2011
DOI: 10.1590/s0074-02762011000300011
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Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

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Cited by 8 publications
(4 citation statements)
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“…The variation in plasma and tissue results can be explained by induced tissue damage in the infection period, led to the release of enzyme from the necrotic tissue to blood stream or due to the increased cell anoxia and irritation by toxic or metabolic products of the worm as reported by Ahmed and Gad (1995); Hamed et al (2011). In accordance to results herein Thangaraju et al (2009);Metwally et al (2011) reported that elevation of LDH activity in malignant and bilharzial colonic carcinoma can be used as an indicator for the stimulation of anaerobic pathways in cases of abnormal growth of human cancer cells.…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…The variation in plasma and tissue results can be explained by induced tissue damage in the infection period, led to the release of enzyme from the necrotic tissue to blood stream or due to the increased cell anoxia and irritation by toxic or metabolic products of the worm as reported by Ahmed and Gad (1995); Hamed et al (2011). In accordance to results herein Thangaraju et al (2009);Metwally et al (2011) reported that elevation of LDH activity in malignant and bilharzial colonic carcinoma can be used as an indicator for the stimulation of anaerobic pathways in cases of abnormal growth of human cancer cells.…”
Section: Discussionmentioning
confidence: 95%
“…In general, constitutive exposure to high levels of pro-inflammatory cytokines is thought to be protumorigenic. Hamed et al (2011) reported that blood level of TNF-α was higher in colonic carcinoma associated with schistosomal infection than colonic carcinoma without schistosomal infection. These data are in accordance with Talero et al (2011) who had recorded the highest production of TNF-α in mice experimentally induced colorectal cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Also, inflammation also exacerbates the development of liver injury. Nuclear factor-kappa B (NF-κB), an inducible transcription factor with pleiotropic functions, is critically involved in the occurrence and development of inflammation which actively participates in the transcription of many pro-inflammatory factors, including interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) [17] , [18] . However, the exact relationship between Cr(VI)-induced liver injury and inflammation, as well as apoptosis has not yet been elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…Other helminth-derived molecules are unique to the parasites and help them initiate tissue damage and establish infection (Periago and Bethony, 2012;Flynn et al, 2019). Such helminth-specific biomolecules have also been explored widely as biomarkers for developing diagnostics and targets for developing vaccines and drugs (Hamed et al, 2011;Ryan et al, 2020;Whitman et al, 2021). Numerous reviews (McSorley et al, 2013;Maizels and McSorley, 2016;Maizels et al, 2018;Zakeri et al, 2018;Ryan et al, 2020) have substantially discussed the nature and functions of many helminth-derived macromolecules, including secreted proteins, peptides, and extracellular vesicles.…”
Section: Introductionmentioning
confidence: 99%