Role of endothelial miR-24 in COVID-19 cerebrovascular events

Gambardella, Jessica; Coppola, Antonietta; Izzo, Raffaele; Fiorentino, Giuseppe; Trimarcö, Bruno; Santulli, Gaetano

doi:10.1186/s13054-021-03731-1

Cited by 43 publications

(26 citation statements)

References 6 publications

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“…We extracted microRNAs using the miRVana miRNA isolation kit (Thermo Fisher Scientific, Waltham, MA) according to the manufacturer's protocol; the quality of miRNA was determined using Agilent Small RNA Kit (Matarese et al, 2020;Mone et al, 2021). A custom panel of mitochondrial related miRNAs was quantified as we previously described (Gambardella et al, 2021).…”

Section: Blood Collection and Circulating Mirnas Determinationmentioning

confidence: 99%

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Gambardella

Fiordelisi

Sorriento

et al. 2022

J Pharmacol Exp Ther

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We demonstrate for the first time that a specific signature of circulating mitochondrial microRNAs (mitomiRs) is dysregulated in Fabry disease (FD). In our study, we observed that mitomiRs regulating fundamental aspects of mitochondrial homeostasis and fitness, including expression and assembly of the respiratory chain, mitogenesis, antioxidant capacity, and apoptosis are significantly dysregulated in FD patients. Taken together, our new findings introduce mitomiRs as unprecedented biomarkers of FD and point at mitochondrial dysfunction as a novel potential mechanistic target for therapeutic approaches.

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Section: Blood Collection and Circulating Mirnas Determinationmentioning

confidence: 99%

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Gambardella

Fiordelisi

Sorriento

et al. 2022

J Pharmacol Exp Ther

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“…The non-optimal circular levels of some of these miRNAs such as miR-223, miR-93, miR-186, miR-18a (reduced), and miR-19a/b-3p as well as miR-15b (elevated) have been found in patients with the COVID-19 [170] , [171] , [174] , [176] , [197] . Decreased levels of miR-24 in ECs-derived extracellular vesicles (EVs) accompanied by more cerebrovascular complications have been reported in these patients [206] . The downregulation of miR-34a and miR-29b-3p was also reported in the post-mortem lung biopsy of patients with the severe COVID-19 [163] .…”

Section: Mirnasmentioning

confidence: 99%

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

Mortazavi-Jahromi

Aslani

2022

International Immunopharmacology

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“…Gambardella et al have reported a significant association level of miR-24 in endothelial cells/extracellular vesicles and cerebrovascular disorders, suggesting a possible mechanism for pathoetiology of cerebrovascular complications in COVID-19 ( Gambardella et al, 2021b ).…”

Section: Dysregulated Mirnas In Covid-19mentioning

confidence: 99%

“… ( Jafarinejad-Farsangi et al, 2020 ) miR-24 In vivo Patients hospitalized for COVID-19 369 plasma EC-EV miR-24 is associated with cerebrovascular complications in COVID-19. ( Gambardella et al, 2021a ) hsa-miR-190a In vivo 50 hsa-let-7d, hsa-miR-17, hsa-miR-34b, hsa-miR-93, hsa-miR-200b, hsa-miR-200c, hsa-miR-223 expression levels were decreased and hsa-miR-190a and hsa-miR-203 increased in COVID-19 patients. ( Demiray et al, 2021 ) hsa-miR-340-3p, hsa-miR-652-3p, hsa-miR-4772-5p, hsa-miR-192-5p, and hsa-miR-1291 Bioinformatics Autophagy These miRNAs may be markers to forecast alterations in mild SARS-CoV-2 infection.…”

Section: Dysregulated Mirnas In Covid-19mentioning

confidence: 99%