Prognostic values of preoperative platelet‐to‐lymphocyte ratio and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Abstract

Objectives To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC). Methods The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment haematological parameters were categorised into two groups based on the result of X‐tile, and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis. Results The optimal cut‐off points of 171.4 for PLR, 260 × 109/L for platelet, 10.4 fL for mean platelet volume (MPV) and 16.5% for platelet distribution width were defined. The haematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion were statistically significant in OS and DFS analyses (P < .05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P < .05). Conclusions The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.

The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke

“…The PLR was demonstrated to be an independent predictor of diabetes with chronic complications [38][39][40] and tumors (such as non-small-cell lung cancer and hypopharyngeal squamous cell carcinoma) [41,42]. Recent studies proved that PLR is related to the prognosis of stroke thrombolysis [43] or endovascular treatment [44].…”

The Prognostic Capacity of Systemic Inflammation Response Index, Neutrophil-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio, and Platelet-to-Lymphocyte Ratio in Patients with Hypopharyngeal Squamous Cell Carcinoma

“…Our previous study showed that preoperative lymphocytes, NLR, PLR, and LMR are significantly associated with laryngeal squamous cell carcinoma (LSCC) progression, DFS, and cancer-specific survival and that these hematological parameters could be considered as independent prognostic values in patients with LSCC [5]. Another previous work showed that LMR is an independent prognostic factor in patients with HPSCC [38]. One of our recent studies proved that low PLR or mean platelet volume may be an independent predictor of better prognosis regarding both OS and DFS in patients with advanced HPSCC.…”

“…Given that the formation and development of tumors often require blood as the carrier, hematology markers and molecular biomarkers have gradually become the focus of most clinicians. Some studies have shown that parameters such as the preoperative NLR, PLR, and LMR are closely related to prognosis in patients with various cancers, such as head and neck squamous cell cancer [26,28,35,[37][38][39]. In addition, compared with many other prognostic factors, inflammation-based prognostic parameters offer the advantages of simplicity, wide usage, and low cost in terms of preoperative evaluations with blood tests.…”

High pretreatment platelet-to-lymphocyte ratio is related to poor prognosis in the squamous cell carcinoma of the larynx and hypopharynx in male patients

“…We consider 109.75, a value lower than 111.26, is inappropriate to be used as a practical cutoff, since a higher PLR is related to higher risks. PLR cutoff value for the hypopharynx was higher than their laryngeal counterparts, but due to limited hypopharyngeal cases, a critical appraisal was not separately made [19,20].…”