Serum Levels of IGF-1 and IGFBP-3 in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas

Kalfeřt, David; Ludvíková, Marie; Topolčan, Ondřej; Čelakovský, Petr; Kučera, Radek; Windrichova, Jindra; Ludvík, Jaroslav; Skálová, Kateřina; Kulda, Vlastimil; Pešta, Martin; Plzák, Jan

doi:10.21873/anticanres.11693

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Igfbps As Biomarkers In Autoimmune Diseases1

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2018

2024

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Cited by 3 publications

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“…Recent studies also validated IGFBPs' role in the diagnosis and prognosis prediction in some solid tumor including nasopharyngeal carcinoma, ovarian cancer, pancreatic cancer, etc. (42–46). Despite the huge development of IGFBPs as biomarkers in cancer, there have been a number of studies focusing on the utility of IGFBPs as biomarkers in autoimmune diseases (Table 1).…”

Section: Igfbps As Biomarkers In Autoimmune Diseasesmentioning

confidence: 99%

Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases

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2018

Front. Endocrinol.

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Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent effects. In this review, we will discuss the structure and function of various IGFBPs, particularly IGFBPs as potential emerging biomarkers and therapeutic targets in various autoimmune diseases, and the possible mechanisms by which IGFBPs act on the pathogenesis of autoimmune diseases.

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Section: Igfbps As Biomarkers In Autoimmune Diseasesmentioning

confidence: 99%