Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Abstract

Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods:Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively.Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 µg/g). Conclusion:A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

Cytogenetic and micronuclei study of human papillomavirus-related oral squamous cell carcinoma

“…[16] This is also contradicted by another study of West Bengal. [17] In India, HPV DNA has been detected less frequently in tumor specimens from individuals having habits of predisposing risk factors than the nonusers. [18] This is also consistent with another in Kerala which says that negative history of tobacco usage has shown a trend toward HPV positivity in OSCC patients.…”