Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

Motawi, Tarek K.; Shaker, Olfat; Taha, Noha; Raheem, Marwa Abdel

doi:10.12659/msm.882908

Cited by 23 publications

(16 citation statements)

References 30 publications

(40 reference statements)

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“…The mechanisms of the proinflammatory effects of ICAM-1 on endothelial cells might be that ICAM-1 binds and interacts with leukocyte integrin receptors such as lymphocyte function-associated antigen-1 LFA-1 and Mac-1 [41] . ICAM-1 also serves as a receptor for soluble fibrinogen, which mediates leukocyte adhesion to the endothelium through an ICAM-1 dependent pathway [42] . Study from Kanter et al [43] demonstrated that cPKCβII mediates insulin resistance in part by stimulating threonine phosphorylation of the PI3K, which in turn blunts insulin-stimulated Akt-eNOS activation and then upregulates the expression of VCAM-1 and ICAM-1.…”

Section: Discussionmentioning

confidence: 99%

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Feng

Wang³

2015

Blood Purif

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Background/Aims: To evaluate the relationship between plasma hydrogen sulfide (H₂S) and cardiovascular risk markers, including pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in chronic hemodialysis (CHD) patients and further investigate the underlying cardiovascular protection mechanism of H₂S. Methods: CHD patients, 113 of them, were studied. Plasma H₂S was measured through zinc acetate reaction. cPKCβII membrane translocation and phosphorylation of Akt were detected by western blot. Results: Lower plasma H₂S level in CHD patients was predictor of an increased PP, LVMI and IMT. Patients with lower H₂S had a lower survival at the end of the study. H₂S was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. CHD patients with lower H₂S showed an increase of cPKCβII activation, but phosphorylation of Akt decreased. The level of VCAM-1 and ICAM-1 increased significantly. Conclusions: Lower plasma H₂S in CHD patients is associated with cardiovascular risk factors and mortality, which may be mediated by the cPKCβII/Akt pathway and further VCAM-1/ICAM-1 upregulation.

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Section: Discussionmentioning

confidence: 99%

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Feng

Wang³

2015

Blood Purif

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“…However, a relationship between HCY and cardiovascular status in patients with mood disorders has not been studied so far. Recently, proteins such as E-selectin and intracellular adhesion molecule-1 (ICAM-1) were considered as markers of endothelial functions and postulated as involved in genetic predisposition to atherosclerosis [10]. Therefore, it would be of interest to know how HCY relates to the markers of endothelial functions in patients with mood disorder.…”

Section: Introductionmentioning

confidence: 99%

Hyperhomocysteinemia in Bipolar Depression: Clinical and Biochemical Correlates

Permoda-Osip

Dorszewska²,

Skibińska

et al. 2013

Neuropsychobiology

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Background: Depression may be associated with elevated homocysteine (HCY) levels. Procedures aiming at its decrease, i.e. supplementation with folic acid or vitamin B₁₂, have antidepressant effect. Both depression and elevated HCY can increase cardiovascular risk. In this study, clinical and biochemical factors, including markers of endothelial function, in relation to hyperhomocysteinemia, in patients with bipolar depression during acute episode were studied. Method: One hundred and twelve patients (24 male, 88 female), aged 20-78 (mean 51 ± 14 years), with depressive episode in the course of bipolar mood disorder have been included. The assays were made of serum concentrations of HCY, vitamin B₁₂, folic acid as well as markers of endothelial function such as E-selectin and intracellular adhesion molecule-1 (ICAM-1). Results: Hyperhomocysteinemia (>15 mM)was found in 50 patients (45%), significantly more frequently in male (67%) than in female subjects (39%). Female patients with hyperhomocysteinemia were significantly older than the remaining ones. A significant inverse correlation between HCY level and concentration of folic acid and vitamin B₁₂ as well as with E-selectin and ICAM-1 was observed. Conclusion: The results point to a significant prevalence of hyperhomocysteinemia in bipolar depressed patients during an acute episode. They also corroborate the correlation between increased concentration of HCY and lower level of vitamin B₁₂ and folic acid. An unexpected finding of negative correlation of HCY level with markers of endothelial functions in such patients is discussed in view of current concepts of the role of HCY in various conditions.

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“…Of the 20 studies included, only 6 were Caucasian studies, which may have affected the true association of Caucasian ICAM-1 polymorphism with ischemic stroke. (Flex et al, 2004;Li et al, 2009;Mohy et al, 2015;Motawi et al, 2012;Pola et al, 2003;Volcik et al, 2010). Thus, additional studies with larger cohorts are necessary.…”

Section: Discussionmentioning

confidence: 99%

“…Fifteen studies were from China (Geng, 2011;Guo, Liu, & Guo, 2011;Huihua et al, 2016;Li et al, 2009;Liu, 2005;Shang, 2004;Sun & Zhang, 2005;Sun, Wu, & Deng, 2009;Wang et al, 2015;Wei, Liu, Huang, Tang, & Meng, 2005;Xing, Song, Hongjun, & Zhang, 2006;You, Huang, & Liu, 2007;Zhang, Cheng, Peng, Wang, & Peng, 2007;Zhang & Zhang, 2012;Zhou, Zhu, & Sun, 2007), two studies were from Italy (Flex et al, 2004;Pola et al, 2003), two studies from Egypt (Mohy, Ali, & Omar, 2015;Motawi, Shaker, Taha, & Abdel Raheem, 2012), one study was from the United States (Volcik, Ballantyne, Hoogeveen, Folsom, & Boerwinkle, 2010). Caucasian subjects were included in six studies (Flex et al, 2004;Geng, 2011;Mohy et al, 2015;Motawi et al, 2012;Pola et al, 2003;Volcik et al, 2010), black subjects were included in one (Volcik et al, 2010), and Asians were included in rest of the studies. The publication date ranged from 2003 (Pola et al, 2003) to 2016 (Huihua et al, 2016).…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was most common form of genotyping. However, some studies used TaqMan PCR (Volcik et al, 2010), T-gradient PCR (Motawi et al, 2012), and TaKaRa PCR kits (Wang et al, 2015). Controls were population-based in the 16 studies but hospital based in four (Flex et al, 2004;Liu, 2005;Pola et al, 2003;Zhang et al, 2007).…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

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Association between K469E polymorphism of ICAM‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis

Nepal

Yadav

Kong

2019

Molec Gen & Gen Med

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Background The intercellular adhesion molecule‐1 (ICAM‐1)/leukocyte function associated antigen‐1 (LFA‐1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. Therefore, single nucleotide polymorphisms (SNPs) of the ICAM‐1 gene may strongly influence the expression and biological activity of ICAM‐1 and play a potentially important role in the pathogenesis of ischemic stroke. In the current meta‐analysis, we investigated the relationship between the ICAM‐1 gene K469E SNP and the risk of ischemic stroke. Methods Two investigators independently searched PubMed, Web of Science, Google Scholar, WANFANG, China National Knowledge Infrastructure (CNKI) and J‐STAGE for studies published from January 2000 to February 2019 without language restriction. The association of K469E polymorphism and ischemic stroke in three genetic models (allelic, recessive, and dominant) were evaluated using Pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results Our study included 20 studies from four continents and four different countries, including 3,137 cases and 15,382 controls. Meta‐analysis results did not show a significant association between K469E polymorphism of ICAM‐1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I 2 = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I 2 = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I 2 = 85%). However, in all three genetic models, subgroup analysis revealed that the K469E polymorphism of the ICAM‐1 gene is associated with ischemic stroke in the Caucasian population. Conclusion K469E polymorphism of ICAM‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.

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Genetic variations in E-selectin and ICAM-1: Relation to Atherosclerosis

Cited by 23 publications

References 30 publications

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Hyperhomocysteinemia in Bipolar Depression: Clinical and Biochemical Correlates

Association between K469E polymorphism of ICAM‐1 gene and susceptibility of ischemic stroke: An updated meta‐analysis

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