Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Abstract

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Protective effect of the essential oil of Zanthoxylum myriacanthum var. pubescens against dextran sulfate sodium-induced intestinal inflammation in mice

“…It is well accepted that the NF-κB pathway plays an important role in the maturation of UC ( Wong and Tergaonkar, 2009 ) and the inflammation process, and has been developed as a target for seeking anti-inflammatory agents from natural products. For example, ellagic acid and curcumin, which are naturally occurring plant phenols, exhibited anti-inflammatory activity through NF-κB signaling pathway by preventing I κB degradation and inducing an inhibition of the nuclear translocation of p65 ( Kim et al, 2005;Rosillo et al, 2011 ). In THP-1 cells, MQEO (v/v, 0.01 ‰ −0.05 ‰ ) effectively prevented the LPS-stimulated increase in TLR4 expression and markedly blocked the downstream I κB kinase (IKK) and I κB phosphorylation.…”

Protective effects of ellagic acid in d-galactosamine-induced kidney damage in rats

“…The kidneys were removed and washed with ice-cold 0.9 % NaCl. The dose and administration period have been selected corresponding to the previous studies (Rosillo et al 2011;Shi et al 2008;Zhou et al 2008).…”

The Use of Pomegranate (Punica granatum L.) Phenolic Compounds as Potential Natural Prevention Against IBDs

“…EA decreased COX-2 and iNOS protein expressions induced by TNBS. EA also inhibited both MAPK (ERK, JNK, and p38) pathways by preventing their phosphorylation and NF-κB pathway by preventing the IκBα degradation and the nuclear translocation of p65 in the intestinal epithelial cells from inflamed rat colon (Rosillo et al, 2011).…”

“…Among the in vivo studies on the effects of pomegranate PCs on intestinal inflammation related to IBDs, four studies conducted on murine models were reported in the literature: three with rats (Larrosa et al, 2010;Ogawa et al, 2002;Rosillo et al, 2011) and one with mice (Singh et al, 2009). Experimental models of IBD were induced by a daily oral administration of dextran sulphate sodium (DSS) at 2-5% (v/v) in drinking water or by intra-colonic administration of trinitrobenzene sulfonic acid (TNBS).…”