Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

Verna, Giulio; Sila, Annamaria; Liso, Marina; Mastronardi, Mauro; Chieppa, Marcello; Cena, Hellas; Campiglia, Pietro

doi:10.3390/nu13020378

Cited by 17 publications

(10 citation statements)

References 202 publications

(215 reference statements)

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“…It is essential to look at different approaches to improve Fe contents and bioavailability from fortified foods. It seems promising to study the interactions between individual nutrients added to the medium in search of favourable intake and synergistic effects [39]. In our experiment, we added 5 and 10 mM of Ca (which correspond to 200 and 400 mg L −1 Ca) as a modulating factor for Fe accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Although we could not find any literature data on similar mushroom supplementation of Fe with the addition of Ca, we can try to find common conclusions from the coincident supplementation of other elements. Scheid et al [39] explored Fe biofortification and availability of fortification Lentinus crinitus, G. lucidum, S. commune, P. ostreatus, P. eryngii and Lentinula edodes. Mushrooms were grown on malt-extract or sugarcane molasses with different concentrations of Fe (0.116 and 91.23 mg L −1 , respectively) as well as Mg (260.0 and 903.1 µg L −1 , respectively).…”

Section: Discussionmentioning

confidence: 99%

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Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Budzyńska

Siwulski

Magdziak

et al. 2021

Plants

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Mushrooms supplementation with iron (Fe) is usually limited, and therefore it would be beneficial to search for other vital elements able to improve the process. The aim of this study was to verify a possible interaction between Fe and calcium (Ca) to estimate the role of the addition of the latter metal to stimulate Fe accumulation in Pholiota nameko. Additionally, an analysis of phenolic compounds and low molecular weight organic acids (LMWOAs) was performed. The increase of Fe concentration in the substrate caused a significantly higher accumulation of this metal in P. nameko. The addition of Ca (5 or 10 mM) stimulated Fe accumulation, just as Fe concentration in the substrate stimulated Ca accumulation, which pointed to a synergism between these metals. The obtained results show that the presence of Fe in the substrate may also promote K, Mg, Mn, Na, P, and S accumulation. In contrast, the addition of Ca stimulates and/or inhibits their content in fruit bodies. The phenolic and organic acids profile was poor. Only gallic, 4-hydroxybenzoic, sinapic and syringic acids (phenolics), as well as citric and succinic acids (LMWOAs), were quantified in some combinations in P. nameko fruiting bodies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Budzyńska

Siwulski

Magdziak

et al. 2021

Plants

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“…One attractive candidate is maternal choline supplementation. Choline is an essential nutrient that is critically involved in early brain development [22,23], and is readily found in over 630 food sources [24], which makes it more accessible than iron [25]. Choline supplementation during specific pre-and postnatal time windows reverses some cognitive deficits observed in a rodent model of fetal-neonatal ID associated with increased expression of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) [21,26,27].…”

Section: Introductionmentioning

confidence: 99%

Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate Jarid1b and Bdnf in the Rat Hippocampus into Adulthood

et al. 2021

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Early-life iron deficiency (ID) causes long-term neurocognitive impairments and gene dysregulation that can be partially mitigated by prenatal choline supplementation. The long-term gene dysregulation is hypothesized to underlie cognitive dysfunction. However, mechanisms by which iron and choline mediate long-term gene dysregulation remain unknown. In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB). Likewise, ID reduced transcriptional capacity of the gene encoding brain-derived neurotrophic factor (BDNF), a target of JARID1B, associated with repressive histone modifications such as lower H3K9ac and pCREB enrichments at the Bdnf promoters in the adult rat hippocampus. Prenatal choline supplementation did not prevent the ID-induced chromatin modifications at these loci but induced long-lasting repressive chromatin modifications in the iron-sufficient adult rats. Collectively, these findings demonstrated that the iron-dependent epigenetic mechanism mediated by JARID1B accounted for long-term Bdnf dysregulation by early-life ID. Choline supplementation utilized a separate mechanism to rescue the effect of ID on neural gene regulation. The negative epigenetic effects of choline supplementation in the iron-sufficient rat hippocampus necessitate additional investigations prior to its use as an adjunctive therapeutic agent.

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“…Based on our previous studies, demonstrating quercetin’s ability to suppress several pathways of the mDCs inflammatory response, in the present study, we focused our attention on the potential anti-inflammatory and antioxidant effects of pDCs exposure to quercetin. Quercetin is present in many foods (groceries and fruits) that are often called “superfoods” [ 22 ]. Together with several other groups, we demonstrated that quercetin could prevent bone marrow-derived DCs (BMDCs) inflammatory response to LPS administration, and, at the same time, promote tissue repair both in vivo and in vitro [ 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

Verna

Liso

Cavalcanti

et al. 2021

IJMS

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Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).

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Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

Cited by 17 publications

References 202 publications

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate Jarid1b and Bdnf in the Rat Hippocampus into Adulthood

Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

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