Role of Coenzyme Q₁₀ in Chronic Heart Failure, Angina, and Hypertension

Abstract

Coenzyme Q10 therapy in angina and hypertension cannot be substantiated until additional clinical trials demonstrate consistent beneficial effects. However, CoQ10 may be recommended as adjuvant therapy in selected patients with CHE At this time, CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state.

Effect of Co-Administration of Coenzyme Q10 with Metformin on Diabetic Albino Rats

“…Coenzyme Q10 is a fat-soluble, vitamin-like quinone commonly known as ubiquinone, CoQ, and vitamin Q10 (Greenberg and Frishman, 1990;Tran et al, 2001). It is a ubiquitous compound vital to a number of activities related to energy metabolism and found in highest concentrations in tissues with high energy turnover such as the heart, brain, liver, and kidney.…”

Red Blood Cell Membrane Physiology In Atorvastatin Treated Rats As Evaluated By Osmofragility Test And Possible Protective Role of Coenzyme Q 10

“…Reduced CoQ 10 makes RBC prone to excessive oxidative damage and makes RBC vulnerable to hemolysis (4 -6). CoQ 10 is richly concentrated in the brain, heart, kidneys and liver (11,12). CoQ 10 helps mitochondria to extract energy and is a powerful antioxidant compound (13).Currently, use of HMG-co A reductase inhibitors (Atorvastatin), in routine clinical practice, is very common in Pakistan and many patients are receiving drug as part of cardiac drug therapy.…”

Comparative Study on the Influence of Epigallocatechin-3-gallat e and/ or Coenzyme Q10 against Alzheimer's disease Induced by Aluminium in Normally-Fed and Protein Malnourished Rats

“…Consequently, folic Acid is considered an essential cofactor for the endogenous synthesis of CoQ10 and any deficiency in folic acid would result in a deficiency in CoQ10 [30]. The efficacy of CoQ10 appears to be promising for alleviating neurodegenerative disorders [31]. It is worthy to note that CoQ10 is reduced in AD patients [32,33].…”