Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis

Talero, Elena; Sánchez-Fidalgo, Susana; Villegas, Isabel; Lastra, Catalina Alarcón de la; Illanes, Matilde; Motilva, Virginia

doi:10.1002/ibd.21420

Cited by 40 publications

(40 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2, Table III). These data are in accordance with Talero et al (2011), who have recorded the highest production of TNF-α in mice experimentally induced with colorectal carcinoma. In addition, Kemik et al (2010) have stated that TNF-alpha was significantly increased in the serum of cachectic patients with colon cancer.…”

Section: Resultssupporting

confidence: 93%

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Hamed

Ahmed

Khaled

2011

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 93%

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Hamed

Ahmed

Khaled

2011

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

“…15 A certain degree of inflammation is expected to be present in tumors; 10,16 thus the analysis of CRP and iNOS demonstrated a significant increase in the gene expression of these inflammation-related molecules in tumors.…”

Section: Discussionmentioning

confidence: 99%

“…To better interpret these data, we decided to evaluate the gene expression of molecules that have been demonstrated to be increased in inflammatory bowel diseases, 16 such as CRP, iNOS and TNF-α. Whereas the gene expression of TNF-α was unchanged among the groups studied, CRP and iNOS were increased in both the tumors and the tumorfree areas with respect to the control.…”

Section: Ace and Ace2 Enzymatic Activity In Human Colon Adenocarcinommentioning

confidence: 99%

Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma

Bernardi

Zennaro

Palmisano

et al. 2011

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Introduction: A new arm of the renin-angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells. Materials and methods: Gene, protein expression and enzymatic activity of the main components of the RAS were determined on non-neoplastic colon mucosa as well as on the tumor mass and the mucosa taken 5 cm distant from it, both collected from patients with colon adenocarcinoma. Two different human colon cancer cell lines were treated with AngII and Ang1-7. Results: The novel finding of this study was that MasR was significantly upregulated in colon adenocarcinoma compared with non-neoplastic colon mucosa, which showed little or no expression of it. ACE gene expression and enzymatic activity were also increased in the tumors. However, AngII and Ang1-7 did not have any pro-/antiproliferative effects in the cell lines studied. Conclusions:The data suggest that upregulation of the MasR could be used as a diagnostic marker of colon adenocarcinoma.

show abstract

“…In this regard, COX-2 activation produces excessive PGE 2 and TXB 2 , which are important inflammatory mediators that contribute to the intestinal hyperemia, edema and even dysfunction, and iNOS activation leads to excessive production of NO which may be detrimental to the integrity of the colon based on the generation of reactive nitrogen species causing cellular degeneration in various tissues and contributing to the development of intestinal damage [42]. Additionally, iNOS acts in synergy with COX-2 to promote the inflammatory reaction [43,44].…”

Section: Page 15 Of 37mentioning

confidence: 99%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

149

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

show abstract

Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis

Abstract: Our results show an early induction of proinflammatory factors, which may contribute to the development of colon cancer, as well as demonstrate, for the first time, the expression of AM in IBD-derived CRC.

Cited by 40 publications

References 77 publications

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Characterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Contact Info

Product

Resources

About