Effect of Co-Administration of Coenzyme Q10 with Metformin on Diabetic Albino Rats

Abstract

A b s t r a c t A r t i c l e I n f oHigh blood glucose concentration degenerates vital tissues and it is correlated with diabetes and its complications. It generates free radicals by metal catalyzed oxidation of glucose, oxidative degeneration and by protein glycation. Therefore chronic antioxidant therapy may be useful in preventing the degenerative changes by free radical scavenging nature. In this way it may have the positive impact in protecting the tissue from further damaging effect of hyperglycemia. On this background the plan of this research work was made. Two groups of six healthy male albino rats weighting 150-250 g were used in this experiment. Diabetes was induced by freshly prepared single intraperitoneal injection of streptozotocin in the dose of 60 mg/kg body weight pretreated with nicotinamide intraperitoneally in a dose of 120 mg/kg body weight. First group was treated with metformin 45 mg/kg body weight and the 2 nd group by metformin in the same dose and coenzyme Q10 1.8 mg/kg body weight concurrently once daily for 28 days. Fasting blood sugar was measured weekly till four weeks in morning hour. In the initial few weeks there was no difference in fasting blood sugar level but at the end of 4 week there was little more decrease in fasting blood sugar which was significant statistically. This shows that coenzyme Q10 have the positive impact in controlling the blood sugar level in mild diabetic rats probably due to its crucial antioxidant nature as add on drug with metformin.