Role ofVDR,GC, andCYP2R1Polymorphisms in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients

Barooah, Prajjalendra; Saikia, Snigdha; Bharadwaj, Rituraj; Sarmah, Preeti; Bhattacharyya, Mallika; Goswami, Bhabadev; Medhi, Subhash

doi:10.1089/gtmb.2018.0170

Cited by 20 publications

(21 citation statements)

References 36 publications

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“…Our study revealed that patients with HCC had a higher frequency of Apa-I CC genotype compared to those with chronic hepatitis C or control. These results are similar to those found by Barooah [22,25,28]. Hung et al (2014) revealed that patients carrying the corresponding APa-1 CC genotype had a higher prevalence of HCC than those with CA or AA type.…”

Section: Discussionsupporting

confidence: 89%

“…There was a significant difference between HCC and control regarding age but not significantly higher than chronic hepatitis patients. These results were similar to those found by Barooah et al (2019) [22]. In contrary to our results, Yang and Roberts (2010) reported that the risk of HCC is 2-7 times higher in men than in women, although this ratio varies across the world.…”

Section: Discussionsupporting

confidence: 84%

“…Moreover, a significant difference between control and chronic hepatitis groups regarding all parameters except AFP, serum creatinine, and urea. Similar results were found by Barooah et al (2019) and Raafat Rowida et al (2020). They reported that serum levels of ALT, AST, and bilirubin were higher among patients of HCC than those of chronic liver disease [22,25].…”

Section: Discussionsupporting

confidence: 84%

“…Similar results were found by Barooah et al (2019) and Raafat Rowida et al (2020). They reported that serum levels of ALT, AST, and bilirubin were higher among patients of HCC than those of chronic liver disease [22,25]. Also, Bruix and Sherman (2011) showed that the serum level of ALT and AST were elevated in HCC especially the advanced cases, and the difference becomes greater as the disease progresses [26].…”

Section: Discussionsupporting

confidence: 72%

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Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Mosaad

Emam

Hamed

et al. 2020

Egypt Liver Journal

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Background Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide. Vitamin D receptor (VDR) gene polymorphisms were linked to different cancers. This study was carried out to assess the possible relation between VDR gene polymorphism and the occurrence of HCC in chronic hepatitis C patients. This study included 102 subjects classified into three groups. Group A included 34 healthy subjects as control. Group B included 34 chronic hepatitis C patients with HCC. Group C included 34 chronic hepatitis C patients without HCC. Estimation of Apa-1 VDR gene polymorphism was performed by restriction fragment length polymorphism-Polymerase chain reaction (RFLP-PCR). Results In HCC group, C allele was more frequent than A allele (80.88% and 19.12%), respectively. In chronic hepatitis group, C allele was more frequent than A allele (64.71% and 35.29%), respectively. In control group, A allele was more frequent than C allele (73.53% and 26.47%), respectively. Genotype CC + CA was dominant in HCC group (91.18%) and chronic hepatitis group (79.41%). In the control group, the dominant genotype was AA (58.82%). Moreover, there was a significant relation between Apa-1 VDR genotype CC and tumor size. Conclusions There is an association between VDR Apa-1 polymorphism and the occurrence of HCC in chronic hepatitis C patients.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 72%

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Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Mosaad

Emam

Hamed

et al. 2020

Egypt Liver Journal

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“…VDR BsmI and TaqI variants affected the progression of fibrosis in HCV patients [76]. When Barooach et al determined whether VDR, VDBP, and CYP2R1 gene polymorphisms are risk factors for clinical complications in HCV-related HCC patients, they identified the VDR ApaI CC genotype and the VDR bAt haplotype as independent predictors for cirrhosis and HCC development in HCV patients [77]. When Langer et al performed a similar study to investigate the potential link between CYP2R1, VDBP, and DHCR7 genotypes and the risk of HCV-related HCC development by using 1279 HCV-related HCC patients, they found a functionally relevant role for VD in the prevention of HCV-related HCC [44].…”

Section: Effect Of Vdrg Polymorphisms On Hcv Pathogenesismentioning

confidence: 99%

Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

Lee

2020

Nutrients

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Vitamin D (VD) plays an essential role in mineral homeostasis and bone remodeling. A number of different VD-related genes (VDRG) are required for the metabolic activation of VD and the subsequent induction of its target genes. They include a set of genes that encode for VD-binding protein, metabolic enzymes, and the VD receptor. In addition to its well-characterized skeletal function, the immunoregulatory activities of VD and the related polymorphisms of VDRG have been reported and linked to its therapeutic and preventive actions for the control of several viral diseases. However, in regards to their roles in the progression of viral diseases, inconsistent and, in some cases, contradictory results also exist. To resolve this discrepancy, I conducted an extensive literature search by using relevant keywords on the PubMed website. Based on the volume of hit papers related to a certain viral infection, I summarized and compared the effects of VD and VDRG polymorphism on the infection, pathogenesis, and treatment outcomes of clinically important viral diseases. They include viral hepatitis, respiratory viral infections, acquired immunodeficiency syndrome (AIDS), and other viral diseases, which are caused by herpesviruses, dengue virus, rotavirus, and human papillomavirus. This review will provide the most current information on the nutritional and clinical utilization of VD and VDRG in the management of the key viral diseases. This information should be valuable not only to nutritionists but also to clinicians who wish to provide evidence-based recommendations on the use of VD to virally infected patients.

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Vitamin D and antiviral immunity

Kalia,

Sarkar

2024

Feldman and Pike's Vitamin D

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Role ofVDR,GC, andCYP2R1Polymorphisms in the Development of Hepatocellular Carcinoma in Hepatitis C Virus-Infected Patients

Cited by 20 publications

References 36 publications

Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Controversial Effects of Vitamin D and Related Genes on Viral Infections, Pathogenesis, and Treatment Outcomes

Vitamin D and antiviral immunity

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