IGF-1 Gene P1 Promoter Polymorphisms Influence Predisposition to Epithelial Invasive Ovarian Cancer

Abstract

In 2011, the results of PLCO trial (Prostate, Lung, Colorectal, Ovarian Cancer Screening) have concluded that all screening tests have no contribution in a decrease of mortality due to ovarian cancer and in 2017 the results of a collaborative re-analysis from Ovarian Cancer Cohort Consortium suggested that IGF-1 concentrations are inversely associated with EOC risk independent of histological phenotype [4-5].The role of IGF system components in carcinogenesis of ovarian cancer was based on investigative epidemiological results, experiments in vivo and in vitro and on attempts of application of drugs affecting the IGF axis [6]. Investigative hypotheses in original studies were based on biological functions manifested by the entire family of IGF (ligands, receptors, binding proteins, adaptor molecules) [6]. Such functions of IGF family as intensification of proliferation, inhibition of cell apoptosis as well as influence on cell transformation