Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature

Gupta, Shikha; Gupta, Sunita

doi:10.4103/0975-962x.155877

Cited by 64 publications

(89 citation statements)

References 61 publications

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“…HPV has a special tropism for basal keratinocytes, and the viral genome undergoes episomal replication during the initial phase of infection, with a few copies of viral DNA per host cell present [7]. The episomal form acts as a reservoir of infected cells and is responsible for the latent state of infection [7], however not all contact with HPV may became productive infection; the host's immune system is sometimes capable of keeping the virus in latency, or it may be sufficient to eliminate the virus before it integrates into the host cell genome [25].…”

Section: Resultsmentioning

confidence: 99%

“…For a long time it was believed that HPV could not be transmitted to various locations of the body through the blood, however, various studies have demonstrated that the DNA of HPV may be found in the blood circulation, including the peripheral blood mononuclear cells (PBMC), serum, plasma, umbilical cord and arterial blood [8]. Blood plasma has been shown to be an attractive medium for the detection of infection by HPV, since it is a non-invasive method, and blood is the only fluid that is in direct contact with all the organs [9], however, there are no studies that have made the association of the rate of detection of HPV in blood plasma with that of tissue obtained from patients with oral leukoplakia.…”

Section: Introductionmentioning

confidence: 99%

“…Tissue would be the best source for analyzing the rate of HPV infection, since it is an epitheliotropic virus, and presents its proliferation in the cells of the basal and parabasal layer of the epidermis or mucosa, establishing its infection in the more superficial layers of the epithelium [7]. For a long time it was believed that HPV could not be transmitted to various locations of the body through the blood, however, various studies have demonstrated that the DNA of HPV may be found in the blood circulation, including the peripheral blood mononuclear cells (PBMC), serum, plasma, umbilical cord and arterial blood [8].…”

Section: Introductionmentioning

confidence: 99%

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Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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“…HPV 16 antibodies are said to contribute to the increased risk of HPV associated oral cancer [13]. However, malignant potential of HPV is hypothesised but not definitely confirmed [14]. Various studies on the HPV prevalence accounting to the development of oral squamous cell carcinoma have also been done in countries like-Chile [15], China, California etc.…”

Section: Discussionmentioning

confidence: 99%

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pal¹,

Raychowdhury²,

Halder³

2016

Otolaryngol (Sunnyvale)

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Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods:Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively.Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 µg/g). Conclusion:A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

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“…On the basis of the morphological similarities between oropharyngeal and genital epithelia, it may suggest that HPVs are more likely to play a role in the early stage of oral carcinogenesis [1] .…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus (HPV) Detection in Keratotic Variants of Oral Lichen Planus: Negative Results in a Preliminary Open Study

2017

ARC Journal of Dental Science

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Abstract:Background During the last few decades, several researches have been identified HPV genomic sequences in Head Neck Squamous Cell Carcinomas (HNSCC) and in Oral Potentially Malignant Disorders (OPMD) hypothesizing a possible viral etiological role. However, the reported prevalence of HPV-DNA (varying from 0% to 100%) in these lesions result still very discordant.Objective Human papillomavirus (HPV) infection in Oral Lichen Planus (OLP) has been largely investigated but not so extensively with respect to its morphological/histopathological features. The possible influence of hyper-keratosis/parakeratosis in HPV detection for keratotic variants of OLP is here proposed and investigated.Materials and methods A total of 45 individuals with keratotic variants of OLP, clinically and histologically confirmed, were consecutively enrolled, before starting any treatment, and underwent oral brushing for HPV investigation. Viral DNA was extracted from oral brushed cells and HPV DNA researched by the combined use of the INNO-LiPA HPV Genotyping system (Innogenetics) and a PCR assay coupled with genome sequencing.Results None of cytological samples collected resulted HPV-positive. ConclusionsIn this preliminary study, oral HPV infection, investigated by means of a non-invasive oral sampling procedure and a standardized approach for HPV DNA detection, was not showed in any of the investigated cases. The presence of epithelial hyper-keratosis/parakeratosis in some variants of OLP could be a possible cause of impenetrability and/or difficult detection of the virus. Indeed, in case of keratotic variants of OLP, the possible potential false-negative results of HPV investigation by cytological procedure might be possible; on consequence, an alternative approach for viral detection (i.e. by histological sampling) should be considered.

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Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature

Cited by 64 publications

References 61 publications

Plasma HPV DNA is detectable in oral leukoplakia patients

Plasma HPV DNA is detectable in oral leukoplakia patients

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Human Papillomavirus (HPV) Detection in Keratotic Variants of Oral Lichen Planus: Negative Results in a Preliminary Open Study

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