Role of Acute Myeloid Leukemia (AML)-Derived exosomes in tumor progression and survival

Amin, Ali H.; Sharifi, Liqaa Mohammed Al; Kakhharov, Alisher Jamoliddinovich; Opulencia, Maria Jade Catalan; Alsaikhan, Fahad; Bokov, Dmitry Olegovich; Majdi, Hasan Sh.; Jawad, Mohammed Abed; Hammid, Ali Thaeer; Shalaby, Mohammed Nader; Mustafa, Yasser Fakri; Siahmansouri, Homayoon

doi:10.1016/j.biopha.2022.113009

Cited by 23 publications

(22 citation statements)

References 117 publications

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“…Briefly, ExMVs can affect the proliferation and survival of leukemic cells, modulate the hematopoietic microenvironment to support leukemia cell expansion, contribute to immune escape by malignant cells, and promote chemotherapy resistance [ 12 , 24 – 27 , 30 , 31 ]. On the other hand, they could play a role in diagnosing hematopoietic malignancies as they express potential biomarkers and even be modified as drug carriers for therapy [ 22 , 32 – 34 ]. This will be discussed later in this review.…”

Section: Exmvs As Modulators Of Cell Functionmentioning

confidence: 99%

Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered

Ratajczak,

Ratajczak

2024

Leukemia

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In single-cell organisms, extracellular microvesicles (ExMVs) were one of the first cell-cell communication platforms that emerged very early during evolution. Multicellular organisms subsequently adapted this mechanism. Evidence indicates that all types of cells secrete these small circular structures surrounded by a lipid membrane that may be encrusted by ligands and receptors interacting with target cells and harboring inside a cargo comprising RNA species, proteins, bioactive lipids, signaling nucleotides, and even entire organelles “hijacked” from the cells of origin. ExMVs are secreted by normal cells and at higher levels by malignant cells, and there are some differences in their cargo. On the one hand, ExMVs secreted from malignant cells interact with cells in the microenvironment, and in return, they are exposed by a “two-way mechanism” to ExMVs secreted by non-leukemic cells. Therefore, leukemogenesis occurs and progresses in ExMVs enriched microenvironments, and this biological fact has pathologic, diagnostic, and therapeutic implications. We are still trying to decipher this intriguing cell-cell communication language better. We will present a current point of view on this topic and review some selected most recent discoveries and papers.

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Section: Exmvs As Modulators Of Cell Functionmentioning

confidence: 99%

Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered

Ratajczak,

Ratajczak

2024

Leukemia

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“…AML is a group of aggressive hematopoietic malignancies that arise from myeloid precursors ( 149 ). Although AML treatments have improved significantly in recent decades, relapses of AML and drug resistance are still the major challenges in the treatment of AML ( 150 ), with only 40% of young patients staying in remission at five years after treatment ( 151 , 152 ). Therefore, more accurate classification and diagnosis are needed.…”

Section: The Roles Of Raman Spectroscopy In Pediatric Cancermentioning

confidence: 99%

The emerging applications and advancements of Raman spectroscopy in pediatric cancers

Feng²,

Xu³

et al. 2023

Front. Oncol.

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Although the survival rate of pediatric cancer has significantly improved, it is still an important cause of death among children. New technologies have been developed to improve the diagnosis, treatment, and prognosis of pediatric cancers. Raman spectroscopy (RS) is a non-destructive analytical technique that uses different frequencies of scattering light to characterize biological specimens. It can provide information on biological components, activities, and molecular structures. This review summarizes studies on the potential of RS in pediatric cancers. Currently, studies on the application of RS in pediatric cancers mainly focus on early diagnosis, prognosis prediction, and treatment improvement. The results of these studies showed high accuracy and specificity. In addition, the combination of RS and deep learning is discussed as a future application of RS in pediatric cancer. Studies applying RS in pediatric cancer illustrated good prospects. This review collected and analyzed the potential clinical applications of RS in pediatric cancers.

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“…It is characterized by incomplete maturation of myeloid cells that occurs due to the clonal over-proliferation of an aberrant stem cell engaged at the level of colony forming unit (CFU) or later stages of differentiation. This situation leads to the accumulation and clonal expansion of non-functional myeloblasts, known as blasts, that accumulate in the BM and blood [27]. AML induces multipotent mesenchymal stem/stromal cells (MSC) to differentiate into adipocytes rather than osteoblasts, with a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS) during energy production.…”

Section: Acute Myeloid Leukemiamentioning

confidence: 99%

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

et al. 2022

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Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor microenvironment (TME), and have also been associated with communicating anti-cancer drug resistance (DR). The increase in proliferation of cancer cells alters oxygen levels, which causes hypoxia and results in a release of exosomes by the cancer cells. In this review, the results of studies examining the role of exosomal miRNA in DR, and their mechanism, are discussed in detail in hematological tumors: leukemia, lymphoma, and multiple myeloma. In conclusion, we underline the exosome’s function as a possible drug delivery vehicle by understanding its cargo. Engineered exosomes can be used to be more specific for personalized therapy.

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Role of Acute Myeloid Leukemia (AML)-Derived exosomes in tumor progression and survival

Cited by 23 publications

References 117 publications

Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered

Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered

The emerging applications and advancements of Raman spectroscopy in pediatric cancers

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

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