2014
DOI: 10.7314/apjcp.2014.15.3.1125
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Abstract: Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted u… Show more

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Cited by 12 publications
(12 citation statements)
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References 47 publications
(44 reference statements)
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“…These results confirm some previously reported data and report new IgG glycomic alterations that associate with HIV infection and persist despite suppressive ART. In particular, decreased levels of IgG sialylated glycans, which is associated with proinflammatory activity, and increased levels of IgG fucosylated glycans, which is associated with lower ADCC and higher inflammation, regardless of the ART‐suppression status.…”
Section: Resultsmentioning
confidence: 99%
“…These results confirm some previously reported data and report new IgG glycomic alterations that associate with HIV infection and persist despite suppressive ART. In particular, decreased levels of IgG sialylated glycans, which is associated with proinflammatory activity, and increased levels of IgG fucosylated glycans, which is associated with lower ADCC and higher inflammation, regardless of the ART‐suppression status.…”
Section: Resultsmentioning
confidence: 99%
“…(Gabay et al, 1999;Mantovani et al, 2008;Yildirim et al, 2013). In several studies, high inflammatory parameters (CRP, alpha and gamma globulins, neutrophil lymphocyte ratio (NLR), complement C3-C4) were found and associated with reduced overall survival in patients with different cancers including lung cancers (Shimada et al, 2003;Canna et al, 2005;Kaya et al, 2013;Zheng et al, 2013;Dai et al, 2014;Soliman et al, 2014). Increasing synthesis of acute phase proteins and interleukins and tumor necrosis-related hypoxia may be the mechanisms underlying this increased inflammation (McMillan et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, the hypoxia participates in the induction of tumor angiogenesis and promotes cancer (Barrera, 2012;Fiaschi and Chiarugi, 2012;Sosa et al, 2013). Studies have shown that oxidative stress affects several signaling pathways associated with cell proliferation (Soliman et al, 2014). Among them the epidermal growth factor receptor signaling pathway (EGFR) can be mentioned, in which proteins such as the nuclear factor erythroid 2-related factor2 (Nrf2) and Raf are involved.…”
Section: Oxidative Stress and Cancermentioning
confidence: 99%