLR values are associated with poor overall survival for patients with curatively resected NSCLC. NWR and MLR are independent prognostic factors in curatively resected NSCLC.

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“…Indeed, high platelet count is associated with increased mortality in a variety of cancers, including malignant mesothelioma (11), gynecologic malignancies (12), and breast cancer (13). In addition, platelet-to-lymphocyte ratio and mean platelet volume also add value in early diagnosis of lung cancer (14) and prognosis prediction (15,16). These findings, taken together, indicate that disordered platelet production may be connected to lung carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

Zhu

Wei

Zhang

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Results: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall nonsmall cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P ¼ 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P ¼ 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings.Conclusions: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention.Impact: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.

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Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer

Abstract: Unlike results of previous studies, the study showed that increased MPV was an important prognostic factor in patients with NSCLC. Hence, an increased MPV level may be used as a prognostic biomarker to estimate for poor overall survival in patients with NSCLC.

Cited by 51 publications

References 33 publications

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Elevated pretreatment neutrophil/white blood cell ratio and monocyte/lymphocyte ratio predict poor survival in patients with curatively resected non‐small cell lung cancer: Results from a large cohort

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis

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