Elevated pretreatment neutrophil/white blood cell ratio and monocyte/lymphocyte ratio predict poor survival in patients with curatively resected non‐small cell lung cancer: Results from a large cohort

Abstract

BackgroundThe prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non‐small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in Chinese patients with curatively resected NSCLC.MethodsA total of 1466 consecutive NSCLC patients who received curative surgery from January 1, 2005 to December 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study. Correlations between each blood test parameter and overall survival were examined by Kaplan–Meier method or Cox proportional hazards regression, followed by a stratification analysis of significant variables.ResultsOptimal cut‐off values of 0.55 for neutrophil/white blood cell ratio (NWR), 0.28 for lymphocyte/white blood cell ratio (LWR), 0.09 for monocyte/white blood cell ratio (MWR), 2.06 for NLR, 0.35 for MLR, 204.00 for PLR, and 38.25 for platelet/white blood cell ratio (PWR) were identified using X‐tile software. Univariate analysis suggested that NWR ≥ 0.55, LWR < 0.28, MWR ≥ 0.09, NLR ≥ 2.06, MLR ≥ 0.35, and PLR ≥ 204.00 predicted a poor prognosis in NSCLC patients. However, only NWR and MLR were identified as independent significant prognostic factors in multivariable analysis, especially in tumor node metastasis stage I and I/II/III NSCLCs.ConclusionPretreatment NWR, MWR, LWR, NLR, MLR, and PLR values are associated with poor overall survival for patients with curatively resected NSCLC. NWR and MLR are independent prognostic factors in curatively resected NSCLC.

High pretreatment neutrophil‐to‐lymphocyte ratio as a predictor of poor survival prognosis in head and neck squamous cell carcinoma: Systematic review and meta‐analysis

“…Accumulated evidence suggests that inflammation plays an essential role in tumorigenesis and tumor progression, which is now included as a hallmark of cancer . The peripheral inflammatory cells and calculated ratios, especially neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR), have been demonstrated as independent prognostic biomarkers in various cancers, including breast cancer, esophageal carcinoma, colorectal carcinoma, and lung cancer . Opposing to the TNM staging system, which only represents the status of tumor, NLR and PLR could reflect the inflammatory status of host and supplement the TNM staging system.…”

Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)

“…Many studies have evaluated the role of absolute leucocyte, neutrophil, monocyte, lymphocyte or platelet count, ratios of various parameters like neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio among others and found conflicting results and a variety of threshold values with prognostic importance [9], [10], [11], [12], [13], [14]. However, most of these studies have evaluated patients with advanced stage or medically operable early stage NSCLC who underwent surgery.…”

Eosinophil‐to‐monocyte ratio is an excellent predictor of acute cellular rejection in pancreas transplant alone recipients

“…37 Studies regarding the monocyte count in peripheral blood have been performed in the field of cancer survival. 18,19,38 These studies reported that an elevated monocyte count has a worse effect on patients' survival. This finding suggests that an elevated monocyte count has an immunosuppressive effect.…”

“…The monocyte count is one of the key players in transplant immunology; however, reports about the relationship between the peripheral monocyte count and rejection are scarce . It is well known that a high monocyte count in peripheral blood has a deleterious effect on survival in patients with cancer …”

“…17 It is well known that a high monocyte count in peripheral blood has a deleterious effect on survival in patients with cancer. [18][19][20] According to these findings, a combination of the eosinophil count and monocyte count in peripheral blood may serve as a method for detecting acute rejection in pancreatic transplant recipients. The purpose of this study was to determine a biomarker of acute rejection that is easy to obtain and applicable in the clinical setting for recipients of pancreatic transplant alone.…”