Role of Dietary Flavonoids in Iron Homeostasis

Lesjak, Marija; Srai, Surjit Kaila

doi:10.3390/ph12030119

Cited by 38 publications

(29 citation statements)

References 107 publications

(130 reference statements)

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“…Quercetin's role in iron absorption, however, is still debatable as quercetin reduces ferroportin activity and, consequently, iron efflux to the bloodstream. This, in turn, induces an accumulation of quercetin-iron complexes in the mucosa that are lost daily by mucosal exfoliation [111,112]. Many iron chelators show anti-inflammatory activities because they can deprive immune cells of iron as well as block its uptake by invading bacteria.…”

Section: Nutritional Sources That Hinder Iron Absorptionmentioning

confidence: 99%

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

et al. 2021

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Iron deficiency (ID) affects people of all ages in many countries. Due to intestinal blood loss and reduced iron absorption, ID is a threat to IBD patients, women, and children the most. Current therapies can efficiently recover normal serum transferrin saturation and hemoglobin concentration but may cause several side effects, including intestinal inflammation. ID patients may benefit from innovative nutritional supplements that may satisfy iron needs without side effects. There is a growing interest in new iron-rich superfoods, like algae and mushrooms, which combine antioxidant and anti-inflammatory properties with iron richness.

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Section: Nutritional Sources That Hinder Iron Absorptionmentioning

confidence: 99%

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

et al. 2021

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“…Granado-Serrano et al (2012) demonstrated that quercetin can activate the Nrf2 pathway by supporting nuclear translocation and its transcriptional activity [ 95 ]. Given that the levels of ferroportin (FPN) and ferritin are overexpressed transcriptionally by the Nrf2 pathway, quercetin could affect iron homeostasis and help cells to fight against oxidative stress [ 96 ]. Prenatal exposure of mice to quercetin resulted in increased hepatic iron deposits and induced overexpression of hepcidin to adults [ 77 ].…”

Section: Natural Antioxidants In Iron Overload Treatmentmentioning

confidence: 99%

“…However, the precise site of iron chelation by quercetin is unknown. It is not known whether chelation occurs in the duodenal lumen or in the cytosol of duodenal enterocytes [ 96 ].…”

Section: Natural Antioxidants In Iron Overload Treatmentmentioning

confidence: 99%

Natural Antioxidants in Anemia Treatment

Cotoraci

Ciceu

Sasu

2021

IJMS

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Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

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“…However, it should be noted that dietary iron is present in two chemical forms—as heme and nonheme—which differ in their bioavailability and uptake [ 24 ]. Heme iron, derived from animal products, is absorbed up to 25–35% [ 25 ], whereas nonheme iron, derived from both animal and plant products [ 26 ], is absorbed much less, in the range of 2–20% [ 27 ]. The greater efficiency of absorption of heme iron results from specific transporters that allow it to pass directly across cell membranes and into the bloodstream, while these transporters cannot be utilized by nonheme iron and require ferric iron (Fe 3+ ) to be reduced to ferrous iron (Fe 2+ ) prior to absorption [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Environmental Determinants of Heme and Nonheme Iron Intake in a National Sample of Polish Adolescents

Skolmowska

Głąbska

2021

IJERPH

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Intake of sufficient amounts of iron by adolescents is a matter of great concern. Therefore, it is crucial to determine the factors that may influence iron intake in this specific population. The present study aimed to analyze the environmental determinants of the intake of heme and nonheme iron in a national homogenous sample of Polish adolescents. Adolescents (aged 15–20 years) were randomly chosen from all the regions of Poland by performing a sampling of secondary schools (random quota sampling). The total iron intake, as well as the intake of heme iron, nonheme iron, animal iron, plant iron, and iron from various food products, was assessed among 1,385 female respondents and 1,025 male respondents using the validated IRON Intake Calculation—Food Frequency Questionnaire (IRONIC-FFQ). The intake was compared between the subgroups stratified by meat intake in the region, gross domestic product (GDP) in the region, and size of the city (rural vs. urban environment). It was observed that meat intake in the region did not influence the intake of total iron, as well as the intake of heme iron, nonheme iron, animal iron, plant iron, and iron from various food products (p > 0.05). However, GDP and the size of the city were determined as the most influencing factors, as they were associated with iron intake in both female and male adolescents, with the most prominent differences between the subgroups found in the case of females. Female adolescents from high-GDP regions had significantly higher intake of heme iron (p = 0.0047) and animal iron (p = 0.0029), and lower intake of nonheme iron compared to those from low-GDP regions (p = 0.0342). The total iron intake was higher among female adolescents who were from medium cities than those from big cities (p = 0.0350), but significantly higher animal iron intake (p = 0.0404) and plant iron intake (p = 0.0385) were observed among females from villages and small towns compared to females from other groups. Based on the results, it may be concluded that size of the city and the economic status of the region are the most important environmental determinants of iron intake in adolescents and, hence, they should be taken into account while developing educational programs, especially for the female adolescent population.

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Role of Dietary Flavonoids in Iron Homeostasis

Cited by 38 publications

References 107 publications

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

Natural Antioxidants in Anemia Treatment

Analysis of Environmental Determinants of Heme and Nonheme Iron Intake in a National Sample of Polish Adolescents

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