Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice

Woo, Shin Sang; Lee, Hu Jang; Cho, Myung‐Haing; Lee, Mun Han; Koh, Won‐Gun; Han, Sangsoo; Kim, Jung-Ae; Lee, Eung-Seok; Nam, Doo-Hyun; Jeong, Tae Cheon

doi:10.1016/s0378-4274(00)00306-4

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…Thus, it is possible to assume that the lower feed intake, and consequent body weight reductions, that were observed in mice that were treated with urethane (the U, PSU and PU groups) (data not shown) were due to its anesthetic action since the mice required 60 min or more to become active after the application of this carcinogen. Urethane has also been reported to have immunosuppressive properties, causing reductions in different types of immune cells, such as B lymphocytes, T helper and T cytotoxic lymphocytes, and macrophages in the spleen of BALB/c mice 33 . Conversely, selenium supplementation was shown to modulate the activation and differentiation of T helper lymphocytes into Th1 cells in C57BL/6 mice 34 , and was also shown to increase NK cell-mediated cytotoxicity 35 .…”

Section: Discussionmentioning

confidence: 99%

Effects of selenium onPteridium aquilinumand urethane-induced lung carcinogenesis

Nakahara

Sanches

Caniceiro

et al. 2013

Immunopharmacology and Immunotoxicology

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The results of our previous study demonstrated that ptaquiloside, the main toxic agent found in Pteridium aquilinum, suppresses natural killer (NK) cell-mediated cytotoxicity. However, the ability of ptaquiloside to suppress the cytotoxicity of NK cells was prevented by selenium supplementation. NK cells play an important role in the innate immune response and have the ability to kill tumor cells. Therefore, we hypothesized that selenium may prevent the higher susceptibility to urethane-induced lung carcinogenesis that has been observed in mice treated with P. aquilinum. The immunosuppressive effects of ptaquiloside have been associated with a higher number of urethane-induced lung nodules in mice. Hence, we assessed the effects of P. aquilinum-induced immunosuppression on urethane-induced lung carcinogenesis in C57BL/6 mice that had been supplemented with selenium. For these experiments, mice were treated with both an aqueous extract of P. aquilinum (20 g/kg/day) and selenium (1.3 mg/kg) by gavage once daily for 14 days followed by a once-weekly intraperitoneal injection of urethane (1 g/kg) for 10 weeks that was accompanied by gavage 5 days a week. Lung adenomas in mice that had been treated with P. aquilinum plus urethane occurred with a frequency that was 44% higher than that in mice that had been treated with only urethane. In mice that had been supplemented with selenium and treated with P. aquilinum plus urethane, the occurrence of lung adenomas was reduced to 26%. These results suggest that selenium prevents the immunosuppressive effects of P. aquilinum on urethane-induced lung carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Effects of selenium onPteridium aquilinumand urethane-induced lung carcinogenesis

Nakahara

Sanches

Caniceiro

et al. 2013

Immunopharmacology and Immunotoxicology

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“…In our model Urethane injection was associated with nodules from 413.5 to 9091.3 µm 2 and positive expression for PCNA. Moreover, Cha et al [16] evaluated BALB/c female mice 7 days after Urethane injection and observed a significant decrease in spleen cell number, expression of CD4, CD8, B cells and macrophages suggesting that this carcinogen promotes immunosuppression. In opposite, Stathopoulos et al [7] found in BALB/c mice after 1 week of Urethane administration the increase of circulating neutrophils and inflammatory cells in bronchoalveolar lavage (BAL) fluid besides of increased TNF-α and IL-12p70 levels.…”

Section: Discussionmentioning

confidence: 99%

Lung Tumor Development in the Presence of Sphingosine 1-phosphate Agonist FTY720

Salinas

Lopes

Palma³

et al. 2009

Pathol. Oncol. Res.

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Urethane is a chemical carcinogen which causes lung tumorigenesis in mice with similarities to human adenocarcinoma (AC). The sphingosine 1-phosphate agonist FTY720 administered to mice in doses above 5 mg/kg/day has been able to prevent hepatocellular carcinoma and bladder cancer. We used BALB/c mice in urethane-induced lung cancer model to investigate the effects of a lower dose of FTY720 (1 mg/kg/day). The benefits of FTY720 were associated with the time point of the compound administration. FTY720 30 Group presented lower incidence and smaller area of lung nodules, decreased PCNA and increased Caspase-3 expressions. The findings in FTY720 0 Group (nodule multiplicity and area, PCNA expression) were similar to Urethane Group suggesting that the administration of the compound at early time point did not affect lung tumor development. FTY720 90 Group presented the biggest nodule area which was associated with increased PCNA and decreased Caspase-3 expressions. FTY720 (30 days and 90 days) administration decreased CD4 + splenocytes and blood lymphocytes which caused opposite effects in lung tumor development - impairment and improvement respectively.In conclusion, FTY720 in low dose did not provide lung tumor inhibition in mice but its administration 30 days after the chemical carcinogen (Urethane) injection was associated with impaired tumor development.

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“…Carbofuran suppressed both humoral 47,48 and cellular immunity and inhibited the expression of complement activity when added to human serum 31 . Animals exposed to aldicarb or ethyl carbamate which is a suffered from lowered humoral immune response 49 . Several possible mechanisms may explain the inhibitory effects of carbosulfan on lymphocytes.…”

Section: Hematological and Immunological Toxicity Of Carbosulfanmentioning

confidence: 99%

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

Dhouib¹,

Abdeladhim²,

Lasram³

et al. 2014

IOSRJESTFT

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Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice

Cited by 12 publications

References 18 publications

Effects of selenium onPteridium aquilinumand urethane-induced lung carcinogenesis

Effects of selenium onPteridium aquilinumand urethane-induced lung carcinogenesis

Lung Tumor Development in the Presence of Sphingosine 1-phosphate Agonist FTY720

Assessment of the Toxic Potential of Carbosulfan in Rats Following Subchronic Treatment

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