Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions

Wang, Ru; Ji, Qiuxia; Meng, Chenda; Liu, Hanyun; Fan, Chun; Lipkind, Sofya; Wang, Zhiguo; Xu, Quanchen

doi:10.1016/j.intimp.2019.106030

Cited by 61 publications

(53 citation statements)

References 66 publications

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“…In detail, one study used stem cells from inflamed periodontal ligaments, not from the gingiva [ 9 ], one study did not use the inflamed gingival source (irrelevant intervention) [ 25 ], and one study used inflammatory cytokine-treated cells without untreated or healthy control groups [ 26 ]. Correspondingly, three studies used extracellular vesicles or external factors including microvesicles [ 27 ], epigenetic modification [ 28 ], and Retinol [ 29 ], as well as one study used stem cells obtained from healthy gingiva in an inflammatory animal model [ 30 ]. Thus, 13 studies were included in the current scoping review ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

The Therapeutic Potential of Inflamed Gingiva-Derived Mesenchymal Stem Cells in Preclinical Studies: A Scoping Review of a Unique Biomedical Waste

Al-Qadhi

Al-Rai

Hafed

2021

Stem Cells International

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Searching for considerable abundance, simple, and accessible sources in stem cell-based therapy opens the door for isolation of a new population of oral/dental stem cells known as inflamed gingiva-derived mesenchymal stem cells, which have recently come to light with promising therapeutic potential in tissue regenerative therapy. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines, this scoping review is aimed at highlighting the possible therapeutic potential of inflamed gingiva-derived mesenchymal stem cells in preclinical studies carried out to date and presenting the current evidence depends upon their comparison to the healthy gingiva-derived mesenchymal stem cells or other mesenchymal stem cell sources. A comprehensive electronic search using (PubMed, Embase, Scopus, and Web of Science) databases and a manual search of relevant references were conducted until June 2020. Included studies were assessed using a combination tool, including the guidelines for reporting preclinical in vitro studies on dental materials, which were based on the modification of the Consolidated Standards of Reporting Trial checklist and the guidelines for animal research: reporting of in vivo experiments. The initial research provided 360 articles, with 13 articles that met the inclusion criteria. While most of the included studies lacked randomization, blinding, and sample size calculation, they were designed accurately in other aspects of the guidelines. The results of this scoping review indicated that inflamed gingiva-derived mesenchymal stem cells could be effective in terms of osteogenic differentiation, collagen fiber formation, immunoregulation, migration capacity, and testing of dental material and may present a reliable alternative source for healthy gingiva-derived mesenchymal stem cells.

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Section: Resultsmentioning

confidence: 99%

The Therapeutic Potential of Inflamed Gingiva-Derived Mesenchymal Stem Cells in Preclinical Studies: A Scoping Review of a Unique Biomedical Waste

Al-Qadhi

Al-Rai

Hafed

2021

Stem Cells International

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“…Interestingly, Fujii S et al found that BMSC-derived EVs ameliorated GVHD via suppressing the differentiation of naive T cell populations ( Fujii et al, 2018 ). Macrophages are crucial members of the innate immune response and can be regulated by MSC-exosomes in various diseases ( Zhao et al, 2018a ; Liu et al, 2019b ; Wang et al, 2019c ). Depending on the different microenvironment, naive macrophages (M0) can be polarized into pro-inflammatory M1 or anti-inflammatory M2 and play different roles in these conditions ( Shapouri-Moghaddam et al, 2018 ).…”

Section: Msc-exosomesmentioning

confidence: 99%

“…Depending on the different microenvironment, naive macrophages (M0) can be polarized into pro-inflammatory M1 or anti-inflammatory M2 and play different roles in these conditions ( Shapouri-Moghaddam et al, 2018 ). Wang R et al demonstrate that gingiva MSC-derived exosomes (GMSC-exosomes) might promote the conversion of M1 into M2 macrophages and reduce the pro-inflammatory factors produced by M1 macrophages ( Wang et al, 2019c ). Similarly, BMSC- ( Liu et al, 2019b ) and AMSC-exosomes ( Zhao et al, 2018a ) obtained consistent results.…”

Section: Msc-exosomesmentioning

confidence: 99%

Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine

et al. 2021

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As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular, exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in the diagnosis, prevention, and treatment of many diseases. In addition, through the combination of nanotechnology and biotechnology, exosomes have emerged as innovative tools for the development of nanomedicine. This review focuses on a profound summarization of MSC-exosomes as a powerful tool in bionanomedicine. It systemically summarizes the role of MSC-exosomes as a nanocarrier, drug loading and tissue engineering, and their potential contribution in a series of diseases as well as the advantages of exosomes over stem cells and synthetic nanoparticles and potential disadvantages. The in-depth understanding of the functions and mechanisms of exosomes provides insights into the basic research and clinical transformation in the field of nanomedicine.

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“…Macrophages express high levels of TLR2 and TLR4 [26], which shift to the M1 phenotype in gingival tissues of patients with chronic periodontitis [27]. Interestingly, M1 macrophages can transform into M2 macrophages by exosomes derived from gingival mesenchymal stem cells, which is beneficial for suppressing the immune responses [28].…”

Section: Macrophages In Periodontitismentioning

confidence: 99%

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Periodontitis is an infectious disease whereby the chronic inflammatory process of the periodontium stimulated by bacterial products induces specific host cell responses. The activation of the host cell immune system upregulates the production of inflammatory mediators, comprising cytokines and proteolytic enzymes, which contribute to inflammation and bone destruction. It has been well known that periodontitis is related to systemic inflammation which links to numerous systemic diseases, including diabetes and arteriosclerosis. Furthermore, periodontitis has been reported in association with neurodegenerative diseases such as Alzheimer’s disease (AD) in the brain. Regarding immune responses and inflammation, cathepsin B (CatB) plays pivotal role for the induction of IL-1β, cathepsin K- (CatK-) dependent active toll-like receptor 9 (TLR9) signaling, and cathepsin S (CatS) which involves in regulating both TLR signaling and maturation of the MHC class II complex. Notably, both the production and proteolytic activities of cathepsins are upregulated in chronic inflammatory diseases, including periodontitis. In the present review, we focus on the roles of cathepsins in the innate and adaptive immune responses within periodontitis. We believe that understanding the roles of cathepsins in the immune responses in periodontitis would help to elucidate the therapeutic strategies of periodontitis, thus benefit for reduction of systemic diseases as well as neurodegenerative diseases in the global aging society.

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Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions

Cited by 61 publications

References 66 publications

The Therapeutic Potential of Inflamed Gingiva-Derived Mesenchymal Stem Cells in Preclinical Studies: A Scoping Review of a Unique Biomedical Waste

The Therapeutic Potential of Inflamed Gingiva-Derived Mesenchymal Stem Cells in Preclinical Studies: A Scoping Review of a Unique Biomedical Waste

Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

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