E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke

Das, Subhra; Roy, Sitara; Kaul, Subhash; Jyothy, A.; Munshi, Anjana

doi:10.1016/j.neulet.2014.08.032

Cited by 10 publications

(4 citation statements)

References 35 publications

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“…Indeed, when considering the common clinical cardiovascular risk factors for ischaemic and haemorrhagic stroke, it may be difficult to differentially weigh the risks for ischaemic and haemorrhagic stroke, especially in a population at high risk for both subtypes of stroke. Genetic testing or new biomarkers may be promising future tools to risk stratify for stroke [ 31 ]. To take the age-related preventive strategy and to set up more sensitive tools to risk stratify for ischaemic and haemorrhagic stroke could be helpful for reducing the global incidence of stroke.…”

Section: Discussionmentioning

confidence: 99%

Determinants and Time Trends for Ischaemic and Haemorrhagic Stroke in a Large Chinese Population

et al. 2016

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BackgroundThe clinical epidemiology of stroke has been widely investigated in Caucasian populations, but the changes over time in the proportion of ischaemic to haemorrhagic strokes is less clear, especially in the Chinese population.AimsOur objective was to study the determinants and time trends for ischaemic and haemorrhagic stroke, in relation to age, in a large Chinese population cohort.MethodsUsing a medical insurance database in the southwest of China from 2001 to 2012, time trends in age-adjusted ischaemic and haemorrhagic stroke incidence and the contributing risk factors associated with age were investigated.ResultsAmong 425,901 individuals without prior stroke (52.4% male, median age 54), the rate of ischaemic stroke (per 1000 patient-years) decreased between 2002–2007, then remained broadly similar between 2008–2012. The rate of haemorrhagic stroke showed a similar trend, being approximately 1.3–1.9 from 2008–2012. Compared to patients age<65, ischaemic and haemorrhagic stroke incidences (rate, 95% confidential interval, CI) were higher in the elderly population (age <65 versus age ≥65: ischaemic: 3.64, 3.33–4.00, vs 14.33, 14.01–14.60; haemorrhagic: 1.09, 1.00–1.10 vs 2.52,2.40–2.70, respectively, both p<0.001). There were no significant differences in haemorrhagic stroke rates between the elderly and the very elderly population. Ischaemic and haemorrhagic stroke shared similar risk factors (age, hypertension, coronary artery disease (CAD), vascular disease, and diabetes mellitus) (all p<0.05). In subjects age<75 years, CAD (7.17, 4.14–12.37) and diabetes mellitus (3.27, 2.42–4.42) contributed most to the developing of haemorrhagic stroke (all p<0.001). Amongst the very elderly, vascular disease (2.24, 1.49–3.37) was an additional major risk factor for haemorrhagic stroke, together with CAD and diabetes mellitus (all p<0.001).ConclusionIn this large Chinese cohort, there was an increased risk of ischaemic stroke compared to haemorrhagic stroke with ageing. CAD, vascular disease, diabetes mellitus, and hypertension were major contributors to the development of hemorrhagic stroke in the very elderly Chinese population.

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Section: Discussionmentioning

confidence: 99%

Determinants and Time Trends for Ischaemic and Haemorrhagic Stroke in a Large Chinese Population

et al. 2016

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“… 18 Polymorphism of E-selectin gene was related to the risk of hemorrhagic stroke in an Indian population. 19 The interaction of matrix metalloproteinase-9 (MMP-9) gene polymorphisms may be related to the wind direction of hemorrhagic stroke. 20 APOE , 21 RAGE, TNFRSF11B, Golgb1 , 22 LPL , 23 CRP , 24 KCNK17 25 polymorphisms, and some microRNAs 26 also play a role in hemorrhagic stroke.…”

Section: Discussionmentioning

confidence: 99%

ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Zhang¹,

Wei-wen²,

Pan³

et al. 2023

IJGM

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Background Hypertension is the main risk factor for hemorrhagic stroke. Aldehyde dehydrogenase 2 (ALDH2) may inhibit the occurrence of hypertension by anti-oxidative stress and vascular dilation. The purpose was to investigate the relationship of ALDH2 polymorphisms with hemorrhagic stroke in Hakka Chinese. Methods A total of 329 patients with hemorrhagic stroke and 515 controls were enrolled, and medical records (smoking and drinking history, hypertension, and diabetes) were collected. The genotypes of ALDH2 rs671 of the two groups were detected and analyzed. Results The proportion of the ALDH2 rs671 G/G, G/A, and A/A genotype in patients with hemorrhagic stroke was 55.9%, 37.4%, and 6.7%, respectively, while those were 65.0%, 30.7%, and 4.3% in controls, respectively. There was statistically significant difference in ALDH2 rs671 genotypes distribution ( P =0.021) and alleles distribution ( P =0.005) between patients and controls. Among hemorrhagic stroke patients, no statistically significant differences were observed between patients with ALDH2 different genotypes. Logistic regression analysis showed that there was significantly high risk of hemorrhagic stroke in men (male vs female: adjusted OR 1.711, 95% CI 1.154–2.538, P =0.008), the presence of hypertension (with vs without hypertension: adjusted OR 16.095, 95% CI 10.958–23.641, P <0.001), and the presence of ALDH2 rs671 G/A genotype (G/A vs G/G: adjusted OR 1.679, 95% CI 1.151–2.450, P =0.007) or A/A genotype (A/A vs G/G: adjusted OR 2.516, 95% CI 1.132–5.591, P =0.024). Conclusion ALDH2 rs671 polymorphism likely a risk factor for hemorrhagic stroke.

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“…In these SNPs, the serine is substituted by arginine in exon 4 at position 128 or 149 in the Epidermal Growth Factor (EGF) domain of the protein, respectively. Das S, et al [24] reported that this substitution in E-selectin S128R affects its ligand binding affinity and increases the adhesiveness of leukocytes to the endothelium. In our case-control study, we examined the association between these two SNPs and SCD in the Congolese population, using the PCR-RFLP method for the genotyping.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism and Association of the E-selectin and ICAM-1-K469E Genes with Sickle Cell Disease in Congo

FR,

LT,

et al. 2023

J Blood Disord Med

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Introduction: E-selectin and ICAM-1 are cellular adhesion molecules that play important roles in the pathogenesis of Sickle Cell Disease (SCD), especially in the vaso-occlusion process. Numerous studies reported that single nucleotide polymorphisms in E-selectin and ICAM-1 genes may be associated with the clinical expression of several diseases. However, no evidence exists regarding the association with SCD. Objectives: Investigate the association of E-selectins (S128R and S149R) and ICAM-1K469E polymorphisms with SCD in Congolese patients. Methodology: This case-control study included 110 SCD patients in vaso-occlusive pain crisis and 120 controls (healthy non-sickle cell subjects). Polymorphisms were genotyped by PCR-RFLP method. The differences in genotype and allele frequencies between both groups were analyzed with the Fisher’s exact test. A P level of <0.05 was considered significant. Results: The frequency of the ICAM-1-K469E EE genotype was significantly higher in SCD patients compared to controls (8.2% vs 0.8%; P=0.008). The odd ratio value (OR=11.89; 95% CI = 1.48-96.53; P=0.01) indicated a high association with SCD. Furthermore, the E allele was also significantly associated with SCD (OR=1.72; 95% CI=1.10-2.68; P=0.008). By contrast, no statistically significant differences were found between SCD patients and controls regarding the allele and genotype frequencies of E- selectin S128R and S149R polymorphisms. Conclusion: Our findings suggest that the ICAM-1-K469E polymorphism may be associated with SCD among Congolese patients, possibly with the vaso-occlusive crisis. The EE genotype and the E allele may be genetic risk factors. However, because of the small sample size, this report should be considered as exploratory and further studies are required to confirm these genetic associations with SCD.

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E-selectin gene (S128R) polymorphism in hemorrhagic stroke: Comparison with ischemic stroke

Cited by 10 publications

References 35 publications

Determinants and Time Trends for Ischaemic and Haemorrhagic Stroke in a Large Chinese Population

Determinants and Time Trends for Ischaemic and Haemorrhagic Stroke in a Large Chinese Population

ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Polymorphism and Association of the E-selectin and ICAM-1-K469E Genes with Sickle Cell Disease in Congo

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