Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients

Inaba, Masaaki; Okuno, Senji; Imanishi, Yasuo; Yamada, Shinsuke; Shioi, Atsushi; Yamakawa, Tomoyuki; Ishimura, Eiji; Nishizawà, Yoshiki

doi:10.1007/s00198-006-0154-6

Cited by 101 publications

(90 citation statements)

References 32 publications

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“…However, both clinical and basic studies have demonstrated conflicting evidence as to whether FGF-23 imparts a protective or a harmful role on vasculature under stress. [11][12][13][14][15] Recent studies have implicated reduced Klotho tissue levels as a cause of FGF-23 resistance at the parathyroid gland in CKD rats. 16,17 Whether vascular resistance to FGF-23 occurs in CKD that could mask its effects on the vasculature is an important question that needs addressing.…”

Section: Editorial See P 2181 Clinical Perspective On P 2255mentioning

confidence: 99%

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

et al. 2012

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Section: Editorial See P 2181 Clinical Perspective On P 2255mentioning

confidence: 99%

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

et al. 2012

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“…The diagnosis of diabetes was based on a history of diabetes or on the criteria in the Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (14). The inclusion of patients with type 1 diabetes was negated by a history of diabetes, because of the very small number of patients with type 1 diabetic in Japan (15,16). Patients with diabetes were restricted to those whose diabetes treatment had not been altered during the preceding 6 mo before the determination of GA and HbA 1c .…”

Section: Patientsmentioning

confidence: 99%

“…Blood was drawn immediately without overnight fasting, before the morning Monday/Tuesday session of HD, to measure serum parameters in HD patients, as described previously (15,16). In patients with diabetes and without CRF, blood samples were collected in the morning.…”

Section: Biochemical Measurementsmentioning

confidence: 99%

Glycated Albumin Is a Better Glycemic Indicator than Glycated Hemoglobin Values in Hemodialysis Patients with Diabetes

Inaba¹,

Okuno²,

Kumeda³

et al. 2007

Journal of the American Society of Nephrology

466

415

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The significance of glycated albumin (GA), compared with casual plasma glucose (PG) and glycated hemoglobin (HbA 1c ), was evaluated as an indicator of the glycemic control state in hemodialysis (HD) patients with diabetes. The mean PG, GA, and HbA 1c levels were 164.5 ؎ 55.7 mg/dl, 22.5 ؎ 7.5%, and 5.85 ؎ 1.26%, respectively, in HD patients with diabetes (n ‫؍‬ 538), which were increased by 51.5, 31.6, and 17.7%, respectively, compared with HD patients without diabetes (n ‫؍‬ 828). HbA 1c levels were significantly lower than simultaneous PG and GA values in those patients in comparison with the relationship among the three parameters in patients who had diabetes without renal dysfunction (n ‫؍‬ 365), as reflected by the significantly more shallow slope of regression line between HbA 1c and PG or GA. A significant negative correlation was found between GA and serum albumin (r ‫؍‬ ؊0.131, P ‫؍‬ 0.002) in HD patients with diabetes, whereas HbA 1c correlated positively and negatively with hemoglobin (r ‫؍‬ 0.090, P ‫؍‬ 0.036) and weekly dose of erythropoietin injection (r ‫؍‬ ؊0.159, P < 0.001), respectively. Although PG and GA did not differ significantly between HD patients with diabetes and with and without erythropoietin injection, HbA 1c levels were significantly higher in patients without erythropoietin. Categorization of glycemic control into arbitrary quartile by HbA 1c level led to better glycemic control in a significantly higher proportions of HD patients with diabetes than those assessed by GA. Multiple regression analysis demonstrated that the weekly dose of erythropoietin, in addition to PG, emerged as an independent factor associated with HbA 1c in HD patients with diabetes, although PG but not albumin was an independent factor associated with GA. In summary, it is suggested that GA provides a significantly better measure to estimate glycemic control in HD patients with diabetes and that the assessment of glycemic control by HbA 1c in these patients might lead to underestimation likely as a result of the increasing proportion of young erythrocyte by the use of erythropoietin.

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“…Shimada menunjukkan Fibroblast Growth Factor-23 dapat menekan ekspresi ginjal dari enzim 1a-hidroksilase dengan mengubah metabolit vitamin D ke dalam bentuk aktif (Shimada T et al, 2004). Fibroblast Growth Factor-23 dapat mengurangi kalsifikasi dengan menghambat aktivitas vitamin D. Inaba baru-baru ini melaporkan bahwa Fibroblast Growth Factor-23 merupakan faktor independen yang berhubungan dengan kalsifikasi pada arteri, tetapi tidak pada aorta pada pasien yang menjalani hemodialisis (Inaba et al, 2006).…”

Section: Hasil Dan Pembahasanunclassified

Pengaruh Pemberian 1,25 Dihydroxyvitamin D (Calcitriol) Terhadap Kadar Fibroblast Growth Factor-23 Dan Albuminuria Pada Pasien Penyakit Ginjal Kronik Stadium v Yang Menjalani Hemodialisis

Herlina¹,

Purwanto²,

Sugiarto³

2017

Biomedika

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Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients

Cited by 101 publications

References 32 publications

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23

Glycated Albumin Is a Better Glycemic Indicator than Glycated Hemoglobin Values in Hemodialysis Patients with Diabetes

Pengaruh Pemberian 1,25 Dihydroxyvitamin D (Calcitriol) Terhadap Kadar Fibroblast Growth Factor-23 Dan Albuminuria Pada Pasien Penyakit Ginjal Kronik Stadium v Yang Menjalani Hemodialisis

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