Role of CD28/B7 co‐stimulation in airway T helper 2 (TH2) immune responses in asthma

Lordan, JL; Jaffar, ZH

doi:10.1046/j.1365-2222.1998.00424.x

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…There is increasing evidence that AR or asthma, chronic airway inflammatory diseases characterized by reversible airway obstruction, hyper‐reactivity and lymphocyte/eosinophil recruitment are driven and maintained by chronically activated T cells with a T‐helper 2 (Th2) phenotype. These T cells promote the activation and recruitment of B cells and regulate the Ig class switch to the development of antigen‐specific IgE responses [35–38]. We previously reported that a majority of the CD4 + T cells in the nasal mucosa of allergic rhinitics co‐expressed the CD45RO surface molecule, and a predominant proportion of CD4 + T cells in the nasal epithelium were CD45RO + (memory T cells) [39].…”

Section: Discussionmentioning

confidence: 99%

Increased expression of HLA‐DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up‐regulation by diesel exhaust particles

Takizawa¹,

Pawankar²,

Yamagishi³

et al. 2007

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Increased expression of HLA‐DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up‐regulation by diesel exhaust particles

Takizawa¹,

Pawankar²,

Yamagishi³

et al. 2007

Clin Experimental Allergy

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“…However, Vβ8a-positive cells are not identical with the IL-4 producers, since our measurements of intracellular cytokines reveal that IL-4 production does not increase in parallel with Vβ8a increase. The differentiation of cytokine-producing Th cells is influenced by antigen affinity for the T cell receptor as well as co-stimulation signals like CD28 and CD86 [30]. Tao et al [31]suggest that naive CD4 T cells are receptive to CD28-dependent IL-4 production only if they receive a weak T cell receptor signal.…”

Section: Discussionmentioning

confidence: 99%

Does IL-4 Play a Role in the Expansion of Vβ8a T Cell Receptor-Bearing Cells?

Liebers

Gellert²,

Raulf‐Heimsoth³

et al. 2001

Int Arch Allergy Immunol

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Background: Peripheral blood mononuclear cells (PBMC) of subjects allergic to the insect-derived allergen Chi t 1–9 are characterized by an allergen-induced pronounced proliferation and increased expression of activation markers (CD25, HLA-DR, CD23). T cell lines showed an elevated percentage of Vβ8a-positive cells following stimulation by Chi t 1–9. Objective: The aim of the present study was to investigate whether Vβ8a dominance plays an important role in PBMC short-term cultures (24 h) as well. The role of exogenous added cytokines, especially IL-4, has been determined. Methods: The T cell receptor repertoire was measured with 16 monoclonal antibodies to epitopes on the variable region of the β chain by flow cytometry. Patients allergic to Chi t 1–9 were compared to nonallergic subjects as well as to subjects with other occupational allergies. In addition, cytokines were determined intracellulary by flow cytometry. Studies were performed with PBMC cultured for 24 h. Results: After cultivation for 24 h without or with different stimuli (cytokines, allergen, phytohaemagglutinin), changes in the T cell receptor profile and the cytokine profile were measurable compared to the baseline value (without cultivation). Stimulation with IL-4 revealed increased percentages of Vβ8a-expressing cells in Chi t 1–9-sensitized patients. This IL-4-induced Vβ8a increase did not occur in PBMC from the two control subject groups (non-allergic and allergic to other allergens than Chi t 1–9). Conclusion: In conclusion, the dominance of certain T cell receptor types seems to arise due to the exposure to specific allergens and cytokine production. Some T cell receptors are often affected, for example Vβ8a, whereas others only show minor variations. Vβ8a expression obviously plays an important role in Chi t 1–9 allergy.

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Asthma: Clinical Aspects and Mucosal Immunology

Holgate

2005

Mucosal Immunology

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Role of CD28/B7 co‐stimulation in airway T helper 2 (TH2) immune responses in asthma

Cited by 4 publications

References 25 publications

Increased expression of HLA‐DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up‐regulation by diesel exhaust particles

Increased expression of HLA‐DR and CD86 in nasal epithelial cells in allergic rhinitics: antigen presentation to T cells and up‐regulation by diesel exhaust particles

Does IL-4 Play a Role in the Expansion of Vβ8a T Cell Receptor-Bearing Cells?

Asthma: Clinical Aspects and Mucosal Immunology

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