Natural Antioxidants in Anemia Treatment

Abstract

Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

Benefits of Fermented Papaya in Human Health

“…Furthermore, the researchers studied FPP ® in vivo effect in thalassemic mice and observed that treatment with FPP ® significantly reduced all tested oxidative stress parameters. Finally, they studied the FPP ® effect in patients, and like the results obtained in vitro, these results showed a significant reduction in all oxidative stress parameters tested in blood cells [ 48 ]. Another study conducted by some authors of the previous study investigated the effect of oral supplementation with FPP ® in oxidative status of two groups of thalassemia patients: β-thalassemia major and intermedia (in Israel) and E-β-thalassemia (in Singapore).…”

Derivatives of 3-Hydroxypyridine in The Correction of Disorders in The Structural and Functional Properties of Erythrocytes in Experimental Acute Destructive Pancreatitis Due to Chronic Ethanol Intoxication

“…When assessing the parameters of erythrocytes metabolism, it has been established that in presence of ADP and CAI, the concentration of LPO products (MDA, AHP) in the red blood cells increases, the activity of catalase, SOD, the level of SMNO and the sorption parameters of erythrocyte membrane (SCE and SCG) decrease. The introduction of ethoxidol brings all the studied parameters of erythrocytes closer to the control values 2,9,14 . The use of mexidol additionally normalizes the activity of catalase and increases, but not to the parameters of the norm, the concentration of SMNO.…”

Toxicity Studies on Essential Oil from Phoenix dactylifera (L.) Seed in Wistar Rats

“…The general dose-dependent increase in levels of PCV, RBC and HB in the test groups could be as a result of PDEO having hematopoietic potential to stimulate erythropoietin release from the kidneys, which is the humoral regulator of RBC production [33,34]. Plant extracts that exert this property could serve as good blood supplements and may be used to cure anemia [35]. Erythropoietin release also has beneficial effect on non-hematopoietic tissues due to its anti-apoptotic, anti-inflammatory, and antioxidant properties which confers neuro and cardioprotection [36].…”