Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Cariello, Mariaconcetta; Squilla, Angela; Piacente, Martina; Venutolo, Giorgia; Fasano, Alessio

doi:10.3390/molecules28010116

Cited by 8 publications

(4 citation statements)

References 195 publications

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“…Additionally, research has identified exosomes as an important medium of information exchange through cytoplasmic division, membrane fusion, and receptor-mediated transport, which in turn affect the metabolism and function of recipient cells. 79,80 This action of exosomes links each individual cell together to form a system that synergistically regulates a number of biogenesis…”

Section: Exosome Biogenesis and Applicationsmentioning

confidence: 99%

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Hu,

Yang,

Wang

et al. 2024

IJN

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Adoptive T cells immunotherapy, specifically chimeric antigen receptor T cells (CAR-T), has shown promising therapeutic efficacy in the treatment of hematologic malignancies. As extensive research on CAR-T therapies has been conducted, various challenges have emerged that significantly hampered their clinical application, including tumor recurrence, CAR-T cell exhaustion, and cytokine release syndrome (CRS). To overcome the hurdles of CAR-T therapy in clinical treatment, cell-free emerging therapies based on exosomes derived from CAR-T cells have been developed as an effective and promising alternative approach. In this review, we present CAR-T cell-based therapies for the treatment of tumors, including the features and benefits of CAR-T therapies, the limitations that exist in this field, and the measures taken to overcome them. Furthermore, we discuss the notable benefits of utilizing exosomes released from CAR-T cells in tumor treatment and anticipate potential issues in clinical trials. Lastly, drawing from previous research on exosomes from CAR-T cells and the characteristics of exosomes, we propose strategies to overcome these restrictions. Additionally, the review discusses the plight in large-scale preparation of exosome and provides potential solutions for future clinical applications.

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Section: Exosome Biogenesis and Applicationsmentioning

confidence: 99%

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Hu,

Yang,

Wang

et al. 2024

IJN

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“…Drug resistance is the main challenge in management in a broad range of cancers, especially in MM. In the process of myelomagenesis, the bone marrow microenvironment provides an intricate network of cellular communication to favor the tumor niche formation [ 147 ]. Targeting this intracellular network provides new opportunities for the therapy of the disease.…”

Section: Potential Therapeutic Strategies Targeting the Exosomes In MMmentioning

confidence: 99%

“…Targeting this intracellular network provides new opportunities for the therapy of the disease. Regarding the importance of exosomal miRNAs in the communications within the BME in developing drug resistance and the progress of the disease, they are considered as desirable therapeutic targets in MM treatment interventions [ 147 ]. Exosome-based strategies in cancer therapy or diagnosis have currently achieved a high level of interest, crucially focusing upon (1) inhibiting exosome-mediated crosstalks by reducing the production of exosomes and/or blocking their uptake, (2) their usage as therapeutic tools for the delivery of drugs, and (3) their role as potential biomarkers for early diagnosis, prognosis, or response to therapy.…”

Section: Potential Therapeutic Strategies Targeting the Exosomes In MMmentioning

confidence: 99%

Exosomal miRNAs in the Tumor Microenvironment of Multiple Myeloma

Alipoor

Chang

2023

Cells

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Multiple myeloma (MM) is a malignancy of plasma cells in the bone marrow and is characterized by the clonal proliferation of B-cells producing defective monoclonal immunoglobulins. Despite the latest developments in treatment, drug resistance remains one of the major challenges in the therapy of MM. The crosstalk between MM cells and other components within the bone marrow microenvironment (BME) is the major determinant of disease phenotypes. Exosomes have emerged as the critical drivers of this crosstalk by allowing the delivery of informational cargo comprising multiple components from miniature peptides to nucleic acids. Such material transfers have now been shown to perpetuate drug-resistance development and disease progression in MM. MicroRNAs(miRNAs) specifically play a crucial role in this communication considering their small size that allows them to be readily packed within the exosomes and widespread potency that impacts the developmental trajectory of the disease inside the tumor microenvironment (TME). In this review, we aim to provide an overview of the current understanding of the role of exosomal miRNAs in the epigenetic modifications inside the TME and its pathogenic influence on the developmental phenotypes and prognosis of MM.

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“…By inhibiting or promoting the transcription and translation of target genes, exosomal miRNAs can affect cell biological functions and play a crucial role in intercellular signaling, cell growth and differentiation, being considered a unique type of regulatory molecules ( Garcia-Martin et al, 2022 ). In the past decade, molecular research has shown that exosomal miRNAs impact the development and progression of an array of diseases, such as metabolic diseases ( Castaño et al, 2018 ; Xu et al, 2022b ), tumors ( Cariello et al, 2022 ), hepatitis ( Qiu et al, 2022 ), renal system diseases ( Zhao et al, 2021a ), cardiovascular diseases ( Du et al, 2021 ), among others, significantly contributing to potential clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage

Liao,

Wang,

Wei

et al. 2023

Front. Mol. Neurosci.

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Subarachnoid hemorrhage (SAH) is a severe acute neurological disorder with a high fatality rate. Early brain injury (EBI) and cerebral vasospasm are two critical complications of SAH that significantly contribute to poor prognosis. Currently, surgical intervention and interventional therapy are the main treatment options for SAH, but their effectiveness is limited. Exosomes, which are a type of extracellular vesicles, play a crucial role in intercellular communication and have been extensively studied in the past decade due to their potential influence on disease progression, diagnosis, and treatment. As one of the most important components of exosomes, miRNA plays both direct and indirect roles in affecting disease progression. Previous research has found that exosomal miRNA is involved in the development of various diseases, such as tumors, chronic hepatitis, atherosclerosis, diabetes, and SAH. This review focuses on exploring the impact of exosomal miRNA on SAH, including its influence on neuronal apoptosis, inflammatory response, and immune activation following SAH. Furthermore, this review highlights the potential clinical applications of exosomal miRNA in the treatment of SAH. Although current research on this topic is limited and the clinical application of exosomal miRNA has inherent limitations, we aim to provide a concise summary of existing research progress and offer new insights for future research directions and trends in this field.

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Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Cited by 8 publications

References 195 publications

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Emerging Strategies to Overcome Current CAR-T Therapy Dilemmas - Exosomes Derived from CAR-T Cells

Exosomal miRNAs in the Tumor Microenvironment of Multiple Myeloma

Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage

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