Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study

Tamašauskienė, Laura; Gintauskienė, Viltė Marija; Bastyte, Daina; Šitkauskienė, Brigita

doi:10.1186/s12890-021-01410-z

Cited by 4 publications

(2 citation statements)

References 36 publications

(48 reference statements)

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“…Similarly, IL-22 and IL-22R upregulation was suggested in several studies in serum and in bronchial biopsies from asthmatic adults and children (predominantly in severe asthmatic patients) and in murine models of asthma, as well as in patients with other allergic respiratory diseases such as atopic rhinitis (99,(121)(122)(123)(124). IL-22 producing cells, particularly lymphocytes, are also increased in bronchial biopsies from asthmatic children (123).…”

Section: Involvement Of Il-17 and Il-22 In Asthmamentioning

confidence: 63%

Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives

et al. 2022

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Airway remodeling is a frequent pathological feature of severe asthma leading to permanent airway obstruction in up to 50% of cases and to respiratory disability. Although structural changes related to airway remodeling are well-characterized, immunological processes triggering and maintaining this phenomenon are still poorly understood. As a consequence, no biotherapy targeting cytokines are currently efficient to treat airway remodeling and only bronchial thermoplasty may have an effect on bronchial nerves and smooth muscles with uncertain clinical relevance. Th17 cytokines, including interleukin (IL)-17 and IL-22, play a role in neutrophilic inflammation in severe asthma and may be involved in airway remodeling. Indeed, IL-17 is increased in sputum from severe asthmatic patients, induces the expression of “profibrotic” cytokines by epithelial, endothelial cells and fibroblasts, and provokes human airway smooth muscle cell migration in in vitro studies. IL-22 is also increased in asthmatic samples, promotes myofibroblast differentiation, epithelial-mesenchymal transition and proliferation and migration of smooth muscle cells in vitro. Accordingly, we also found high levels of IL-17 and IL-22 in a mouse model of dog-allergen induced asthma characterized by a strong airway remodeling. Clinical trials found no effect of therapy targeting IL-17 in an unselected population of asthmatic patients but showed a potential benefit in a sub-population of patients exhibiting a high level of airway reversibility, suggesting a potential role on airway remodeling. Anti-IL-22 therapies have not been evaluated in asthma yet but were demonstrated efficient in severe atopic dermatitis including an effect on skin remodeling. In this review, we will address the role of Th17 cytokines in airway remodeling through data from in vitro, in vivo and translational studies, and examine the potential place of Th17-targeting therapies in the treatment of asthma with airway remodeling.

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Section: Involvement Of Il-17 and Il-22 In Asthmamentioning

confidence: 63%

Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives

et al. 2022

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“…Numerous studies exhibited the different result, such as study [27] who exhibited that in a mouse asthma model, IL-22 is essential for the development of antigen sensitization.…”

Section: Interleukin-22 Level Assessmentmentioning

confidence: 99%

Immunological Response in Asthmatic Patients: The Role of Iron Oxide Nanoparticles Against Klebsiella pneumoniae

Abdul,

Hussein,

Jaafar

2023

IJDNE

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Asthma, a prevalent respiratory disorder, is distinguished by airway obstruction and respiratory distress stemming from acute and chronic pulmonary inflammation. In this study, 150 sputum and nasopharyngeal swabs were collected from asthma patients, comprising 87 males and 63 females, specifically to isolate Klebsiella pneumoniae (K. pneumoniae). Additionally, blood samples were obtained from 35 patients at the Allergic Specialized Center, Baghdad, and 25 healthy individuals served as controls. All diagnoses were established by specialist respiratory physicians, and serums were preserved for later serological testing. A sandwich enzyme-linked immunosorbent assay was employed to ascertain the levels of total IgE, IL-4, and IL-22.The pathophysiology of bronchial asthma is intertwined with T-cell activation and fluctuations in cytokine levels. It was hypothesized that serum levels of total Immunoglobulin E (IgE) would be elevated in patients. Indeed, significant differences (p=0.001) were observed between patients' total IgE serum levels (304.33 ± 21.3 IU/mL) and controls (36.54 ± 0.69 IU/mL). Conversely, IL-4 and IL-22 levels in asthma patients (66.77 ± 4.1 pg/mL and 41.83 ± 0.37 pg/mL respectively) differed significantly from healthy controls for IL-4 (22.75 ± 0.68 pg/mL, p<0.01) but not for IL-22 (40.89 ± 1.35 pg/mL). Klebsiella pneumoniae was isolated from 12 sputum and nasopharyngeal swab samples from asthmatic patients. Postincubation, 83.3% of the isolates were found to be biofilm-forming, while 16.7% did not form biofilms. Iron oxide nanoparticles, with an average diameter of 85.9 nm, were utilized to inhibit K. pneumoniae biofilm formation. At a concentration of 5 mg/mL, these nanoparticles exhibited a significant augmentation of about 58% (p≤0.05) in inhibiting biofilm formation. However, at concentrations of 0.5mg/mL and 50 mg/mL, the augmentation was 42.9% (P>0.05) and 37.1% (p>0.05) respectively, which were not statistically significant.This study underscores the potential of iron oxide nanoparticles in impeding biofilm formation by K. pneumoniae and the pivotal role of cytokine levels in the pathophysiology of asthma.

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Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model

et al. 2021

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Background Allergic asthma is a chronic airway inflammatory disease with a number of cytokines participating in its pathogenesis and progress. Interleukin (IL)-22, which is derived from lymphocytes, acts on epithelial cells and play a role in the chronic airway inflammation. However, the actual role of IL-22 in allergic asthma is still unclear. Therefore, we explored the effect of IL-22 on allergic airway inflammation and airway hyperresponsiveness (AHR) in an ovalbumin (OVA)-induced asthma mouse model. Methods To evaluate the effect of IL-22 in an allergic asthma model, BALB/c mice were sensitized and challenged with OVA; then the recombinant mouse IL-22 was administered intranasally 24 h prior to each challenge. The IL-22 levels in lung homogenates and bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay, respectively. AHR was evaluated through indicators including airways resistance (Rrs), elastance (Ers) and compliance (Crs); the inflammatory cell infiltration was assessed by quantification of differential cells counts in BALF and lung tissues stained by hematoxylin and eosin (H&E); IL-22 specific receptors were determined by immunohistochemistry staining. Results The concentration of IL-22 was significantly elevated in the OVA-induced mice compared with the control mice in lung homogenates and BALF. In the OVA-induced mouse model, IL-22 administration could significantly attenuate AHR, including Rrs, Ers and Crs, decrease the proportion of eosinophils in BALF and reduce inflammatory cell infiltration around bronchi and their concomitant vessels, compared with the OVA-induced group. In addition, the expression of IL-22RA1 and IL-10RB in the lung tissues of OVA-induced mice was significantly increased compared with the control mice, while it was dramatically decreased after the treatment with IL-22, but not completely attenuated in the IL-22-treated mice when compared with the control mice. Conclusion Interleukin-22 could play a protective role in an OVA-induced asthma model, by suppressing the inflammatory cell infiltration around bronchi and their concomitant vessels and airway hyperresponsiveness, which might associate with the expression of its heterodimer receptors. Thus, IL-22 administration might be an effective strategy to attenuate allergic airway inflammation.

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Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study

Cited by 4 publications

References 36 publications

Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives

Role of Th17 Cytokines in Airway Remodeling in Asthma and Therapy Perspectives

Immunological Response in Asthmatic Patients: The Role of Iron Oxide Nanoparticles Against Klebsiella pneumoniae

Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model

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