Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients

Shaker, Olfat; Zahra, Amr; Sayed, Ahmed A.; Refaat, Ayman; El-Khaiat, Zakaria; Hegazy, Gehan A.; El-Hindawi, Khaled; Deen, Mohamed Ay-El

doi:10.2147/vhrm.s8143

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…Our results are strongly supported by those reported by Gaetani et al [9] in an Italian population and Shaker et al [20] in an Egyptian population, who found that the frequency of the mutant EE genotype of ICAM-1 gene in peripheral arterial patients was significantly higher than in controls. In addition, Pola et al [27] reported that the frequency of the EE genotype of ICAM-1 genotypes was 2-fold higher in stroke patients than in controls.…”

Section: Discussionsupporting

confidence: 93%

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Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

et al. 2012

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SummaryBackgroundThis study aimed to investigate the association of both intercellular adhesion molecule-1 (ICAM-1) and endothelial cell adhesion molecule (E-selectin) polymorphisms using PCR technique and their role in the pathogenesis of atherosclerosis.Material/MethodsThe study enrolled 285 individuals, classified into 4 groups: 63 cerebrovascular atherosclerotic patients, 75 cardiovascular patients, 72 peripheral atherosclerotic patients and 75 normal healthy individuals.ResultsThe frequency of the mutant AC genotype of E-selectin in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher than in control subjects (29.17%, 28.53% and 28% vs. 8%, respectively). However, no significant difference was observed in the frequency of mutant CC allele between all atherosclerotic patients and control groups. The frequency of the mutant EE homozygotes of ICAM-1 in peripheral, cerebral and cardiovascular atherosclerotic patients was significantly higher compared to controls (45.8%, 42.9% and 36% vs. 12%, respectively). The frequency of EK of ICAM-1 showed no significant difference between atherosclerotic patients and the control group. The frequency of the mutant E allele of ICAM-1 was significantly higher in peripheral, cerebral and cardiovascular patients compared to controls (58.3%, 54.8% and 54% vs. 26%, respectively).ConclusionsSer 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.

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Section: Discussionsupporting

confidence: 93%

“…This could be attributed to the polymorphism, which can functionally alter leukocyte-endothelial interactions. Similarly, Shaker et al [20] found that the distribution of the mutant AC genotype was significantly higher in peripheral atherosclerotic patients than in controls in an Egyptian population.…”

Section: Discussionmentioning

confidence: 89%

Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

et al. 2012

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“…Similarly, Lu et al10 found that K allele frequency was higher in CHD patients than in controls, and K allele carriers develop myocardial infarction more easily. In Egyptian patients with peripheral arterial occlusive disease, Shaker et al11 found a statistical difference in the clinical history and laboratory data between the EE and EK variants among those with ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

K469E polymorphism of the intercellular adhesion molecule-1 gene in Egyptians with coronary heart disease

Mohamed

Rashed

Amin

et al. 2010

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intercellular adhesion molecule-1 (ICAM-1). This study aimed to investigate the association of K469E polymorphism of the ICAM-1 gene and soluble ICAM-1 (sICAM-1) serum level with coronary heart disease (CHD) in Egyptian subjects.PATIENTS AND METHODS:Using a case-control design, we studied 100 patients with CHD, including 73 patients with acute myocardial infarction (MI) and 27 with unstable angina (UA). The control group consisted of 50 healthy subjects with normal left ventricular function. All participants were genotyped for the ICAM-1 polymorphism by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Serum sICAM-1 was measured by enzyme-linked immunoassay (ELISA).RESULTS:In CHD patients, the frequencies of K genotype (KK and EK) were significantly higher when compared to controls (P<.001) and were associated with an increased risk of disease development (OR=3.8, 95% CI: 1.7 to 8.5; P=.001). K genotype frequencies in patients with MI showed no significant difference when compared to patients with UA (P= .121). Serum sICAM-1 levels were comparable between CHD patients and controls (P= .37) and between MI and UA patients (P=.23). There were no significant differences in sICAM-1 levels among patients with different genotypes (P=.532). Men presented with higher sICAM-1 levels than women (P=.004).CONCLUSION:ICAM-1 gene polymorphism in codon 469 is associated with a risk for CHD development in Egyptian subjects. Serum sICAM-1 is not influenced by this polymorphism and is not necessarily elevated in CHD.

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“…The presence of 128R causes vascular inflammatory diseases by increasing binding affinity and attracting a variety of lymphocytes [27,28]. Studies have reported this polymorphism to contribute in the development of atherosclerosis, PAOD and ischemic stroke [19,26,29].…”

Section: Discussionmentioning

confidence: 99%