Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

Olivo-Dı́az, Angélica; Hector, Debaz; Aláez, C.; Islas, Víctor Juárez; Pérez-Pérez, Héctor; Hobart, Oscar; Gorodezky, Clara

doi:10.1016/j.humimm.2003.12.008

Cited by 28 publications

(18 citation statements)

References 32 publications

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“…66 A study in Mexican mestizos showed that HLA-DQ3 antigen and HLA-DRB1*0407, -DQA1*3011, -DPA1*0401 and -DPB1* 0101 alleles were associated with susceptibility for LCL, whereas the HLA-DR2 group (-DRB1*1500, -DRB1*1600) and HLA-DPB1*0401 allele was associated with protection. 63 A previous study in this same population showed a significant increase of HLA-DQ3 antigen and a decrease of -DPw4 antigen in patients affected with LCL. 67 In Brazilians, Petzl-Erler et al investigated the association of MCL with Classes I and II HLA molecules in Caucasians and mulattos; no significant difference was found for Class I HLA antigens between patients and controls.…”

Section: Cutaneous Leishmaniasismentioning

confidence: 69%

“…The type of syndrome developed depends on the interaction between the protozoon species of Leishmania and the host immune and genetic status. 62,63 Regarding the association of cutaneous leishmaniasis with class I HLA antigens, Barbier et al reported a low frequency of HLA-Cw7 antigen. 64 In the Egyptian population, a significant association was found between Class I HLA-A11, -B5 and -B7 antigens and DCL.…”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

“…66 in Mexican Mestizos with LCL, 67 in Brazilian Caucasians and Mulattos with MCL. 68 HLA-DR2 antigen is associated with protection in Mexicans 63 and in Brazilians. 68 HLA-DQw3 and -DR2 antigens may be probable markers of risk and genetic protection, respectively, for cutaneous leishmaniasis.…”

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

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Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Alves

Vieira

Meyer

et al. 2006

An. Bras. Dermatol.

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Abstract:The participation of the human histocompatibility system (HLA: human leukocyte antigens) in the pathogenesis of autoimmune diseases is well known. Situated on the short arm of chromosome 6, the HLA system is very polymorphic and has the capacity to confer susceptibility or resistance to different diseases. In Dermatology, this system has an important participation in the pathogenesis and natural course of various diseases. The strength and type of association differ with conditions and sometimes with the ethnic-racial group studied. The discovery of molecular methods to typify HLA alleles and recent updates in its nomenclature has contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted in the literature, hindering identification of the association of the HLA with skin diseases. In this review, some aspects of the HLA system are discussed, such as methods of detection, nomenclature and association with vitiligo, pemphigus, psoriasis, lupus erythematosus, scabies, cutaneous leishmaniasis, leprosy, paracoccidiodomycosis and atopic dermatitis.

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Section: Cutaneous Leishmaniasismentioning

confidence: 69%

Section: Cutaneous Leishmaniasismentioning

confidence: 99%

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Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Alves

Vieira

Meyer

et al. 2006

An. Bras. Dermatol.

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“…Some studies have shown an association of HLA class II with ACL (Petzl-Erler et al, 1991;Olivo-Díaz et al, 2004;Ribas-Silva et al, 2013). Considering this, future studies should also be performed using markers for HLA class II in southern Brazil.…”

Section: Discussionmentioning

confidence: 98%

Association between HLA-C*04 and American cutaneous leishmaniasis in endemic region of southern Brazil

Ribas-Silva¹,

Ribas²,

Ferreira³

et al. 2015

Genet. Mol. Res.

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“…176 Due to advances in science and technology, there is evidence to support the fact that the genetic background of the host and the immune response play an important role in the outcome of the leishmaniasis disease. [176][177][178][179][180][181][182][183][184][185][186] One of the first studies assessing the potential association between HLA and cutaneous leishmaniasis involving serological methods was under taken in France, with Leishmania guyanensis. 180 The study revealed the association of a low HLA-Cw7 frequency with pathogenesis of cutaneous leishmaniasis.…”

Section: Hla and Leishmaniasismentioning

confidence: 99%

Major histocompatibility complex and its importance towards controlling infection

Longjam

Das

2017

Asian J Med Sci

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It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response during infection could be under genetic control. The Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) system is the most intensively studied of all genetic systems because of its influence to many important traits, including resistance to infectious diseases, autoimmunity and immunological self or nonself compatibility. This is understandable in the light of the evolutionary pressure so that we are equipped to face the multitude of infectious challenges. Infectious diseases are a major selective pressure;and genes involved in the immune response are the most numerous and diverse in the human genome; reflecting the evolutionary advantages of a diverse immunological response to a wide range of infectious pathogens.Asian Journal of Medical Sciences Vol.8(2) 2017 1-13

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Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

Cited by 28 publications

References 32 publications

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Antígenos de histocompatibilidade humanos e dermatologia: da pesquisa para a prática clínica

Association between HLA-C*04 and American cutaneous leishmaniasis in endemic region of southern Brazil

Major histocompatibility complex and its importance towards controlling infection

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