Role of IGF1 in primary ovarian cancer – a study of the OVCAD European Consortium

Rohr, Irena; Zeilinger, Robert; Heinrich, Michaela; Richter, Ralf P.; Concin, Nicole; Vergote, I.; Mahner, Sven; Gorp, Toon Van; Trillsch, Fabian; Cacsire-Tong, Dan; Chekerov, Radoslav; Sehouli, Jalid; Braicu, EI

doi:10.1055/s-0034-1388347

Cited by 5 publications

(7 citation statements)

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“…29 Another study also proved that IGF1 level was up-regulated in plasma of well-differentiated epithelial ovarian cancer. 30 As Zhang et al state that miR-130a expression was markedly reduced in cisplatin-resistant ovarian cancer cells. 31 Epigenetic alterations of HOX genes can be correlated with PCOS and consequently female infertility, which provide insight for novel treatments with epidrugs for this disease.…”

Section: Discussionmentioning

confidence: 99%

Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Jiang

Xue

et al. 2019

J Cellular Molecular Medi

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It has been found that long noncoding RNA HOTAIR, microRNA‐130a (miR‐130a) and insulin‐like growth factor 1 (IGF1) expression are associated with ovarian cancer, thus, we hypothesised that the HOTAIR/miR‐130a/IGF1 axis might associate with endocrine disorders and biological behaviours of ovarian granulosa cells in rat models of polycystic ovary syndrome (PCOS). PCOS rat models were established by injection of dehydro‐isoandrosterone, followed by treatment of si‐HOTAIR, oe‐HOTAIR, miR‐130a mimics or miR‐130a inhibitors. Serum hormonal levels were determined to evaluate endocrine conditions. The effect of HOTAIR and miR‐130a on activities of isolated ovarian granulosa cells was assessed, as well as the involvement of IGF1.In the ovarian tissues and granulosa cells of PCOS rat models, highly expressed HOTAIR and IGF1 and poorly expressed miR‐130a were identified. In response to oe‐HOTAIR, serum levels of E2, T and LH were increased and serum levels of FSH were reduced; the proliferation of granulosa cells was reduced and apoptosis was promoted; notably, expression of miR‐130a was reduced while expression of IGF1 was increased. The treatment of si‐HOTAIR reversed the situation. Furthermore, the binding of HOTAIR to miR‐130a and targeting relationship of miR‐130a and IGF1 were confirmed. LncRNA HOTAIR up‐regulates the expression of IGF1 and aggravates the endocrine disorders and granulosa cell apoptosis through competitive binding to miR‐130a in rat models of PCOS. Based on our finding, we predict that competitive binding of HOTAIR to miR‐130a may act as a novel target for the molecular treatment of PCOS.

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Section: Discussionmentioning

confidence: 99%

Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Jiang

Xue

et al. 2019

J Cellular Molecular Medi

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“…The dysregulation of IGF axis and its role in promoting cancer has been investigated for many years (14). The higher serum levels of IGF-1 and lower of IGFBP-3 are generally considered to be linked to an increased risk, progression and mortality of many malignant tumors, namely breast and ovarian cancers (8,15,16), prostate (17) and nasopharyngeal carcinomas (18). Moreover, IGF axis can induce tumor-associated lymphangiogenesis and promote lymphatic metastasis (19).…”

Section: Discussionmentioning

confidence: 99%

“…In our cohort, we aimed to make provision for tumor location, but no significant differences in the serum levels of IGF-1 and IGFBP-3 between separate anatomic sites were revealed. In contrast to the logically increased IGF-1 and decreased IGFBP-3 levels in many cancers, lots of conflicting results are known in HNSCC (8,(15)(16)(17)(18). Zhi et al have described the trend for downregulation IGF-1, 2 and up-regulation of IGFPB-3 mRNA in laryngeal cancer and Brady et al reported lower circulating levels of both IGF-1 and IGFBP-3 in patients with oral cancers suggesting different pathobiology of carcinoma in these particular locations (21,22).…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of IGF-1 and IGFBP-3 in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas

Kalfeřt

Ludvíková

Topolčan

et al. 2017

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“…The weak correlation between IGF-1 and CA-125 levels was also demonstrated in women with serous epithelial OC. No association between IGF-1 expression and either clinicopathological data was observed [24].…”

mentioning

confidence: 88%

“…In the FP6 European Project "OVCAD", 275 consecutive primary epithelial ovarian cancers were included from women after radical cytoreductive surgery and platinum-based chemotherapy [24]. The authors analyzed the predictive and prognostic role of circulatory IGF-1 levels in these patients and found that an increased plasma IGF-1 concentration was significantly more frequent in welldifferentiated epithelial OC.…”

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confidence: 99%

IGF-1 Gene P1 Promoter Polymorphisms Influence Predisposition to Epithelial Invasive Ovarian Cancer

Cholewa¹

2018

BJSTR

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In 2011, the results of PLCO trial (Prostate, Lung, Colorectal, Ovarian Cancer Screening) have concluded that all screening tests have no contribution in a decrease of mortality due to ovarian cancer and in 2017 the results of a collaborative re-analysis from Ovarian Cancer Cohort Consortium suggested that IGF-1 concentrations are inversely associated with EOC risk independent of histological phenotype [4-5].The role of IGF system components in carcinogenesis of ovarian cancer was based on investigative epidemiological results, experiments in vivo and in vitro and on attempts of application of drugs affecting the IGF axis [6]. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, binding proteins, adaptor molecules) [6]. Such functions of IGF family as intensification of proliferation, inhibition of cell apoptosis as well as influence on cell transformation

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Role of IGF1 in primary ovarian cancer – a study of the OVCAD European Consortium

Cited by 5 publications

References 0 publications

Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Down‐regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin‐like growth factor 1 via microRNA‐130a

Serum Levels of IGF-1 and IGFBP-3 in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas

IGF-1 Gene P1 Promoter Polymorphisms Influence Predisposition to Epithelial Invasive Ovarian Cancer

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